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Glossary

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A

α-dextrin
breakdown product of starch
α-dextrinase
brush border enzyme that acts on α-dextrins
abdominal aorta
portion of the aorta inferior to the aortic hiatus and superior to the common iliac arteries
abdominopelvic cavity
division of the anterior (ventral) cavity that houses the abdominal and pelvic viscera
abducens nerve
sixth cranial nerve; responsible for contraction of one of the extraocular muscles
abduct
move away from midline in the sagittal plane
abduction
movement in the coronal plane that moves a limb laterally away from the body; spreading of the fingers
abductor
moves the bone away from the midline
abductor digiti minimi
muscle that abducts the little finger
abductor pollicis brevis
muscle that abducts the thumb
abductor pollicis longus
muscle that inserts into the first metacarpal
ABO blood group
blood-type classification based on the presence or absence of A and B glycoproteins on the erythrocyte membrane surface
absolute refractory period
time during an action period when another action potential cannot be generated because the voltage-gated Na+ channel is inactivated
absorption
passage of digested products from the intestinal lumen through mucosal cells and into the bloodstream or lacteals
absorptive state
also called the fed state; the metabolic state occurring during the first few hours after ingesting food in which the body is digesting food and absorbing the nutrients
accessory digestive organ
includes teeth, tongue, salivary glands, gallbladder, liver, and pancreas
accessory duct
(also, duct of Santorini) duct that runs from the pancreas into the duodenum
acclimatization
process of adjustment that the respiratory system makes due to chronic exposure to high altitudes
accommodation
in vision, a change in the ability of the eye to focus on objects at different distances
accommodation–convergence reflex
coordination of somatic control of the medial rectus muscles of either eye with the parasympathetic control of the ciliary bodies to maintain focus while the eyes converge on visual stimuli near to the face
acetabular labrum
lip of fibrocartilage that surrounds outer margin of the acetabulum on the hip bone
acetabulum
large, cup-shaped cavity located on the lateral side of the hip bone; formed by the junction of the ilium, pubis, and ischium portions of the hip bone
acetyl coenzyme A (acetyl CoA)
starting molecule of the Krebs cycle
acetylcholine (ACh)
neurotransmitter that binds at a motor end-plate to trigger depolarization
acid
compound that releases hydrogen ions (H+) in solution
acinus
cluster of glandular epithelial cells in the pancreas that secretes pancreatic juice in the pancreas
acne
skin condition due to infected sebaceous glands
acromegaly
disorder in adults caused when abnormally high levels of GH trigger growth of bones in the face, hands, and feet
acromial end of the clavicle
lateral end of the clavicle that articulates with the acromion of the scapula
acromial process
acromion of the scapula
acromioclavicular joint
articulation between the acromion of the scapula and the acromial end of the clavicle
acromion
flattened bony process that extends laterally from the scapular spine to form the bony tip of the shoulder
acrosomal reaction
release of digestive enzymes by sperm that enables them to burrow through the corona radiata and penetrate the zona pellucida of an oocyte prior to fertilization
acrosome
cap-like vesicle located at the anterior-most region of a sperm that is rich with lysosomal enzymes capable of digesting the protective layers surrounding the oocyte
actin
protein that makes up most of the thin myofilaments in a sarcomere muscle fiber
action potential
change in voltage of a cell membrane in response to a stimulus that results in transmission of an electrical signal; unique to neurons and muscle fibers
activation energy
amount of energy greater than the energy contained in the reactants, which must be overcome for a reaction to proceed
activation gate
part of the voltage-gated Na+ channel that opens when the membrane voltage reaches threshold
active immunity
immunity developed from an individual’s own immune system
acute inflammation
inflammation occurring for a limited time period; rapidly developing
acute mountain sickness (AMS)
condition that occurs a result of acute exposure to high altitude due to a low partial pressure of oxygen
adaptive immune response
relatively slow but very specific and effective immune response controlled by lymphocytes
adduction
movement in the coronal plane that moves a limb medially toward or across the midline of the body; bringing fingers together
adductor
moves the bone toward the midline
adductor brevis
muscle that adducts and medially rotates the thigh
adductor longus
muscle that adducts, medially rotates, and flexes the thigh
adductor magnus
muscle with an anterior fascicle that adducts, medially rotates and flexes the thigh, and a posterior fascicle that assists in thigh extension
adductor pollicis
muscle that adducts the thumb
adductor tubercle
small, bony bump located on the superior aspect of the medial epicondyle of the femur
adenosine triphosphate (ATP)
nucleotide containing ribose and an adenine base that is essential in energy transfer
adenylyl cyclase
membrane-bound enzyme that converts ATP to cyclic AMP, creating cAMP, as a result of G-protein activation
adipocytes
lipid storage cells
adipose tissue
specialized areolar tissue rich in stored fat
adrenal artery
branch of the abdominal aorta; supplies blood to the adrenal (suprarenal) glands
adrenal cortex
outer region of the adrenal glands consisting of multiple layers of epithelial cells and capillary networks that produces mineralocorticoids and glucocorticoids
adrenal glands
endocrine glands located at the top of each kidney that are important for the regulation of the stress response, blood pressure and blood volume, water homeostasis, and electrolyte levels
adrenal medulla
interior portion of the adrenal gland that releases hormonal epinephrine and norepinephrine into the bloodstream in the stress response
adrenal vein
drains the adrenal or suprarenal glands that are immediately superior to the kidneys; the right adrenal vein enters the inferior vena cava directly and the left adrenal vein enters the left renal vein
adrenergic
synapse where norepinephrine is released, which binds to α- or β-adrenergic receptors
adrenocorticotropic hormone (ACTH)
anterior pituitary hormone that stimulates the adrenal cortex to secrete corticosteroid hormones (also called corticotropin)
aerobic respiration
production of ATP in the presence of oxygen
afferent branch
component of a reflex arc that represents the input from a sensory neuron, for either a special or general sense
afferent lymphatic vessels
lead into a lymph node
afterbirth
third stage of childbirth in which the placenta and associated fetal membranes are expelled
afterload
force the ventricles must develop to effectively pump blood against the resistance in the vessels
agglutination
clustering of cells into masses linked by antibodies
agonist (muscles)
(also, prime mover) muscle whose contraction is responsible for producing a particular motion
agonist (substance)
any exogenous substance that binds to a receptor and produces a similar effect to the endogenous ligand
agranular leukocytes
leukocytes with few granules in their cytoplasm; specifically, monocytes, lymphocytes, and NK cells
ala
(plural = alae) small, flaring structure of a nostril that forms the lateral side of the nares
alar cartilage
cartilage that supports the apex of the nose and helps shape the nares; it is connected to the septal cartilage and connective tissue of the alae
alar plate
developmental region of the spinal cord that gives rise to the posterior horn of the gray matter
alarm reaction
the short-term stress, or the fight-or-flight response, of stage one of the general adaptation syndrome mediated by the hormones epinephrine and norepinephrine
albinism
genetic disorder that affects the skin, in which there is no melanin production
albumin
most abundant plasma protein, accounting for most of the osmotic pressure of plasma
aldosterone
hormone produced and secreted by the adrenal cortex that stimulates sodium and fluid retention and increases blood volume and blood pressure
alimentary canal
continuous muscular digestive tube that extends from the mouth to the anus
alkaloid
substance, usually from a plant source, that is chemically basic with respect to pH and will stimulate bitter receptors
allantois
finger-like outpocketing of yolk sac forms the primitive excretory duct of the embryo; precursor to the urinary bladder
allele
alternative forms of a gene that occupy a specific locus on a specific gene
alpha (α)-adrenergic receptor
one of the receptors to which epinephrine and norepinephrine bind, which comes in three subtypes: α1, α2, and α3
alpha cell
pancreatic islet cell type that produces the hormone glucagon
alveolar dead space
air space within alveoli that are unable to participate in gas exchange
alveolar duct
small tube that leads from the terminal bronchiole to the respiratory bronchiole and is the point of attachment for alveoli
alveolar macrophage
immune system cell of the alveolus that removes debris and pathogens
alveolar pore
opening that allows airflow between neighboring alveoli
alveolar process of the mandible
upper border of mandibular body that contains the lower teeth
alveolar process of the maxilla
curved, inferior margin of the maxilla that supports and anchors the upper teeth
alveolar sac
cluster of alveoli
alveoli
(of the breast) milk-secreting cells in the mammary gland
alveolus
small, grape-like sac that performs gas exchange in the lungs
amacrine cell
type of cell in the retina that connects to the bipolar cells near the outer synaptic layer and provides the basis for early image processing within the retina
amino acid
building block of proteins; characterized by an amino and carboxyl functional groups and a variable side-chain
aminopeptidase
brush border enzyme that acts on proteins
amnion
transparent membranous sac that encloses the developing fetus and fills with amniotic fluid
amniotic cavity
cavity that opens up between the inner cell mass and the trophoblast; develops into amnion
amphiarthrosis
slightly mobile joint
amphipathic
describes a molecule that exhibits a difference in polarity between its two ends, resulting in a difference in water solubility
ampulla of the ear
the structure at the base of a semicircular canal that contains the hair cells and cupula for transduction of rotational movement of the head
ampulla of the uterine
middle portion of the uterine tube in which fertilization often occurs
amygdala
nucleus deep in the temporal lobe of the cerebrum that is related to memory and emotional behavior
anabolic hormones
hormones that stimulate the synthesis of new, larger molecules
anabolic reactions
reactions that build smaller molecules into larger molecules
anagen
active phase of the hair growth cycle
anal canal
final segment of the large intestine
anal column
long fold of mucosa in the anal canal
anal sinus
recess between anal columns
anal triangle
posterior triangle of the perineum that includes the anus
anaphase
third stage of mitosis (and meiosis), during which sister chromatids separate into two new nuclear regions of a dividing cell
anaphylactic shock
type of shock that follows a severe allergic reaction and results from massive vasodilation
anastomosis
(plural = anastomoses) area where vessels unite to form interconnections that normally allow blood to circulate to a region even if there is a partial blockage in one contributing branch
anatomical dead space
air space present in the airway that never reaches the alveoli and therefore never participates in gas exchange
anatomical neck
line on the humerus located around the outside margin of the humeral head
anatomical position
standard reference position used for describing locations and directions on the human body
anatomical sphincter
smooth or skeletal muscle surrounding the lumen of a vessel or hollow organ that can restrict flow when contracted
anatomy
science that studies the form and composition of the body’s structures
anchoring junction
mechanically attaches adjacent cells to each other or to the basement membrane
anconeus
small muscle on the lateral posterior elbow that extends the forearm
anemia
deficiency of red blood cells or hemoglobin
angioblasts
stem cells that give rise to blood vessels
angiogenesis
development of new blood vessels from existing vessels
angiotensin-converting enzyme
the enzyme that converts angiotensin I to angiotensin II
angle of the mandible
rounded corner located at outside margin of the body and ramus junction
angle of the rib
portion of rib with greatest curvature; together, the rib angles form the most posterior extent of the thoracic cage
anion
atom with a negative charge
ankle joint
joint that separates the leg and foot portions of the lower limb; formed by the articulations between the talus bone of the foot inferiorly, and the distal end of the tibia, medial malleolus of the tibia, and lateral malleolus of the fibula superiorly
annular ligament
intrinsic ligament of the elbow articular capsule that surrounds and supports the head of the radius at the proximal radioulnar joint
antagonist (muscles)
muscle that opposes the action of an agonist
antagonist (substance)
any exogenous substance that binds to a receptor and produces an opposing effect to the endogenous ligand
anterior
describes the front or direction toward the front of the body; also referred to as ventral
anterior (ventral) sacral foramen
one of the series of paired openings located on the anterior (ventral) side of the sacrum
anterior arch
anterior portion of the ring-like C1 (atlas) vertebra
anterior border of the tibia
narrow, anterior margin of the tibia that extends inferiorly from the tibial tuberosity
anterior cardiac veins
vessels that parallel the small cardiac arteries and drain the anterior surface of the right ventricle; bypass the coronary sinus and drain directly into the right atrium
anterior cerebral artery
arises from the internal carotid artery; supplies the frontal lobe of the cerebrum
anterior column
white matter between the anterior horns of the spinal cord composed of many different groups of axons of both ascending and descending tracts
anterior communicating artery
anastomosis of the right and left internal carotid arteries; supplies blood to the brain
anterior compartment of the arm
(anterior flexor compartment of the arm) the biceps brachii, brachialis, brachioradialis, and their associated blood vessels and nerves
anterior compartment of the forearm
(anterior flexor compartment of the forearm) deep and superficial muscles that originate on the humerus and insert into the hand
anterior compartment of the leg
region that includes muscles that dorsiflex the foot
anterior compartment of the thigh
region that includes muscles that flex the thigh and extend the leg
anterior corticospinal tract
division of the corticospinal pathway that travels through the ventral (anterior) column of the spinal cord and controls axial musculature through the medial motor neurons in the ventral (anterior) horn
anterior cranial fossa
shallowest and most anterior cranial fossa of the cranial base that extends from the frontal bone to the lesser wing of the sphenoid bone
anterior cruciate ligament
intracapsular ligament of the knee; extends from anterior, superior surface of the tibia to the inner aspect of the lateral condyle of the femur; resists hyperextension of knee
anterior horn
gray matter of the spinal cord containing multipolar motor neurons, sometimes referred to as the ventral horn
