Chapter 10: Antimicrobial Drugs

First mass produced in the 1940s, penicillin was instrumental in saving millions of lives during World War II and was considered a wonder drug. Today, overprescription of antibiotics (especially for childhood illnesses) has contributed to the evolution of drug-resistant pathogens.
Figure 10.1 First mass produced in the 1940s, penicillin was instrumental in saving millions of lives during World War II and was considered a wonder drug.[footnote]“Treatment of War Wounds: A Historical Review.” Clinical Orthopaedics and Related Research 467 no. 8 (2009):2168–2191.[/footnote] Today, overprescription of antibiotics (especially for childhood illnesses) has contributed to the evolution of drug-resistant pathogens. (credit left: modification of work by Chemical Heritage Foundation; credit right: modification of work by U.S. Department of Defense)

Chapter Outline

10.1 Fundamentals of Antimicrobial Chemotherapy

10.2 Mechanisms of Antibacterial Drugs

10.3 Mechanisms of Other Antimicrobial Drugs

14.4 Drug Resistance

10.5 Testing the Effectiveness of Antimicrobials

10.6 Current Strategies for Antimicrobial Discovery

Introduction

In nature, some microbes produce substances that inhibit or kill other microbes that might otherwise compete for the same resources. Humans have successfully exploited these abilities, using microbes to mass-produce substances that can be used as antimicrobial drugs (see Figure 10.1). Since their discovery, antimicrobial drugs have saved countless lives, and they remain an essential tool for treating and controlling infectious disease. But their widespread and often unnecessary use has had an unintended side effect: the rise of multidrug-resistant microbial strains. In this chapter, we will discuss how antimicrobial drugs work, why microbes develop resistance, and what health professionals can do to encourage responsible use of antimicrobials.

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