anterior inferior iliac spine
small, bony projection located on the anterior margin of the ilium, below the anterior superior iliac spine
anterior interventricular artery
(also, left anterior descending artery or LAD) major branch of the left coronary artery that follows the anterior interventricular sulcus
anterior interventricular sulcus
sulcus located between the left and right ventricles on the anterior surface of the heart
anterior longitudinal ligament
ligament that runs the length of the vertebral column, uniting the anterior aspects of the vertebral bodies
anterior median fissure
deep midline feature of the anterior spinal cord, marking the separation between the right and left sides of the cord
anterior sacroiliac ligament
strong ligament between the sacrum and the ilium portions of the hip bone that supports the anterior side of the sacroiliac joint
anterior scalene
a muscle anterior to the middle scalene
anterior spinal artery
blood vessel from the merged branches of the vertebral arteries that runs along the anterior surface of the spinal cord
anterior superior iliac spine
rounded, anterior end of the iliac crest
anterior talofibular ligament
intrinsic ligament located on the lateral side of the ankle joint, between talus bone and lateral malleolus of fibula; supports talus at the talocrural joint and resists excess inversion of the foot
anterior tibial artery
branches from the popliteal artery; supplies blood to the anterior tibial region; becomes the dorsalis pedis artery
anterior tibial vein
forms from the dorsal venous arch; drains the area near the tibialis anterior muscle and leads to the popliteal vein
anterograde amnesia
inability to form new memories from a particular time forward
antibodies
(also, immunoglobulins or gamma globulins) antigen-specific proteins produced by specialized B lymphocytes that protect the body by binding to foreign objects such as bacteria and viruses
antibody
antigen-specific protein secreted by plasma cells; immunoglobulin
anticholinergic drugs
drugs that interrupt or reduce the function of the parasympathetic system
anticoagulant
substance such as heparin that opposes coagulation
anticodon
consecutive sequence of three nucleotides on a tRNA molecule that is complementary to a specific codon on an mRNA molecule
antidiuretic hormone (ADH)
(also, vasopressin) hypothalamic hormone stored by the posterior pituitary that signals the kidneys to increase the volume of water reabsorbed from the collecting tubules
antigen
molecule recognized by the receptors of B and T lymphocytes
antigen presentation
binding of processed antigen to the protein-binding cleft of a major histocompatibility complex molecule
antigen processing
internalization and digestion of antigen in an antigen-presenting cell
antigen receptor
two-chain receptor by which lymphocytes recognize antigen
antigenic determinant
(also, epitope) one of the chemical groups recognized by a single type of lymphocyte antigen receptor
antithrombin
anticoagulant that inactivates factor X and opposes the conversion of prothrombin (factor II) into thrombin in the common pathway
antrum
fluid-filled chamber that characterizes a mature tertiary (antral) follicle
anulus fibrosus
tough, fibrous outer portion of an intervertebral disc, which is strongly anchored to the bodies of the adjacent vertebrae
aorta
largest artery in the body, originating from the left ventricle and descending to the abdominal region where it bifurcates into the common iliac arteries at the level of the fourth lumbar vertebra; arteries originating from the aorta distribute blood to virtually all tissues of the body
aortic arch
arc that connects the ascending aorta to the descending aorta; ends at the intervertebral disk between the fourth and fifth thoracic vertebrae
aortic hiatus
opening in the diaphragm that allows passage of the thoracic aorta into the abdominal region where it becomes the abdominal aorta
aortic sinuses
small pockets in the ascending aorta near the aortic valve that are the locations of the baroreceptors (stretch receptors) and chemoreceptors that trigger a reflex that aids in the regulation of vascular homeostasis
aortic valve
(also, aortic semilunar valve) valve located at the base of the aorta
apex
tip of the external nose
aphasia
loss of language function
apical
that part of a cell or tissue which, in general, faces an open space
apical ectodermal ridge
enlarged ridge of ectoderm at the distal end of a limb bud that stimulates growth and elongation of the limb
apneustic center
network of neurons within the pons that stimulate the neurons in the dorsal respiratory group; controls the depth of inspiration
apocrine secretion
release of a substance along with the apical portion of the cell
apocrine sweat gland
type of sweat gland that is associated with hair follicles in the armpits and genital regions
aponeurosis
broad, tendon-like sheet of connective tissue that attaches a skeletal muscle to another skeletal muscle or to a bone
apoptosis
programmed cell death
appendicular
of the arms and legs
appendicular skeleton
all bones of the upper and lower limbs, plus the girdle bones that attach each limb to the axial skeleton
appendix
(vermiform appendix) coiled tube attached to the cecum
appositional growth
growth by adding to the free surface of bone, can occur at endosteum or periosteum
aqueous humor
watery fluid that fills the anterior chamber containing the cornea, iris, ciliary body, and lens of the eye
arachnoid granulation
outpocket of the arachnoid membrane into the dural sinuses that allows for reabsorption of CSF into the blood
arachnoid mater
middle layer of the meninges named for the spider-web–like trabeculae that extend between it and the pia mater
arachnoid trabeculae
filaments between the arachnoid and pia mater within the subarachnoid space
arcuate line of the ilium
smooth ridge located at the inferior margin of the iliac fossa; forms the lateral portion of the pelvic brim
areola
highly pigmented, circular area surrounding the raised nipple and containing areolar glands that secrete fluid important for lubrication during suckling
areolar tissue
(also, loose connective tissue) a type of connective tissue proper that shows little specialization with cells dispersed in the matrix
arm
region of the upper limb located between the shoulder and elbow joints; contains the humerus bone
arrector pili
smooth muscle that is activated in response to external stimuli that pull on hair follicles and make the hair “stand up”
arrhythmia
an abnormal heart rhythm
arterial circle
(also, circle of Willis) anastomosis located at the base of the brain that ensures continual blood supply; formed from branches of the internal carotid and vertebral arteries; supplies blood to the brain
arteriole
(also, resistance vessel) very small artery that leads to a capillary
arteriovenous anastomosis
short vessel connecting an arteriole directly to a venule and bypassing the capillary beds
artery
blood vessel that conducts blood away from the heart; may be a conducting or distributing vessel
articular capsule
connective tissue structure that encloses the joint cavity of a synovial joint
articular cartilage
thin layer of hyaline cartilage that covers articulating surfaces of bones at a synovial joint; reduces friction and acts as a shock absorber
articular disc
meniscus; a fibrocartilage structure found between the bones of some synovial joints; provides padding or smooths movements between the bones; strongly unites the bones together
articular tubercle
smooth ridge located on the inferior skull, immediately anterior to the mandibular fossa
articulation
joint of the body (where two bone surfaces meet)
artificial pacemaker
medical device that transmits electrical signals to the heart to ensure that it contracts and pumps blood to the body
ascending aorta
initial portion of the aorta, rising from the left ventricle for a distance of approximately 5 cm
ascending colon
first region of the colon
ascending pathway
fiber structure that relays sensory information from the periphery through the spinal cord and brain stem to other structures of the brain
ascending tract
central nervous system fibers carrying sensory information from the spinal cord or periphery to the brain
association area
region of cortex connected to a primary sensory cortical area that further processes the information to generate more complex sensory perceptions
astrocyte
glial cell type of the CNS that provides support for neurons and maintains the blood-brain barrier
ataxia
movement disorder related to damage of the cerebellum characterized by loss of coordination in voluntary movements
atlanto-occipital joint
articulation between the occipital condyles of the skull and the superior articular processes of the atlas (C1 vertebra)
atlantoaxial joint
series of three articulations between the atlas (C1) vertebra and the axis (C2) vertebra, consisting of the joints between the inferior articular processes of C1 and the superior articular processes of C2, and the articulation between the dens of C2 and the anterior arch of C1
atlas
first cervical (C1) vertebra
atmospheric pressure
amount of force that is exerted by gases in the air surrounding any given surface
atom
smallest unit of an element that retains the unique properties of that element
atomic number
number of protons in the nucleus of an atom
ATP synthase
protein pore complex that creates ATP
ATPase
enzyme that hydrolyzes ATP to ADP
atrial natriuretic peptide (ANP)
peptide hormone produced by the walls of the atria in response to high blood pressure, blood volume, or blood sodium that reduces the reabsorption of sodium and water in the kidneys and promotes vasodilation
atrial reflex
mechanism for maintaining vascular homeostasis involving atrial baroreceptors: if blood is returning to the right atrium more rapidly than it is being ejected from the left ventricle, the atrial receptors will stimulate the cardiovascular centers to increase sympathetic firing and increase cardiac output until the situation is reversed; the opposite is also true
atrial reflex or Bainbridge reflex
autonomic reflex that responds to stretch receptors in the atria that send impulses to the cardioaccelerator area to increase HR when venous flow into the atria increases
atrioventricular (AV) node
clump of myocardial cells located in the inferior portion of the right atrium within the atrioventricular septum; receives the impulse from the SA node, pauses, and then transmits it into specialized conducting cells within the interventricular septum
atrioventricular bundle branches
(also, left or right bundle branches) specialized myocardial conductile cells that arise from the bifurcation of the atrioventricular bundle and pass through the interventricular septum; lead to the Purkinje fibers and also to the right papillary muscle via the moderator band
atrioventricular septum
cardiac septum located between the atria and ventricles; atrioventricular valves are located here
atrioventricular valves
one-way valves located between the atria and ventricles; the valve on the right is called the tricuspid valve, and the one on the left is the mitral or bicuspid valve
atrium
(plural = atria) upper or receiving chamber of the heart that pumps blood into the lower chambers just prior to their contraction; the right atrium receives blood from the systemic circuit that flows into the right ventricle; the left atrium receives blood from the pulmonary circuit that flows into the left ventricle
atrophy
loss of mass and function; in muscles, the loss of structural proteins from muscle fibers
audition
sense of hearing
auricle of the ear
fleshy external structure of the ear
auricle of the heart
extension of an atrium visible on the superior surface of the heart
auricular surface of the ilium
roughened area located on the posterior, medial side of the ilium of the hip bone; articulates with the auricular surface of the sacrum to form the sacroiliac joint
autocrine
chemical signal that elicits a response in the same cell that secreted it
autolysis
breakdown of cells by their own enzymatic action
autonomic nervous system (ANS)
functional division of the nervous system that is responsible for homeostatic reflexes that coordinate control of cardiac and smooth muscle, as well as glandular tissue
autonomic tone
continuous baseline activity of each division of the ANS which governs organ system activity at a given time
autophagy
lysosomal breakdown of a cell’s own components
autorhythmicity
ability of cardiac muscle to initiate its own electrical impulse that triggers the mechanical contraction that pumps blood at a fixed pace without nervous or endocrine control
autosomal chromosome
in humans, the 22 pairs of chromosomes that are not the sex chromosomes (XX or XY)
autosomal dominant
pattern of dominant inheritance that corresponds to a gene on one of the 22 autosomal chromosomes
autosomal recessive
pattern of recessive inheritance that corresponds to a gene on one of the 22 autosomal chromosomes
axial
of the trunk and head
axial skeleton
central, vertical axis of the body, including the skull, vertebral column, and thoracic cage
axillary artery
continuation of the subclavian artery as it penetrates the body wall and enters the axillary region; supplies blood to the region near the head of the humerus (humeral circumflex arteries); the majority of the vessel continues into the brachium and becomes the brachial artery
axillary nerve
systemic nerve of the arm that arises from the brachial plexus
axillary vein
major vein in the axillary region; drains the upper limb and becomes the subclavian vein
axis
second cervical (C2) vertebra
axon
single process of the neuron that carries an electrical signal (action potential) away from the cell body toward a target cell
axon hillock
region of the neuron cell body that gives rise to the axon
axon terminal (terminal end)
end of the axon, where there are usually several branches extending toward the target cell
azygos vein
originates in the lumbar region and passes through the diaphragm into the thoracic cavity on the right side of the vertebral column; drains blood from the intercostal veins, esophageal veins, bronchial veins, and other veins draining the mediastinal region; leads to the superior vena cava

B

B cells
lymphocytes that act by differentiating into an antibody-secreting plasma cell
B lymphocytes
(also, B cells) lymphocytes that defend the body against specific pathogens and thereby provide specific immunity
Babinski sign
dorsiflexion of the foot with extension and splaying of the toes in response to the plantar reflex, normally suppressed by corticospinal input
Bachmann’s bundle
(also, interatrial band) group of specialized conducting cells that transmit the impulse directly from the SA node in the right atrium to the left atrium
bacterial flora
bacteria in the large intestine
ball-and-socket joint
synovial joint formed between the spherical end of one bone (the ball) that fits into the depression of a second bone (the socket); found at the hip and shoulder joints; functionally classified as a multiaxial joint
baroreceptor
mechanoreceptor that senses the stretch of blood vessels to indicate changes in blood pressure
baroreceptor reflex
autonomic reflex in which the cardiac centers monitor signals from the baroreceptor stretch receptors and regulate heart function based on blood flow
barrier defenses
antipathogen defenses deriving from a barrier that physically prevents pathogens from entering the body to establish an infection
Bartholin’s glands
(also, greater vestibular glands) glands that produce a thick mucus that maintains moisture in the vulva area; also referred to as the greater vestibular glands
basal cell
type of stem cell found in the stratum basale and in the hair matrix that continually undergoes cell division, producing the keratinocytes of the epidermis
basal cell carcinoma
cancer that originates from basal cells in the epidermis of the skin
basal forebrain
nuclei of the cerebrum related to modulation of sensory stimuli and attention through broad projections to the cerebral cortex, loss of which is related to Alzheimer’s disease
basal lamina
thin extracellular layer that lies underneath epithelial cells and separates them from other tissues
basal metabolic rate (BMR)
amount of energy expended by the body at rest
basal nuclei
nuclei of the cerebrum (with a few components in the upper brain stem and diencephalon) that are responsible for assessing cortical movement commands and comparing them with the general state of the individual through broad modulatory activity of dopamine neurons; largely related to motor functions, as evidenced through the symptoms of Parkinson’s and Huntington’s diseases
basal plate
developmental region of the spinal cord that gives rise to the lateral and anterior horns of gray matter
base
compound that accepts hydrogen ions (H+) in solution
base of the metatarsal bone
expanded, proximal end of each metatarsal bone
basement membrane
in epithelial tissue, a thin layer of fibrous material that anchors the epithelial tissue to the underlying connective tissue; made up of the basal lamina and reticular lamina
basilar artery
blood vessel formed from the fusion of the two vertebral arteries which runs along the dorsal surface of the brain stem; sends branches to the cerebellum, brain stem, and the posterior cerebral arteries
basilar membrane
in the ear, the floor of the cochlear duct on which the organ of Corti sits
basilic vein
superficial vein of the arm that arises from the palmar venous arches, intersects with the median cubital vein, parallels the ulnar vein, and continues into the upper arm; along with the brachial vein, it leads to the axillary vein
basophils
granulocytes that stain with a basic (alkaline) stain and store histamine and heparin
bedsore
sore on the skin that develops when regions of the body start necrotizing due to constant pressure and lack of blood supply; also called decubitis ulcers
belly
bulky central body of a muscle
beta (β)-adrenergic receptor
one of the receptors to which epinephrine and norepinephrine bind, which comes in two subtypes: β1 and β2
beta (β)-hydroxybutyrate
primary ketone body produced in the body
beta (β)-oxidation
fatty acid oxidation
beta cell
pancreatic islet cell type that produces the hormone insulin
Betz cells
output cells of the primary motor cortex that cause musculature to move through synapses on cranial and spinal motor neurons
bi
two
biaxial joint
type of diarthrosis; a joint that allows for movements within two planes (two axes)
biceps brachii
two-headed muscle that crosses the shoulder and elbow joints to flex the forearm while assisting in supinating it and flexing the arm at the shoulder
biceps femoris
hamstring muscle
bicipital groove
intertubercular groove; narrow groove located between the greater and lesser tubercles of the humerus
bicuspid valve
(also, mitral valve or left atrioventricular valve) valve located between the left atrium and ventricle; consists of two flaps of tissue
bile
alkaline solution produced by the liver and important for the emulsification of lipids
bile canaliculus
small duct between hepatocytes that collects bile
bile salts
salts that are released from the liver in response to lipid ingestion and surround the insoluble triglycerides to aid in their conversion to monoglycerides and free fatty acids
bilirubin
main bile pigment which is produced when iron is removed from heme and is further broken down into waste products, responsible for the brown color of feces
biliverdin
green bile pigment produced when the non-iron portion of heme is degraded into a waste product; converted to bilirubin in the liver
binocular depth cues
indications of the distance of visual stimuli on the basis of slight differences in the images projected onto either retina
biogenic amine
class of neurotransmitters that are enzymatically derived from amino acids but no longer contain a carboxyl group
biosynthesis reactions
reactions that create new molecules, also called anabolic reactions
bipennate
pennate muscle that has fascicles that are located on both sides of the tendon
bipolar cell
cell type in the retina that connects the photoreceptors to the RGCs
bipolar neuron
shape of a neuron with two processes extending from the neuron cell body—the axon and one dendrite
blastocoel
fluid-filled cavity of the blastocyst
blastocyst
term for the conceptus at the developmental stage that consists of about 100 cells shaped into an inner cell mass that is fated to become the embryo and an outer trophoblast that is fated to become the associated fetal membranes and placenta
blastomere
daughter cell of a cleavage
blood
liquid connective tissue composed of formed elements—erythrocytes, leukocytes, and platelets—and a fluid extracellular matrix called plasma; component of the cardiovascular system
blood colloid osmotic pressure (BCOP)
pressure exerted by colloids suspended in blood within a vessel; a primary determinant is the presence of plasma proteins
blood colloidal osmotic pressure (BCOP)
pressure exerted by colloids suspended in blood within a vessel; a primary determinant is the presence of plasma proteins
blood flow
movement of blood through a vessel, tissue, or organ that is usually expressed in terms of volume per unit of time
blood hydrostatic pressure
force blood exerts against the walls of a blood vessel or heart chamber
blood islands
masses of developing blood vessels and formed elements from mesodermal cells scattered throughout the embryonic disc
blood pressure
force exerted by the blood against the wall of a vessel or heart chamber; can be described with the more generic term hydrostatic pressure
blood vessel diameter
the distance between the opposite inside walls of a blood vessel, which increases with vasodilation and decreases with vasoconstriction
blood vessel length
the distance of a blood vessel or blood vessels from end to end; a longer blood vessel reduces blood flow more than a shorter vessel
blood viscosity
the thickness of a fluid, where a high viscosity fluid is thicker than a low viscosity fluid
blood-brain barrier (BBB)
physiological barrier between the circulatory system and the central nervous system that establishes a privileged blood supply, restricting the flow of substances into the CNS
blood–testis barrier
tight junctions between Sertoli cells that prevent bloodborne pathogens from gaining access to later stages of spermatogenesis and prevent the potential for an autoimmune reaction to haploid sperm
body
mid-portion of the stomach
body mass index (BMI)
relative amount of body weight compared to the overall height; a BMI ranging from 18–24.9 is considered normal weight, 25–29.9 is considered overweight, and greater than 30 is considered obese
body of the rib
shaft portion of a rib
body of uterus
middle section of the uterus
Bohr effect
relationship between blood pH and oxygen dissociation from hemoglobin
bolus
mass of chewed food
bond
electrical force linking atoms
bone (osseous) tissue
hard, dense connective tissue that forms the structural elements of the skeleton
bone marrow
tissue found inside bones; the site of all blood cell differentiation and maturation of B lymphocytes
bone marrow biopsy
diagnostic test of a sample of red bone marrow
bone marrow transplant
treatment in which a donor’s healthy bone marrow with its stem cells replaces diseased or damaged bone marrow of a patient
Bowman’s capsule
cup-shaped sack lined by a simple squamous epithelium (parietal surface) and specialized cells called podocytes (visceral surface) that participate in the filtration process; receives the filtrate which then passes on to the PCTs
Boyle’s law
relationship between volume and pressure as described by the formula: P1V1 = P2V2
brachial artery
continuation of the axillary artery in the brachium; supplies blood to much of the brachial region; gives off several smaller branches that provide blood to the posterior surface of the arm in the region of the elbow; bifurcates into the radial and ulnar arteries at the coronoid fossa
brachial plexus
nerve plexus associated with the lower cervical spinal nerves and first thoracic spinal nerve
brachial vein
deeper vein of the arm that forms from the radial and ulnar veins in the lower arm; leads to the axillary vein
brachialis
muscle deep to the biceps brachii that provides power in flexing the forearm.
brachiocephalic artery
single vessel located on the right side of the body; the first vessel branching from the aortic arch; gives rise to the right subclavian artery and the right common carotid artery; supplies blood to the head, neck, upper limb, and wall of the thoracic region
brachiocephalic vein
one of a pair of veins that form from a fusion of the external and internal jugular veins and the subclavian vein; subclavian, external and internal jugulars, vertebral, and internal thoracic veins lead to it; drains the upper thoracic region and flows into the superior vena cava
brachioradialis
muscle that can flex the forearm quickly or help lift a load slowly
brain
the large organ of the central nervous system contained within the cranium and continuous with the spinal cord
brain stem
region of the adult brain that includes the midbrain, pons, and medulla oblongata and develops from the mesencephalon, metencephalon, and myelencephalon of the embryonic brain
Braxton Hicks contractions
weak and irregular peristaltic contractions that can occur in the second and third trimesters; they do not indicate that childbirth is imminent
brevis
short
bridge
portion of the external nose that lies in the area of the nasal bones
broad ligament
wide ligament that supports the uterus by attaching laterally to both sides of the uterus and pelvic wall
Broca’s area
region of the frontal lobe associated with the motor commands necessary for speech production, located only in the cerebral hemisphere for language production
Brodmann’s areas
mapping of regions of the cerebral cortex based on microscopic anatomy that relates specific areas to functional differences, as described by Brodmann in the early 1900s
bronchial artery
systemic branch from the aorta that provides oxygenated blood to the lungs in addition to the pulmonary circuit
bronchial bud
structure in the developing embryo that forms when the laryngotracheal bud extends and branches to form two bulbous structures
bronchial tree
collective name for the multiple branches of the bronchi and bronchioles of the respiratory system
bronchial vein
drains the systemic circulation from the lungs and leads to the azygos vein
bronchiole
branch of bronchi that are 1 mm or less in diameter and terminate at alveolar sacs
bronchoconstriction
decrease in the size of the bronchiole due to contraction of the muscular wall
bronchodilation
increase in the size of the bronchiole due to contraction of the muscular wall
bronchus
tube connected to the trachea that branches into many subsidiaries and provides a passageway for air to enter and leave the lungs
Bronchus-associated lymphoid tissue (BALT)
lymphoid nodule associated with the respiratory tract
brown adipose tissue
highly vascularized fat tissue that is packed with mitochondria; these properties confer the ability to oxidize fatty acids to generate heat
brush border
fuzzy appearance certain cuboidal cells formed by microvilli which increase surface area for absorption; found in the small intestinal mucosa and proximal convoluted tubules of nephrons in the kidney
buccinator
muscle that compresses the cheek
buffer
solution containing a weak acid or a weak base that opposes wide fluctuations in the pH of body fluids
buffy coat
thin, pale layer of leukocytes and platelets that separates the erythrocytes from the plasma in a sample of centrifuged blood
bulbourethral glands
(also, Cowper’s glands) glands that secrete a lubricating mucus that cleans and lubricates the urethra prior to and during ejaculation
bulbus cordis
portion of the primitive heart tube that will eventually develop into the right ventricle
bundle of His
(also, atrioventricular bundle) group of specialized myocardial conductile cells that transmit the impulse from the AV node through the interventricular septum; form the left and right atrioventricular bundle branches
bursa
connective tissue sac containing lubricating fluid that prevents friction between adjacent structures, such as skin and bone, tendons and bone, or between muscles

C

calcaneal tendon
(also, Achilles tendon) strong tendon that inserts into the calcaneal bone of the ankle
calcaneofibular ligament
intrinsic ligament located on the lateral side of the ankle joint, between the calcaneus bone and lateral malleolus of the fibula; supports the talus bone at the ankle joint and resists excess inversion of the foot
calcaneus
heel bone; posterior, inferior tarsal bone that forms the heel of the foot
calcitonin
peptide hormone produced and secreted by the parafollicular cells (C cells) of the thyroid gland that functions to decrease blood calcium levels
callus
thickened area of skin that arises due to constant abrasion
calmodulin
regulatory protein that facilitates contraction in smooth muscles
calorie
amount of heat it takes to raise 1 kg (1000 g) of water by 1 °C
calvaria
(also, skullcap) rounded top of the skull
calyces
cup-like structures receiving urine from the collecting ducts where it passes on to the renal pelvis and ureter
canaliculi
(singular = canaliculus) channels within the bone matrix that house one of an osteocyte’s many cytoplasmic extensions that it uses to communicate and receive nutrients
capacitance
ability of a vein to distend and store blood
capacitance vessels
veins
capacitation
process that occurs in the female reproductive tract in which sperm are prepared for fertilization; leads to increased motility and changes in their outer membrane that improve their ability to release enzymes capable of digesting an oocyte’s outer layers
capillary
smallest of blood vessels where physical exchange occurs between the blood and tissue cells surrounded by interstitial fluid
capillary bed
network of 10–100 capillaries connecting arterioles to venules
capillary hydrostatic pressure (CHP)
force blood exerts against a capillary
capitate
from the lateral side, the third of the four distal carpal bones; articulates with the scaphoid and lunate proximally, the trapezoid laterally, the hamate medially, and primarily with the third metacarpal distally
capitulum
knob-like bony structure located anteriorly on the lateral, distal end of the humerus
capsaicin
molecule that activates nociceptors by interacting with a temperature-sensitive ion channel and is the basis for “hot” sensations in spicy food
carbaminohemoglobin
compound of carbon dioxide and hemoglobin
carbohydrate
class of organic compounds built from sugars, molecules containing carbon, hydrogen, and oxygen in a 1-2-1 ratio
carbonic anhydrase (CA)
enzyme that catalyzes the reaction that causes carbon dioxide and water to form carbonic acid
cardia
(also, cardiac region) part of the stomach surrounding the cardiac orifice (esophageal hiatus)
cardiac accelerator nerves
preganglionic sympathetic fibers that cause the heart rate to increase when the cardiovascular center in the medulla initiates a signal
cardiac cycle
period of time between the onset of atrial contraction (atrial systole) and ventricular relaxation (ventricular diastole)
cardiac muscle
striated muscle found in the heart; joined to one another at intercalated discs and under the regulation of pacemaker cells, which contract as one unit to pump blood through the circulatory system. Cardiac muscle is under involuntary control.
cardiac notch
depression in the medial surface of the inferior lobe of the left lung where the apex of the heart is located
cardiac output (CO)
amount of blood pumped by each ventricle during one minute; equals HR multiplied by SV
cardiac plexus
paired complex network of nerve fibers near the base of the heart that receive sympathetic and parasympathetic stimulations to regulate HR
cardiac reflexes
series of autonomic reflexes that enable the cardiovascular centers to regulate heart function based upon sensory information from a variety of visceral sensors
cardiac reserve
difference between maximum and resting CO
cardiac skeleton
(also, skeleton of the heart) reinforced connective tissue located within the atrioventricular septum; includes four rings that surround the openings between the atria and ventricles, and the openings to the pulmonary trunk and aorta; the point of attachment for the heart valves
cardiogenic area
area near the head of the embryo where the heart begins to develop 18–19 days after fertilization
cardiogenic cords
two strands of tissue that form within the cardiogenic area
cardiogenic shock
type of shock that results from the inability of the heart to maintain cardiac output
cardiomyocyte
muscle cell of the heart
cardiovascular center
region in the medulla that controls the cardiovascular system through cardiac accelerator nerves and vasomotor nerves, which are components of the sympathetic division of the autonomic nervous system
carotid canal
opening in the temporal bone through which the internal carotid artery enters the cranium
carotid sinuses
small pockets near the base of the internal carotid arteries that are the locations of the baroreceptors and chemoreceptors that trigger a reflex that aids in the regulation of vascular homeostasis
carpal bone
one of the eight small bones that form the wrist and base of the hand; these are grouped as a proximal row consisting of (from lateral to medial) the scaphoid, lunate, triquetrum, and pisiform bones, and a distal row containing (from lateral to medial) the trapezium, trapezoid, capitate, and hamate bones
carpal tunnel
passageway between the anterior forearm and hand formed by the carpal bones and flexor retinaculum
carpometacarpal joint
articulation between one of the carpal bones in the distal row and a metacarpal bone of the hand
carrier
heterozygous individual who does not display symptoms of a recessive genetic disorder but can transmit the disorder to his or her offspring
cartilage
semi-rigid connective tissue found on the skeleton in areas where flexibility and smooth surfaces support movement
cartilaginous joint
joint at which the bones are united by hyaline cartilage (synchondrosis) or fibrocartilage (symphysis)
catabolic hormones
hormones that stimulate the breakdown of larger molecules
catabolic reactions
reactions that break down larger molecules into their constituent parts
catagen
transitional phase marking the end of the anagen phase of the hair growth cycle
catalyst
substance that increases the rate of a chemical reaction without itself being changed in the process
cation
atom with a positive charge
cauda equina
bundle of spinal nerve roots that descend from the lower spinal cord below the first lumbar vertebra and lie within the vertebral cavity; has the appearance of a horse’s tail
caudal
describes a position below or lower than another part of the body proper; near or toward the tail (in humans, the coccyx, or lowest part of the spinal column); also referred to as inferior
caudate
nucleus deep in the cerebrum that is part of the basal nuclei; along with the putamen, it is part of the striatum
caval opening
opening in the diaphragm that allows the inferior vena cava to pass through; foramen for the vena cava
cavernous sinus
enlarged vein that receives blood from most of the other cerebral veins and the eye socket, and leads to the petrosal sinus
cecum
pouch forming the beginning of the large intestine
celiac ganglion
one of the collateral ganglia of the sympathetic system that projects to the digestive system
celiac trunk
(also, celiac artery) major branch of the abdominal aorta; gives rise to the left gastric artery, the splenic artery, and the common hepatic artery that forms the hepatic artery to the liver, the right gastric artery to the stomach, and the cystic artery to the gall bladder
cell
smallest independently functioning unit of all organisms; in animals, a cell contains cytoplasm, composed of fluid and organelles
cell junction
point of cell-to-cell contact that connects one cell to another in a tissue
cell membrane
membrane surrounding all animal cells, composed of a lipid bilayer interspersed with various molecules; also known as plasma membrane
cellular respiration
production of ATP from glucose oxidation via glycolysis, the Krebs cycle, and oxidative phosphorylation
cementum
bone-like tissue covering the root of a tooth
central canal of the neural tube
hollow space within the spinal cord that is the remnant of the center of the neural tube
central canal of the osteon
longitudinal channel in the center of each osteon; contains blood vessels, nerves, and lymphatic vessels; also known as the Haversian canal
central chemoreceptor
one of the specialized receptors that are located in the brain that sense changes in hydrogen ion, oxygen, or carbon dioxide concentrations in the brain
central nervous system (CNS)
anatomical division of the nervous system that includes the brain and spinal cord
central neuron
specifically referring to the cell body of a neuron in the autonomic system that is located in the central nervous system, specifically the lateral horn of the spinal cord or a brain stem nucleus
central sulcus
surface landmark of the cerebral cortex that marks the boundary between the frontal and parietal lobes
central tolerance
B cell tolerance induced in immature B cells of the bone marrow
central vein
vein that receives blood from hepatic sinusoids
centriole
small, self-replicating organelle that provides the origin for microtubule growth and moves DNA during cell division
centromere
region of attachment for two sister chromatids
centrosome
cellular structure that organizes microtubules during cell division
cephalic flexure
curve in midbrain of the embryo that positions the forebrain ventrally
cephalic phase
(also, reflex phase) initial phase of gastric secretion that occurs before food enters the stomach
cephalic vein
superficial vessel in the upper arm; leads to the axillary vein
cerebellum
region of the adult brain connected primarily to the pons that developed from the metencephalon (along with the pons) and is largely responsible for comparing information from the cerebrum with sensory feedback from the periphery through the spinal cord
cerebral aqueduct
connection of the ventricular system between the third and fourth ventricles located in the midbrain
cerebral cortex
outermost layer of gray matter of the cerebrum, marked by wrinkes and folds known as gyri and sulci; location of conscious perception
cerebral hemisphere
one half of the bilaterally symmetrical cerebrum
cerebral peduncles
segments of the descending motor pathway that make up the white matter of the ventral midbrain
cerebrocerebellum
lateral regions of the cerebellum; named for the significant input from the cerebral cortex
cerebrospinal fluid (CSF)
circulatory medium within the CNS that is produced by ependymal cells in the choroid plexus filtering the blood
cerebrovascular accident (CVA)
blockage of blood flow to the brain; also called a stroke
cerebrum
region of the adult brain that develops from the telencephalon and is responsible for higher neurological functions such as memory, emotion, and consciousness
cervical curvature
posteriorly concave curvature of the cervical vertebral column region; a secondary curve of the vertebral column
cervical enlargement
region of the ventral (anterior) horn of the spinal cord that has a larger population of motor neurons for the greater number of and finer control of muscles of the upper limb
cervical plexus
nerve plexus associated with the upper cervical spinal nerves
cervical vertebrae
seven vertebrae numbered as C1–C7 that are located in the neck region of the vertebral column
cervix
elongate inferior end of the uterus where it connects to the vagina
check reflex
response to a release in resistance so that the contractions stop, or check, movement
checkpoint
progress point in the cell cycle during which certain conditions must be met in order for the cell to proceed to a subsequence phase
chemical digestion
enzymatic breakdown of food
chemical energy
form of energy that is absorbed as chemical bonds form, stored as they are maintained, and released as they are broken
chemical synapse
connection between two neurons, or between a neuron and its target, where a neurotransmitter diffuses across a very short distance
chemokine
soluble, long-range, cell-to-cell communication molecule
chemoreceptor
sensory receptor cell that is sensitive to chemical stimuli, such as in taste, smell, or pain
chief cell
gastric gland cell that secretes pepsinogen
chief sensory nucleus
component of the trigeminal nuclei that is found in the pons
chloride shift
facilitated diffusion that exchanges bicarbonate (HCO3–) with chloride (Cl–) ions
cholecystokinin (CCK)
hormone that stimulates the release of pancreatic lipase and the contraction of the gallbladder to release bile salts
cholinergic
synapse at which acetylcholine is released and binds to the nicotinic or muscarinic receptor
cholinergic receptors
neurotransmitter system of acetylcholine, which includes its receptors and the enzyme acetylcholinesterase
chondrocytes
cells of the cartilage
chordae tendineae
string-like extensions of tough connective tissue that extend from the flaps of the atrioventricular valves to the papillary muscles
chorion
membrane that develops from the syncytiotrophoblast, cytotrophoblast, and mesoderm; surrounds the embryo and forms the fetal portion of the placenta through the chorionic villi
chorionic membrane
precursor to the chorion; forms from extra-embryonic mesoderm cells
chorionic villi
projections of the chorionic membrane that burrow into the endometrium and develop into the placenta
choroid
highly vascular tissue in the wall of the eye that supplies the outer retina with blood
choroid plexus
specialized structures containing ependymal cells lining blood capillaries that filter blood to produce CSF in the four ventricles of the brain
chromaffin
neuroendocrine cells of the adrenal medulla
chromaffin cells
neuroendocrine cells of the adrenal medulla that release epinephrine and norepinephrine into the bloodstream as part of sympathetic system activity
chromatin
substance consisting of DNA and associated proteins
chromosome
condensed version of chromatin
chronic inflammation
inflammation occurring for long periods of time
chronotropic factor
a factor that affects heart rate
chyle
lipid-rich lymph inside the lymphatic capillaries of the small intestine
chylomicron
large lipid-transport compound made up of triglycerides, phospholipids, cholesterol, and proteins
chylomicrons
vesicles containing cholesterol and triglycerides that transport lipids out of the intestinal cells and into the lymphatic and circulatory systems
chyme
soupy liquid created when food is mixed with digestive juices
chymotrypsin
pancreatic enzyme that digests protein
chymotrypsinogen
proenzyme that is activated by trypsin into chymotrypsin
cilia
small appendage on certain cells formed by microtubules and modified for movement of materials across the cellular surface
ciliary body
smooth muscle structure on the interior surface of the iris that controls the shape of the lens through the zonule fibers
ciliary ganglion
one of the terminal ganglia of the parasympathetic system, located in the posterior orbit, axons from which project to the iris
circadian rhythm
internal perception of the daily cycle of light and dark based on retinal activity related to sunlight
circle of Willis
unique anatomical arrangement of blood vessels around the base of the brain that maintains perfusion of blood into the brain even if one component of the structure is blocked or narrowed, ensuring continual blood supply to the brain
circular
(also, sphincter) fascicles that are concentrically arranged around an opening
circular fold
(also, plica circulare) deep fold in the mucosa and submucosa of the small intestine
circulatory shock
also simply called shock; a life-threatening medical condition in which the circulatory system is unable to supply enough blood flow to provide adequate oxygen and other nutrients to the tissues to maintain cellular metabolism
circumduction
circular motion of the arm, thigh, hand, thumb, or finger that is produced by the sequential combination of flexion, abduction, extension, and adduction
circumflex artery
branch of the left coronary artery that follows coronary sulcus
cisterna chyli
bag-like vessel that forms the beginning of the thoracic duct
citric acid cycle
also called the Krebs cycle or the tricarboxylic acid cycle; converts pyruvate into CO2 and high-energy FADH2, NADH, and ATP molecules
clasp-knife response
sign of UMN disease when a patient initially resists passive movement of a muscle but will quickly release to a lower state of resistance
class switching
ability of B cells to change the class of antibody they produce without altering the specificity for antigen
clavicle
collarbone; elongated bone that articulates with the manubrium of the sternum medially and the acromion of the scapula laterally
clavicular notch
paired notches located on the superior-lateral sides of the sternal manubrium, for articulation with the clavicle
cleavage
form of mitotic cell division in which the cell divides but the total volume remains unchanged; this process serves to produce smaller and smaller cells
cleavage furrow
contractile ring that forms around a cell during cytokinesis that pinches the cell into two halves
clitoris
(also, glans clitoris) nerve-rich area of the vulva that contributes to sexual sensation during intercourse
clonal anergy
process whereby B cells that react to soluble antigens in bone marrow are made nonfunctional
clonal deletion
removal of self-reactive B cells by inducing apoptosis
clonal expansion
growth of a clone of selected lymphocytes
clonal selection
stimulating growth of lymphocytes that have specific receptors
clone
group of lymphocytes sharing the same antigen receptor
closed reduction
manual manipulation of a broken bone to set it into its natural position without surgery
clotting
also called coagulation; complex process by which blood components form a plug to stop bleeding
clotting factors
group of 12 identified substances active in coagulation
coagulation
formation of a blood clot; part of the process of hemostasis
coccyx
small bone located at inferior end of the adult vertebral column that is formed by the fusion of four coccygeal vertebrae; also referred to as the “tailbone”
cochlea
auditory portion of the inner ear containing structures to transduce sound stimuli
cochlear duct
space within the auditory portion of the inner ear that contains the organ of Corti and is adjacent to the scala tympani and scala vestibuli on either side
codominance
pattern of inheritance that corresponds to the equal, distinct, and simultaneous expression of two different alleles
codon
consecutive sequence of three nucleotides on an mRNA molecule that corresponds to a specific amino acid
collagen fiber
flexible fibrous proteins that give connective tissue tensile strength
collateral ganglia
ganglia outside of the sympathetic chain that are targets of sympathetic preganglionic fibers, which are the celiac, inferior mesenteric, and superior mesenteric ganglia
colloid
viscous fluid in the central cavity of thyroid follicles, containing the glycoprotein thyroglobulin
colon
part of the large intestine between the cecum and the rectum
colony-stimulating factors (CSFs)
glycoproteins that trigger the proliferation and differentiation of myeloblasts into granular leukocytes (basophils, neutrophils, and eosinophils)
colostrum
thick, yellowish substance secreted from a mother’s breasts in the first postpartum days; rich in immunoglobulins
common bile duct
structure formed by the union of the common hepatic duct and the gallbladder’s cystic duct
common carotid artery
right common carotid artery arises from the brachiocephalic artery, and the left common carotid arises from the aortic arch; gives rise to the external and internal carotid arteries; supplies the respective sides of the head and neck
common hepatic artery
branch of the celiac trunk that forms the hepatic artery, the right gastric artery, and the cystic artery
common hepatic duct
duct formed by the merger of the two hepatic ducts
common iliac artery
branch of the aorta that leads to the internal and external iliac arteries
common iliac vein
one of a pair of veins that flows into the inferior vena cava at the level of L5; the left common iliac vein drains the sacral region; divides into external and internal iliac veins near the inferior portion of the sacroiliac joint
common pathway
final coagulation pathway activated either by the intrinsic or the extrinsic pathway, and ending in the formation of a blood clot
compact bone
dense osseous tissue that can withstand compressive forces
complement
enzymatic cascade of constitutive blood proteins that have antipathogen effects, including the direct killing of bacteria
compliance
degree to which a blood vessel can stretch as opposed to being rigid
compound
substance composed of two or more different elements joined by chemical bonds
compressor urethrae
deep perineal muscle in women
computed tomography (CT)
medical imaging technique in which a computer-enhanced cross-sectional X-ray image is obtained
concentration
number of particles within a given space
concentration gradient
difference in the concentration of a substance between two regions
concentric contraction
muscle contraction that shortens the muscle to move a load
conceptus
pre-implantation stage of a fertilized egg and its associated membranes
conducting zone
region of the respiratory system that includes the organs and structures that provide passageways for air and are not directly involved in gas exchange
conduction
transfer of heat through physical contact
conduction aphasia
loss of language function related to connecting the understanding of speech with the production of speech, without either specific function being lost
conductive hearing
hearing dependent on the conduction of vibrations of the tympanic membrane through the ossicles of the middle ear
condylar process of the mandible
thickened upward projection from posterior margin of mandibular ramus
condyle
oval-shaped process located at the top of the condylar process of the mandible
condyloid joint
synovial joint in which the shallow depression at the end of one bone receives a rounded end from a second bone or a rounded structure formed by two bones; found at the metacarpophalangeal joints of the fingers or the radiocarpal joint of the wrist; functionally classified as a biaxial joint
cone photoreceptor
one of the two types of retinal receptor cell that is specialized for color vision through the use of three photopigments distributed through three separate populations of cells
conjugate gaze
coordinated movement of the two eyes simultaneously in the same direction
connective tissue
type of tissue that serves to hold in place, connect, and integrate the body’s organs and systems
connective tissue membrane
connective tissue that encapsulates organs and lines movable joints
connective tissue proper
connective tissue containing a viscous matrix, fibers, and cells.
constant region domain
part of a lymphocyte antigen receptor that does not vary much between different receptor types
continuous capillary
most common type of capillary, found in virtually all tissues except epithelia and cartilage; contains very small gaps in the endothelial lining that permit exchange
continuous conduction
slow propagation of an action potential along an unmyelinated axon owing to voltage-gated Na+ channels located along the entire length of the cell membrane
contractility
ability to shorten (contract) forcibly
contraction phase
twitch contraction phase when tension increases
contralateral
word meaning “on the opposite side,” as in axons that cross the midline in a fiber tract
control center
compares values to their normal range; deviations cause the activation of an effector
convection
transfer of heat between the skin and air or water
convergence
in vision, the movement of the eyes so that they are both pointed at the same point in space, which increases for stimuli that are closer to the subject
convergent
fascicles that extend over a broad area and converge on a common attachment site
coracobrachialis
muscle that flexes and adducts the arm
coracoclavicular ligament
strong band of connective tissue that anchors the coracoid process of the scapula to the lateral clavicle; provides important indirect support for the acromioclavicular joint
coracohumeral ligament
intrinsic ligament of the shoulder joint; runs from the coracoid process of the scapula to the anterior humerus
coracoid process
short, hook-like process that projects anteriorly and laterally from the superior margin of the scapula
corn
type of callus that is named for its shape and the elliptical motion of the abrasive force
cornea
fibrous covering of the anterior region of the eye that is transparent so that light can pass through it
corneal reflex
protective response to stimulation of the cornea causing contraction of the orbicularis oculi muscle resulting in blinking of the eye
corona radiata
in an oocyte, a layer of granulosa cells that surrounds the oocyte and that must be penetrated by sperm before fertilization can occur
coronal suture
joint that unites the frontal bone to the right and left parietal bones across the top of the skull
coronary arteries
branches of the ascending aorta that supply blood to the heart; the left coronary artery feeds the left side of the heart, the left atrium and ventricle, and the interventricular septum; the right coronary artery feeds the right atrium, portions of both ventricles, and the heart conduction system
coronary sinus
large, thin-walled vein on the posterior surface of the heart that lies within the atrioventricular sulcus and drains the heart myocardium directly into the right atrium
coronary sulcus
sulcus that marks the boundary between the atria and ventricles
coronary veins
vessels that drain the heart and generally parallel the large surface arteries
coronoid fossa
depression on the anterior surface of the humerus above the trochlea; this space receives the coronoid process of the ulna when the elbow is maximally flexed
coronoid process of the mandible
flattened upward projection from the anterior margin of the mandibular ramus
coronoid process of the ulna
projecting bony lip located on the anterior, proximal ulna; forms the inferior margin of the trochlear notch
corpus albicans
nonfunctional structure remaining in the ovarian stroma following structural and functional regression of the corpus luteum
corpus callosum
large white matter structure that connects the right and left cerebral hemispheres
corpus cavernosum
either of two columns of erectile tissue in the penis that fill with blood during an erection
corpus luteum
transformed follicle after ovulation that secretes progesterone
corpus spongiosum
(plural = corpora cavernosa) column of erectile tissue in the penis that fills with blood during an erection and surrounds the penile urethra on the ventral portion of the penis
corrugator supercilii
prime mover of the eyebrows
cortex
in hair, the second or middle layer of keratinocytes originating from the hair matrix, as seen in a cross-section of the hair bulb
cortical nephrons
nephrons with loops of Henle that do not extend into the renal medulla
cortical reaction
following fertilization, the release of cortical granules from the oocyte’s plasma membrane into the zona pellucida creating a fertilization membrane that prevents any further attachment or penetration of sperm; part of the slow block to polyspermy
cortico-ponto-cerebellar pathway
projection from the cerebral cortex to the cerebellum by way of the gray matter of the pons
corticobulbar tract
connection between the cortex and the brain stem responsible for generating movement
corticospinal tract
connection between the cortex and the spinal cord responsible for generating movement
cortisol
glucocorticoid important in gluconeogenesis, the catabolism of glycogen, and downregulation of the immune system
costal cartilage
hyaline cartilage structure attached to the anterior end of each rib that provides for either direct or indirect attachment of most ribs to the sternum
costal facet
site on the lateral sides of a thoracic vertebra for articulation with the head of a rib
costal groove
shallow groove along the inferior margin of a rib that provides passage for blood vessels and a nerve
costoclavicular ligament
band of connective tissue that unites the medial clavicle with the first rib
countercurrent multiplier system
involves the descending and ascending loops of Henle directing forming urine in opposing directions to create a concentration gradient when combined with variable permeability and sodium pumping
covalent bond
chemical bond in which two atoms share electrons, thereby completing their valence shells
coxal bone
hip bone
cranial
describes a position above or higher than another part of the body proper; also referred to as superior
cranial cavity
division of the posterior (dorsal) cavity that houses the brain
cranial nerve
one of twelve nerves connected to the brain that are responsible for sensory or motor functions of the head and neck
cranial nerve ganglion
sensory ganglion of cranial nerves
craniosacral system
alternate name for the parasympathetic division of the autonomic nervous system that is based on the anatomical location of central neurons in brain-stem nuclei and the lateral horn of the sacral spinal cord; also referred to as craniosacral outflow
cranium
portion of skull enclosing the brain
creatine phosphate
phosphagen used to store energy from ATP and transfer it to muscle
cribriform plate
small, flattened areas with numerous small openings, located to either side of the midline in the floor of the anterior cranial fossa; formed by the ethmoid bone
cricoid cartilage
portion of the larynx composed of a ring of cartilage with a wide posterior region and a thinner anterior region; attached to the esophagus
crista galli
small upward projection located at the midline in the floor of the anterior cranial fossa; formed by the ethmoid bone
cross matching
blood test for identification of blood type using antibodies and small samples of blood
crossed extensor reflex
an innate, polysynaptic, intersegmental reflex arc; in association with withdrawal reflex, activation of contralateral limb muscles enables the other side of the body to respond, often to maintain balance
crown
portion of tooth visible superior to the gum line
cuboid
tarsal bone that articulates posteriorly with the calcaneus bone, medially with the lateral cuneiform bone, and anteriorly with the fourth and fifth metatarsal bones
cupula
specialized structure within the base of a semicircular canal that bends the stereocilia of hair cells when the head rotates by way of the relative movement of the enclosed fluid
cuspid
(also, canine) pointed tooth used for tearing and shredding food
cutaneous membrane
skin; epithelial tissue made up of stratified squamous epithelial cells that cover the outside of the body
cuticle
in hair, the outermost layer of keratinocytes originating from the hair matrix, as seen in a cross-section of the hair bulb
cyclic adenosine monophosphate (cAMP)
second messenger that, in response to adenylyl cyclase activation, triggers a phosphorylation cascade
cyclin
one of a group of proteins that function in the progression of the cell cycle
cyclin-dependent kinase (CDK)
one of a group of enzymes associated with cyclins that help them perform their functions
cystic artery
branch of the common hepatic artery; supplies blood to the gall bladder
cystic duct
duct through which bile drains and enters the gallbladder
cytokine
soluble, short-range, cell-to-cell communication molecule
cytokines
class of proteins that act as autocrine or paracrine signaling molecules; in the cardiovascular system, they stimulate the proliferation of progenitor cells and help to stimulate both nonspecific and specific resistance to disease
cytokinesis
final stage in cell division, where the cytoplasm divides to form two separate daughter cells
cytoplasm
internal material between the cell membrane and nucleus of a cell, mainly consisting of a water-based fluid called cytosol, within which are all the other organelles and cellular solute and suspended materials
cytoskeleton
“skeleton” of a cell; formed by rod-like proteins that support the cell’s shape and provide, among other functions, locomotive abilities
cytosol
clear, semi-fluid medium of the cytoplasm, made up mostly of water
Cytotoxic T cells (Tc)
T lymphocytes with the ability to induce apoptosis in target cells

D

Dalton’s law
statement of the principle that a specific gas type in a mixture exerts its own pressure, as if that specific gas type was not part of a mixture of gases
deciduous tooth
one of 20 “baby teeth”
decomposition reaction
type of catabolic reaction in which one or more bonds within a larger molecule are broken, resulting in the release of smaller molecules or atoms
decussate
to cross the midline, as in fibers that project from one side of the body to the other
deep
describes a position farther from the surface of the body
deep anterior compartment
flexor pollicis longus, flexor digitorum profundus, and their associated blood vessels and nerves
deep femoral artery
branch of the femoral artery; gives rise to the lateral circumflex arteries
deep femoral vein
drains blood from the deeper portions of the thigh and leads to the femoral vein
deep posterior compartment of the forearm
(deep posterior extensor compartment of the forearm) the abductor pollicis longus, extensor pollicis brevis, extensor pollicis longus, extensor indicis, and their associated blood vessels and nerves
deep tendon reflex
another term for stretch reflex, based on the elicitation through deep stimulation of the tendon at the insertion
deep transverse perineal
deep perineal muscle in men
defecation
elimination of undigested substances from the body in the form of feces
defensins
antimicrobial proteins released from neutrophils and macrophages that create openings in the plasma membranes to kill cells
deglutition
three-stage process of swallowing
dehydration
state of containing insufficient water in blood and other tissues
delayed hypersensitivity
(type IV) T cell-mediated immune response against pathogens infiltrating interstitial tissues, causing cellular infiltrate
delta cell
minor cell type in the pancreas that secretes the hormone somatostatin
deltoid
shoulder muscle that abducts the arm as well as flexes and medially rotates it, and extends and laterally rotates it
deltoid ligament
broad intrinsic ligament located on the medial side of the ankle joint; supports the talus at the talocrural joint and resists excess eversion of the foot
deltoid tuberosity
roughened, V-shaped region located laterally on the mid-shaft of the humerus
denaturation
change in the structure of a molecule through physical or chemical means
dendrite
one of many branchlike processes that extends from the neuron cell body and functions as a contact for incoming signals (synapses) from other neurons or sensory cells
dens of the mouth
tooth
dens of the vertebral column
bony projection (odontoid process) that extends upward from the body of the C2 (axis) vertebra
dense body
sarcoplasmic structure that attaches to the sarcolemma and shortens the muscle as thin filaments slide past thick filaments
dense connective tissue
connective tissue proper that contains many fibers that provide both elasticity and protection
dentin
bone-like tissue immediately deep to the enamel of the crown or cementum of the root of a tooth
dentition
set of teeth
deoxyhemoglobin
molecule of hemoglobin without an oxygen molecule bound to it
deoxyribonuclease
pancreatic enzyme that digests DNA
deoxyribonucleic acid (DNA)
deoxyribose-containing nucleotide that stores genetic information
depolarization
change in a cell membrane potential from rest toward zero
depolarize
to reduce the voltage difference between the inside and outside of a cell’s plasma membrane (the sarcolemma for a muscle fiber), making the inside less negative than at rest
depression
downward (inferior) motion of the scapula or mandible
dermal papilla
(plural = dermal papillae) extension of the papillary layer of the dermis that increases surface contact between the epidermis and dermis
dermis
layer of skin between the epidermis and hypodermis, composed mainly of connective tissue and containing blood vessels, hair follicles, sweat glands, and other structures
descending aorta
portion of the aorta that continues downward past the end of the aortic arch; subdivided into the thoracic aorta and the abdominal aorta
descending colon
part of the colon between the transverse colon and the sigmoid colon
descending tract
central nervous system fibers carrying motor commands from the brain to the spinal cord or periphery
desmosome
structure that forms an impermeable junction between cells
detrusor muscle
smooth muscle in the bladder wall; fibers run in all directions to reduce the size of the organ when emptying it of urine
diabetes mellitus
condition caused by destruction or dysfunction of the beta cells of the pancreas or cellular resistance to insulin that results in abnormally high blood glucose levels
diacylglycerol (DAG)
molecule that, like cAMP, activates protein kinases, thereby initiating a phosphorylation cascade
diapedesis
(also, emigration) process by which leukocytes squeeze through adjacent cells in a blood vessel wall to enter tissues
diaphragm
skeletal muscle that separates the thoracic and abdominal cavities and is dome-shaped at rest
diaphysis
tubular shaft that runs between the proximal and distal ends of a long bone
diarthrosis
freely mobile joint
diastole
period of time when the heart muscle is relaxed and the chambers fill with blood
diastolic pressure
lower number recorded when measuring arterial blood pressure; represents the minimal value corresponding to the pressure that remains during ventricular relaxation
diencephalon
region of the adult brain that retains its name from embryonic development and includes the thalamus and hypothalamus
diffusion
movement of a substance from an area of higher concentration to one of lower concentration
digastric
muscle that has anterior and posterior bellies and elevates the hyoid bone and larynx when one swallows; it also depresses the mandible
digital arteries
formed from the superficial and deep palmar arches; supply blood to the digits
digital veins
drain the digits and feed into the palmar arches of the hand and dorsal venous arch of the foot
dihydroxyvitamin D
active form of vitamin D required by the intestinal epithelial cells for the absorption of calcium
dilation
first stage of childbirth, involving an increase in cervical diameter
dipeptidase
brush border enzyme that acts on proteins
diploë
layer of spongy bone, that is sandwiched between two the layers of compact bone found in flat bones
diploid
condition marked by the presence of a double complement of genetic material (two sets of chromosomes, one set inherited from each of two parents)
diplopia
double vision resulting from a failure in conjugate gaze
direct pathway
connections within the basal nuclei from the striatum to the globus pallidus internal segment and substantia nigra pars reticulata that disinhibit the thalamus to increase cortical control of movement
disaccharide
pair of carbohydrate monomers bonded by dehydration synthesis via a glycosidic bond
disinhibition
disynaptic connection in which the first synapse inhibits the second cell, which then stops inhibiting the final target
distal
describes a position farther from the point of attachment or the trunk of the body
distal convoluted tubules
portions of the nephron distal to the loop of Henle that receive hyposmotic filtrate from the loop of Henle and empty into collecting ducts
distal radioulnar joint
articulation between the head of the ulna and the ulnar notch of the radius
distal tibiofibular joint
articulation between the distal fibula and the fibular notch of the tibia
disulfide bond
covalent bond formed within a polypeptide between sulfide groups of sulfur-containing amino acids, for example, cysteine
diuresis
excess production of urine
diuretic
compound that increases urine output, leading to decreased water conservation
DNA polymerase
enzyme that functions in adding new nucleotides to a growing strand of DNA during DNA replication
DNA replication
process of duplicating a molecule of DNA
dominant
describes a trait that is expressed both in homozygous and heterozygous form
dominant lethal
inheritance pattern in which individuals with one or two copies of a lethal allele do not survive in utero or have a shortened life span
dorsal
describes the back or direction toward the back of the body; also referred to as posterior
dorsal (posterior) nerve root
axons entering the posterior horn of the spinal cord
dorsal (posterior) root ganglion
sensory ganglion attached to the posterior nerve root of a spinal nerve
dorsal arch
(also, arcuate arch) formed from the anastomosis of the dorsalis pedis artery and medial and plantar arteries; branches supply the distal portions of the foot and digits
dorsal column system
ascending tract of the spinal cord associated with fine touch and proprioceptive sensations
dorsal interossei
muscles that abduct and flex the three middle fingers at the metacarpophalangeal joints and extend them at the interphalangeal joints
dorsal longitudinal fasciculus
major output pathway of the hypothalamus that descends through the gray matter of the brain stem and into the spinal cord
dorsal nucleus of the vagus nerve
location of parasympathetic neurons that project through the vagus nerve to terminal ganglia in the thoracic and abdominal cavities
dorsal respiratory group (DRG)
region of the medulla oblongata that stimulates the contraction of the diaphragm and intercostal muscles to induce inspiration
dorsal stream
connections between cortical areas from the occipital to parietal lobes that are responsible for the perception of visual motion and guiding movement of the body in relation to that motion
dorsal venous arch
drains blood from digital veins and vessels on the superior surface of the foot
dorsalis pedis artery
forms from the anterior tibial artery; branches repeatedly to supply blood to the tarsal and dorsal regions of the foot
dorsiflexion
movement at the ankle that brings the top of the foot toward the anterior leg
dorsum nasi
intermediate portion of the external nose that connects the bridge to the apex and is supported by the nasal bone
downregulation
decrease in the number of hormone receptors, typically in response to chronically excessive levels of a hormone
ductus arteriosus
shunt in the fetal pulmonary trunk that diverts oxygenated blood back to the aorta
ductus deferens
(also, vas deferens) duct that transports sperm from the epididymis through the spermatic cord and into the ejaculatory duct; also referred as the vas deferens
ductus venosus
shunt that causes oxygenated blood to bypass the fetal liver on its way to the inferior vena cava
duodenal gland
(also, Brunner’s gland) mucous-secreting gland in the duodenal submucosa
duodenum
first part of the small intestine, which starts at the pyloric sphincter and ends at the jejunum
dura mater
tough, fibrous, outer layer of the meninges that is attached to the inner surface of the cranium and vertebral column and surrounds the entire CNS
dural sinus
any of the venous structures surrounding the brain, enclosed within the dura mater, which drain blood from the CNS to the common venous return of the jugular veins

E

ear ossicles
three small bones located in the middle ear cavity that serve to transmit sound vibrations to the inner ear
early induced immune response
includes antimicrobial proteins stimulated during the first several days of an infection
eccentric contraction
muscle contraction that lengthens the muscle as the tension is diminished
eccrine sweat gland
type of sweat gland that is common throughout the skin surface; it produces a hypotonic sweat for thermoregulation
ectoderm
outermost of three embryonic germ layers from which the nervous systems, sensory organs, epidermis, hair, and nails form
ectopic pregnancy
implantation of an embryo outside of the uterus
eczema
skin condition due to an allergic reaction, which resembles a rash
edema
fluid accumulation in tissue; often associated with circulatory deficits
Edinger–Westphal nucleus
location of parasympathetic neurons that project to the ciliary ganglion
effector
organ that can cause a change in a value
effector protein
enzyme that catalyzes the generation of a new molecule, which acts as the intracellular mediator of the signal that binds to the receptor
effector T cells
immune cells with a direct, adverse effect on a pathogen
efferent arteriole
arteriole carrying blood from the glomerulus to the capillary beds around the convoluted tubules and loop of Henle; portion of the portal system
efferent branch
component of a reflex arc that represents the output, with the target being an effector, such as muscle or glandular tissue
efferent lymphatic vessels
lead out of a lymph node
effort
the point of force application, like a muscle attachment
effort arm
the distance between the fulcrum (joint) and the effort (muscle insertion)
ejaculatory duct
duct that connects the ampulla of the ductus deferens with the duct of the seminal vesicle at the prostatic urethra
ejection fraction
portion of the blood that is pumped or ejected from the heart with each contraction; mathematically represented by SV divided by EDV
elastase
pancreatic enzyme that digests protein
elastic artery
(also, conducting artery) artery with abundant elastic fibers located closer to the heart, which maintains the pressure gradient and conducts blood to smaller branches
elastic cartilage
type of cartilage, with elastin as the major protein, characterized by rigid support as well as elasticity
elastic fiber
fibrous protein within connective tissue that contains a high percentage of the protein elastin that allows the fibers to stretch and return to original size
elasticity
ability to stretch and rebound
elastin fibers
fibers made of the protein elastin that increase the elasticity of the dermis
elbow joint
joint located between the arm and forearm; formed by the articulations between the trochlea of the humerus and the trochlear notch of the ulna, and between the capitulum of the humerus and the head of the radius; includes the humeroulnar joint
electrical synapse
connection between two neurons, or any two electrically active cells, where ions flow directly through channels spanning their adjacent cell membranes
electrocardiogram (ECG)
surface recording of the electrical activity of the heart that can be used for diagnosis of irregular heart function; also abbreviated as EKG
electron
subatomic particle having a negative charge and nearly no mass; found orbiting the atom’s nucleus
electron shell
area of space a given distance from an atom’s nucleus in which electrons are grouped
electron transport chain (ETC)
ATP production pathway in which electrons are passed through a series of oxidation-reduction reactions that forms water and produces a proton gradient
eleidin
clear protein-bound lipid found in the stratum lucidum that is derived from keratohyalin and helps to prevent water loss
element
substance that cannot be created or broken down by ordinary chemical means
elevation
upward (superior) motion of the scapula or mandible
embolus
thrombus that has broken free from the blood vessel wall and entered the circulation
embryo
developing human during weeks 3–8
embryonic folding
process by which an embryo develops from a flat disc of cells to a three-dimensional shape resembling a cylinder
emigration
(also, diapedesis) process by which leukocytes squeeze through adjacent cells in a blood vessel wall to enter tissues
enamel
covering of the dentin of the crown of a tooth
encapsulated ending
configuration of a sensory receptor neuron with dendrites surrounded by specialized structures to aid in transduction of a particular type of sensation, such as the lamellated corpuscles in the deep dermis and subcutaneous tissue
end diastolic volume (EDV)
(also, preload) the amount of blood in the ventricles at the end of atrial systole just prior to ventricular contraction
end systolic volume (ESV)
amount of blood remaining in each ventricle following systole
endocardial tubes
stage in which lumens form within the expanding cardiogenic cords, forming hollow structures
endocardium
innermost layer of the heart lining the heart chambers and heart valves; composed of endothelium reinforced with a thin layer of connective tissue that binds to the myocardium
endochondral ossification
process in which bone forms by replacing hyaline cartilage
endocrine gland
tissue or organ that secretes hormones into the blood and lymph without ducts such that they may be transported to organs distant from the site of secretion
endocrine system
cells, tissues, and organs that secrete hormones as a primary or secondary function and play an integral role in normal bodily processes
endocytosis
import of material into the cell by formation of a membrane-bound vesicle
endoderm
innermost of three embryonic germ layers from which the gastrointestinal tract, liver, pancreas, and lungs form
endogenous
describes substance made in the human body
endogenous chemical
substance produced and released within the body to interact with a receptor protein
endometrium
inner lining of the uterus, part of which builds up during the secretory phase of the menstrual cycle and then sheds with menses
endomysium
loose, and well-hydrated connective tissue covering each muscle fiber in a skeletal muscle
endoneurium
innermost layer of connective tissue that surrounds individual axons within a nerve
endoplasmic reticulum (ER)
cellular organelle that consists of interconnected membrane-bound tubules, which may or may not be associated with ribosomes (rough type or smooth type, respectively)
endosteum
delicate membranous lining of a bone’s medullary cavity
endothelium
layer of smooth, simple squamous epithelium that lines the endocardium and blood vessels
energy-consuming phase
first phase of glycolysis, in which two molecules of ATP are necessary to start the reaction
energy-yielding phase
second phase of glycolysis, during which energy is produced
enteric plexus
neuronal plexus in the wall of the intestines, which is part of the enteric nervous system
enteroendocrine cell
gastric gland cell that releases hormones
enterohepatic circulation
recycling mechanism that conserves bile salts
enterokinase
enzyme located in the wall of the small intestine that activates trypsin
enteropeptidase
intestinal brush-border enzyme that activates trypsinogen to trypsin
enzyme
protein or RNA that catalyzes chemical reactions
eosinophils
granulocytes that stain with eosin; they release antihistamines and are especially active against parasitic worms
ependymal cells
glial cell type in the CNS responsible for producing cerebrospinal fluid
epiblast
upper layer of cells of the embryonic disc that forms from the inner cell mass; gives rise to all three germ layers
epicardial coronary arteries
surface arteries of the heart that generally follow the sulci
epicardium
innermost layer of the serous pericardium and the outermost layer of the heart wall
epicranial aponeurosis
(also, galea aponeurosis) flat broad tendon that connects the frontalis and occipitalis
epidermis
outermost tissue layer of the skin
epididymis
(plural = epididymides) coiled tubular structure in which sperm start to mature and are stored until ejaculation
epiglottis
leaf-shaped piece of elastic cartilage that is a portion of the larynx that swings to close the trachea during swallowing
epimysium
outer layer of connective tissue around a skeletal muscle
epinephrine
(also, adrenaline), primary and most potent catecholamine horomone secreted by the adrenal medulla into the bloodstream in response to short-term stress
epineurium
outermost layer of connective tissue that surrounds an entire nerve
epiphyseal line
completely ossified remnant of the epiphyseal plate
epiphyseal plate
(also, growth plate) junction between epiphysis and diaphysis in the metaphysis of a growing long bone where a sheet of hyaline cartilage is replaced by bone tissue as the organ grows in length
epiphysis
wide section at each end of a long bone; filled with spongy bone and red marrow
epiploic appendage
small sac of fat-filled visceral peritoneum attached to teniae coli
episiotomy
incision made in the posterior vaginal wall and perineum that facilitates vaginal birth
episodic memory
memory of specific events in an autobiographical sense
epithalamus
region of the diecephalon containing the pineal gland
epithelial membrane
epithelium attached to a layer of connective tissue
epithelial tissue
type of tissue that serves primarily as a covering or lining of body parts, protecting the body; it also functions in absorption, transport, and secretion
eponychium
nail fold that meets the proximal end of the nail body, also called the cuticle
equilibrium
sense of balance that includes sensations of position and movement of the head
erector spinae group
large muscle mass of the back; primary extensor of the vertebral column
erythroblastosis fetalis
disease of Rh factor-positive newborns in Rh-negative mothers with multiple Rh-positive children; resulting from the action of maternal antibodies against fetal blood
erythrocyte
(also, red blood cell) mature myeloid blood cell that is composed mostly of hemoglobin and functions primarily in the transportation of oxygen and carbon dioxide
erythropoietin (EPO)
glycoprotein horomone secreted primarily by kidneys in response to low oxygen level which triggers the bone marrow to produce red blood cells
esophageal artery
branch of the thoracic aorta; supplies blood to the esophagus
esophageal plexus
neuronal plexus in the wall of the esophagus that is part of the enteric nervous system
esophageal vein
drains the inferior portions of the esophagus and leads to the azygos vein
esophagus
muscular tube that runs from the pharynx to the stomach
estrogens
class of predominantly female sex hormones important for the development and growth of the female reproductive tract, secondary sex characteristics, the female reproductive cycle, and the maintenance of pregnancy
ethmoid air cell
one of several small, air-filled spaces located within the lateral sides of the ethmoid bone, between the orbit and upper nasal cavity
ethmoid bone
unpaired bone that forms the roof and upper, lateral walls of the nasal cavity, portions of the floor of the anterior cranial fossa and medial wall of orbit, and the upper portion of the nasal septum
evaporation
transfer of heat that occurs when water changes from a liquid to a gas
eversion
foot movement involving the intertarsal joints of the foot in which the bottom of the foot is turned laterally, away from the midline
excess post-exercise oxygen consumption (EPOC)
elevated oxygen consumption present at the end of an exercise bout that remains elevated until oxygen deficit is recovered and other disruptions to homeostasis have been rectified
exchange reaction
type of chemical reaction in which bonds are both formed and broken, resulting in the transfer of components
excitability
ability to undergo neural stimulation
excitable membrane
cell membrane that regulates the movement of ions so that an electrical signal can be generated
excitation-contraction coupling
sequence of events from motor neuron signaling to a skeletal muscle fiber to contraction of the fiber’s sarcomeres
excitatory postsynaptic potential (EPSP)
graded potential in the postsynaptic membrane that is the result of depolarization and makes an action potential more likely to occur
executive functions
cognitive processes of the prefrontal cortex that lead to directing goal-directed behavior, which is a precursor to executing motor commands
exocrine gland
group of epithelial cells that secrete substances through ducts that open to the skin or to internal body surfaces that lead to the exterior of the body
exocytosis
export of a substance out of a cell by formation of a membrane-bound vesicle
exogenous
describes substance made outside of the human body
exogenous chemical
substance from a source outside the body, whether it be another organism such as a plant or from the synthetic processes of a laboratory, that binds to a transmembrane receptor protein
exon
one of the coding regions of an mRNA molecule that remain after splicing
expiration
(also, exhalation) process that causes the air to leave the lungs
expiratory reserve volume (ERV)
amount of air that can be forcefully exhaled after a normal tidal exhalation
expressive aphasia
loss of the ability to produce language; usually associated with damage to Broca’s area in the frontal lobe
expulsion
second stage of childbirth, during which the mother bears down with contractions; this stage ends in birth
extensibility
ability to lengthen (extend)
extension
movement in the sagittal plane that increases the angle of a joint (straightens the joint); motion involving posterior bending of the vertebral column or returning to the upright position from a flexed position
extensor
muscle that increases the angle at the joint
extensor carpi radialis brevis
muscle that extends and abducts the hand at the wrist
extensor carpi ulnaris
muscle that extends and adducts the hand
extensor digiti minimi
muscle that extends the little finger
extensor digitorum
muscle that extends the hand at the wrist and the phalanges
extensor digitorum brevis
muscle that extends the toes
extensor digitorum longus
muscle that is lateral to the tibialis anterior
extensor hallucis longus
muscle that is partly deep to the tibialis anterior and extensor digitorum longus
extensor indicis
muscle that inserts onto the tendon of the extensor digitorum of the index finger
extensor pollicis brevis
muscle that inserts onto the base of the proximal phalanx of the thumb
extensor pollicis longus
muscle that inserts onto the base of the distal phalanx of the thumb
extensor radialis longus
muscle that extends and abducts the hand at the wrist
extensor retinaculum
band of connective tissue that extends over the dorsal surface of the hand
external acoustic meatus
ear canal opening located on the lateral side of the skull
external anal sphincter
voluntary skeletal muscle sphincter in the anal canal
external callus
collar of cartilage and bone that forms around the outside of a fracture
external carotid artery
arises from the common carotid artery; supplies blood to numerous structures within the face, lower jaw, neck, esophagus, and larynx
external ear
structures on the lateral surface of the head, including the auricle and the ear canal back to the tympanic membrane
external elastic membrane
membrane composed of elastic fibers that separates the tunica media from the tunica externa; seen in larger arteries
external iliac artery
branch of the common iliac artery that leaves the body cavity and becomes a femoral artery; supplies blood to the lower limbs
external iliac vein
formed when the femoral vein passes into the body cavity; drains the legs and leads to the common iliac vein
external intercostal
superficial intercostal muscles that raise the rib cage
external jugular vein
one of a pair of major veins located in the superficial neck region that drains blood from the more superficial portions of the head, scalp, and cranial regions, and leads to the subclavian vein
external nose
region of the nose that is easily visible to others
external oblique
superficial abdominal muscle with fascicles that extend inferiorly and medially
external occipital protuberance
small bump located at the midline on the posterior skull
external respiration
gas exchange that occurs in the alveoli
external root sheath
outer layer of the hair follicle that is an extension of the epidermis, which encloses the hair root
external urinary sphincter
skeletal muscle; must be relaxed consciously to void urine
exteroceptor
sensory receptor that is positioned to interpret stimuli from the external environment, such as photoreceptors in the eye or somatosensory receptors in the skin
extracellular fluid (ECF)
fluid exterior to cells; includes the interstitial fluid, blood plasma, and fluids found in other reservoirs in the body
extraocular muscles
six skeletal muscles that control eye movement within the orbit
extrapyramidal system
pathways between the brain and spinal cord that are separate from the corticospinal tract and are responsible for modulating the movements generated through that primary pathway
extrinsic eye muscles
originate outside the eye and insert onto the outer surface of the white of the eye, and create eyeball movement
extrinsic ligament
ligament located outside of the articular capsule of a synovial joint
extrinsic muscles of the hand
muscles that move the wrists, hands, and fingers and originate on the arm
extrinsic muscles of the tongue
muscles that are connected to other structures, such as the hyoid bone or the mandible, and control the position of the tongue
extrinsic pathway
initial coagulation pathway that begins with tissue damage and results in the activation of the common pathway

F

facet
small, flattened area on a bone for an articulation (joint) with another bone, or for muscle attachment
facial bones
fourteen bones that support the facial structures and form the upper and lower jaws and the hard palate
facial nerve
seventh cranial nerve; responsible for contraction of the facial muscles and for part of the sense of taste, as well as causing saliva production
facilitated diffusion
diffusion of a substance with the aid of a membrane protein
FADH2
high-energy molecule needed for glycolysis
false ribs
vertebrochondral ribs 8–12 whose costal cartilage either attaches indirectly to the sternum via the costal cartilage of the next higher rib or does not attach to the sternum at all
fas ligand
molecule expressed on cytotoxic T cells and NK cells that binds to the fas molecule on a target cell and induces it do undergo apoptosis
fascicle (of axons in nerves)
bundle of neuron axons surrounded by perineurium
fascicle (of muscle)
bundle of skeletal muscle fibers surrounded by perimysium
fasciculation
small muscle twitch as a result of spontaneous activity from an LMN
fasciculus cuneatus
lateral division of the dorsal column system composed of fibers from sensory neurons in the upper body
fasciculus gracilis
medial division of the dorsal column system composed of fibers from sensory neurons in the lower body
fast glycolytic fiber
muscle fiber that primarily uses anaerobic glycolysis
fast oxidative fiber
intermediate muscle fiber that is between slow oxidative and fast glycolytic fibers
fatty acid oxidation
breakdown of fatty acids into smaller chain fatty acids and acetyl CoA
fauces
opening in the posterior oral cavity that connects the oral cavity to the oropharynx
Fc region
in an antibody molecule, the site where the two termini of the heavy chains come together; many cells have receptors for this portion of the antibody, adding functionality to these molecules
feces
semisolid waste product of digestion
femoral artery
continuation of the external iliac artery after it passes through the body cavity; divides into several smaller branches, the lateral deep femoral artery, and the genicular artery; becomes the popliteal artery as it passes posterior to the knee
femoral circumflex vein
forms a loop around the femur just inferior to the trochanters; drains blood from the areas around the head and neck of the femur; leads to the femoral vein
femoral nerve
systemic nerve of the anterior leg that arises from the lumbar plexus
femoral triangle
region formed at the junction between the hip and the leg and includes the pectineus, femoral nerve, femoral artery, femoral vein, and deep inguinal lymph nodes
femoral vein
drains the upper leg; receives blood from the great saphenous vein, the deep femoral vein, and the femoral circumflex vein; becomes the external iliac vein when it crosses the body wall
femoropatellar joint
portion of the knee joint consisting of the articulation between the distal femur and the patella
femur
thigh bone; the single bone of the thigh
fenestrated capillary
type of capillary with pores or fenestrations in the endothelium that allow for rapid passage of certain small materials
fenestrations
small windows through a cell, allowing rapid filtration based on size; formed in such a way as to allow substances to cross through a cell without mixing with cell contents
ferritin
protein-containing storage form of iron found in the bone marrow, liver, and spleen
fertilization
unification of genetic material from male and female haploid gametes
fertilization membrane
impenetrable barrier that coats a nascent zygote; part of the slow block to polyspermy
fetus
developing human during the time from the end of the embryonic period (week 9) to birth
fibrillation
in motor responses, a spontaneous muscle action potential that occurs in the absence of neuromuscular input, resulting from LMN lesions
fibrin
insoluble, filamentous protein that forms the structure of a blood clot
fibrinogen
plasma protein produced in the liver and involved in blood clotting
fibrinolysis
gradual degradation of a blood clot
fibroblast
most abundant cell type in connective tissue, secretes protein fibers and matrix into the extracellular space
fibrocartilage
tough form of cartilage, made of thick bundles of collagen fibers embedded in chondroitin sulfate ground substance
fibroelastic membrane
specialized membrane that connects the ends of the C-shape cartilage in the trachea; contains smooth muscle fibers
fibrosis
replacement of muscle fibers by scar tissue
fibrous joint
joint where the articulating areas of the adjacent bones are connected by fibrous connective tissue
fibrous tunic
outer layer of the eye primarily composed of connective tissue known as the sclera and cornea
fibula
thin, non-weight-bearing bone found on the lateral side of the leg
fibular collateral ligament
extrinsic ligament of the knee joint that spans from the lateral epicondyle of the femur to the head of the fibula; resists hyperextension and rotation of the extended knee
fibular nerve
systemic nerve of the posterior leg that begins as part of the sciatic nerve
fibular notch
wide groove on the lateral side of the distal tibia for articulation with the fibula at the distal tibiofibular joint
fibular vein
drains the muscles and integument near the fibula and leads to the popliteal vein
fibularis brevis
(also, peroneus brevis) muscle that plantar flexes the foot at the ankle and everts it at the intertarsal joints
fibularis longus
(also, peroneus longus) muscle that plantar flexes the foot at the ankle and everts it at the intertarsal joints
fibularis tertius
small muscle that is associated with the extensor digitorum longus
fight-or-flight response
set of responses induced by sympathetic activity that lead to either fleeing a threat or standing up to it, which in the modern world is often associated with anxious feelings
filling time
duration of ventricular diastole during which filling occurs
filtrate
a plasma-like liquid (lacking most proteins) formed by the glomerulus and modified through secretion and reabsorption before true urine is produced
filtration
in the cardiovascular system, the movement of material from a capillary into the interstitial fluid, moving from an area of higher pressure to lower pressure
filtration slits
formed by pedicels of podocytes; substances filter between the pedicels based on size
fimbriae
fingerlike projections on the distal uterine tubes
first messenger
hormone that binds to a cell membrane hormone receptor and triggers activation of a second messenger system
first-degree burn
superficial burn that injures only the epidermis
fixator
synergist that assists an agonist by preventing or reducing movement at another joint, thereby stabilizing the origin of the agonist
flaccid paralysis
loss of voluntary muscle control and muscle tone, as the result of LMN disease
flaccidity
presentation of a loss of muscle tone, observed as floppy limbs or a lack of resistance to passive movement
flagellum
appendage on certain cells formed by microtubules and modified for movement
flat bone
thin and curved bone; serves as a point of attachment for muscles and protects internal organs
flatus
gas in the intestine
flavin adenine dinucleotide (FAD)
coenzyme used to produce FADH2
flexion
movement that decreases the angle between articulating bones
flexor
muscle that decreases the angle at the joint
flexor carpi radialis
muscle that flexes and abducts the hand at the wrist
flexor carpi ulnaris
muscle that flexes and adducts the hand at the wrist
flexor digiti minimi brevis
muscle that flexes the little finger
flexor digitorum longus
muscle that flexes the four small toes
flexor digitorum profundus
muscle that flexes the phalanges of the fingers and the hand at the wrist
flexor digitorum superficialis
muscle that flexes the hand and the digits
flexor hallucis longus
muscle that flexes the big toe
flexor pollicis brevis
muscle that flexes the thumb
flexor pollicis longus
muscle that flexes the distal phalanx of the thumb
flexor retinaculum
strong band of connective tissue at the anterior wrist that spans the top of the U-shaped grouping of the carpal bones to form the roof of the carpal tunnel
flexor withdrawal reflex
an innate, polysynaptic reflex; nociceptor activation triggers ipsilateral muscle activation to immediately withdraw from painful stimulus
floating ribs
vertebral ribs 11–12 that do not attach to the sternum or to the costal cartilage of another rib
flocculonodular lobe
lobe of the cerebellum that receives input from the vestibular system to help with balance and posture
fluid compartment
fluid inside all cells of the body constitutes a compartment system that is largely segregated from other systems
fluid connective tissue
specialized cells that circulate in a watery fluid containing salts, nutrients, and dissolved proteins
follicle
ovarian structure of one oocyte and surrounding granulosa (and later theca) cells
follicle-stimulating hormone (FSH)
anterior pituitary hormone that stimulates the production and maturation of sex cells
folliculogenesis
development of ovarian follicles from primordial to tertiary under the stimulation of gonadotropins
fontanelle
expanded areas of fibrous connective tissue that separate the braincase bones of the skull prior to birth and during the first year after birth
foot
portion of the lower limb located distal to the ankle joint
foramen lacerum
irregular opening in the base of the skull, located inferior to the exit of carotid canal
foramen magnum
large opening in the occipital bone of the skull through which the spinal cord emerges and the vertebral arteries enter the cranium
foramen ovale
opening in the fetal heart that allows blood to flow directly from the right atrium to the left atrium, bypassing the fetal pulmonary circuit
foramen ovale of the middle cranial fossa
oval-shaped opening in the floor of the middle cranial fossa
foramen rotundum
round opening in the floor of the middle cranial fossa, located between the superior orbital fissure and foramen ovale
foramen spinosum
small opening in the floor of the middle cranial fossa, located lateral to the foramen ovale
forced breathing
(also, hyperpnea) mode of breathing that occurs during exercise or by active thought that requires muscle contraction for both inspiration and expiration
forearm
region of the upper limb located between the elbow and wrist joints; contains the radius and ulna bones
forebrain
anterior region of the adult brain that develops from the prosencephalon and includes the cerebrum and diencephalon
foregut
endoderm of the embryo towards the head region
foremilk
watery, translucent breast milk that is secreted first during a feeding and is rich in lactose and protein; quenches the infant’s thirst
formed elements
cellular components of blood; that is, erythrocytes, leukocytes, and platelets
fossa
(plural = fossae) shallow depression on the surface of a bone
fossa ovalis
oval-shaped depression in the interatrial septum that marks the former location of the foramen ovale
fourth ventricle
the portion of the ventricular system that is in the region of the brain stem and opens into the subarachnoid space through the median and lateral apertures
fourth-degree burn
burn in which full thickness of the skin and underlying muscle and bone is damaged
fovea
exact center of the retina at which visual stimuli are focused for maximal acuity, where the retina is thinnest, at which there is nothing but photoreceptors
fovea capitis
minor indentation on the head of the femur that serves as the site of attachment for the ligament to the head of the femur
fracture
broken bone
fracture hematoma
blood clot that forms at the site of a broken bone due to broken blood vessels
Frank-Starling mechanism
relationship between ventricular stretch and contraction in which the force of heart contraction is directly proportional to the initial length of the muscle fiber
free nerve ending
configuration of a sensory receptor neuron with dendrites in the connective tissue of the organ, such as in the dermis of the skin, that are most often sensitive to chemical, thermal, and mechanical stimuli
frontal bone
unpaired bone that forms forehead, roof of orbit, and floor of anterior cranial fossa
frontal eye field
region of the frontal lobe associated with motor commands to orient the eyes toward an object of visual attention
frontal eye fields
area of the prefrontal cortex responsible for moving the eyes to attend to visual stimuli
frontal lobe
region of the cerebral cortex directly beneath the frontal bone of the cranium
frontal plane
two-dimensional, vertical plane that divides the body or organ into anterior and posterior portions
frontal sinus
air-filled space within the frontal bone; most anterior of the paranasal sinuses
frontalis
front part of the occipitofrontalis muscle
fulcrum
an axis of rotation, like a joint
functional group
group of atoms linked by strong covalent bonds that tends to behave as a distinct unit in chemical reactions with other atoms
functional residual capacity (FRC)
sum of ERV and RV, which is the amount of air that remains in the lungs after a tidal expiration
fundus of the stomach
dome-shaped region of the stomach above and to the left of the cardia
fundus of the uterus
domed portion of the uterus that is superior to the uterine tubes
fusiform
muscle that has fascicles that are spindle-shaped to create large bellies

G

G cell
gastrin-secreting enteroendocrine cell
G protein
guanosine triphosphate (GTP) hydrolase that physically moves upon activation from the associated transmembrane receptor protein to the effector protein to initiate a second messenger system.
G protein–coupled receptor
membrane protein complex that consists of a receptor protein that binds to a signaling molecule—a G protein—that is activated by that binding and in turn activates an effector protein (enzyme) that creates a second-messenger molecule in the cytoplasm of the target cell
G0 phase
phase of the cell cycle, usually entered from the G1 phase; characterized by long or permanent periods where the cell does not move forward into the DNA synthesis phase
G1 phase
first phase of the cell cycle, after a new cell is born
G2 phase
third phase of the cell cycle, after the DNA synthesis phase
gait
rhythmic pattern of alternating movements of the lower limbs during locomotion
gallbladder
accessory digestive organ that stores and concentrates bile
ganglion
localized collection of neuron cell bodies in the peripheral nervous system
ganglionic neuron
specifically refers to the cell body of a neuron in the autonomic system that is located in a ganglion
gap junction
allows cytoplasmic communications to occur between cells
gastric emptying
process by which mixing waves gradually cause the release of chyme into the duodenum
gastric gland
gland in the stomach mucosal epithelium that produces gastric juice
gastric phase
phase of gastric secretion that begins when food enters the stomach
gastric pit
narrow channel formed by the epithelial lining of the stomach mucosa
gastric plexuses
neuronal networks in the wall of the stomach that are part of the enteric nervous system
gastrin
peptide hormone that stimulates secretion of hydrochloric acid and gut motility
gastrocnemius
most superficial muscle of the calf
gastrocolic reflex
propulsive movement in the colon activated by the presence of food in the stomach
gastroileal reflex
long reflex that increases the strength of segmentation in the ileum
gastrulation
process of cell migration and differentiation into three primary germ layers following cleavage and implantation
gated
property of a channel that determines how it opens under specific conditions, such as voltage change or physical deformation
gene
functional length of DNA that provides the genetic information necessary to build a protein
gene expression
active interpretation of the information coded in a gene to produce a functional gene product
general adaptation syndrome (GAS)
the human body’s three-stage response pattern to short- and long-term stress
general sense
any sensory system that is distributed throughout the body and incorporated into organs of multiple other systems, such as the walls of the digestive organs or the skin
generator potential
graded potential from dendrites of a unipolar cell which generates the action potential in the initial segment of that cell’s axon
genicular artery
branch of the femoral artery; supplies blood to the region of the knee
genioglossus
muscle that originates on the mandible and allows the tongue to move downward and forward
geniohyoid
muscle that depresses the mandible, and raises and pulls the hyoid bone anteriorly
genome
entire complement of an organism’s DNA; found within virtually every cell
genotype
complete genetic makeup of an individual
germinal centers
clusters of rapidly proliferating B cells found in secondary lymphoid tissues
gestation
in human development, the period required for embryonic and fetal development in utero; pregnancy
gigantism
disorder in children caused when abnormally high levels of GH prompt excessive growth
gingiva
gum
glabella
slight depression of frontal bone, located at the midline between the eyebrows
glans penis
bulbous end of the penis that contains a large number of nerve endings
glassy membrane
layer of connective tissue that surrounds the base of the hair follicle, connecting it to the dermis
glenohumeral joint
(also, shoulder joint) formed by the articulation between the glenoid cavity of the scapula and the head of the humerus; multiaxial ball-and-socket joint that allows for flexion/extension, abduction/adduction, circumduction, and medial/lateral rotation of the humerus
glenohumeral ligament
one of the three intrinsic ligaments of the shoulder joint that strengthen the anterior articular capsule
glenoid cavity
(also, glenoid fossa) shallow depression located on the lateral scapula, between the superior and lateral borders
glenoid labrum
lip of fibrocartilage located around the outside margin of the glenoid cavity of the scapula
glial cell
one of the various types of neural tissue cells responsible for maintenance of the tissue, and largely responsible for supporting neurons
globin
heme-containing globular protein that is a constituent of hemoglobin
globulins
heterogeneous group of plasma proteins that includes transport proteins, clotting factors, immune proteins, and others
globus pallidus
nuclei deep in the cerebrum that are part of the basal nuclei and can be divided into the internal and external segments
glomerular filtration rate (GFR)
rate of renal filtration
glomerulus
tuft of capillaries surrounded by Bowman’s capsule; filters the blood based on size
glossopharyngeal nerve
ninth cranial nerve; responsible for contraction of muscles in the tongue and throat and for part of the sense of taste, as well as causing saliva production
glottis
opening between the vocal folds through which air passes when producing speech
glucagon
pancreatic hormone that stimulates the catabolism of glycogen to glucose, thereby increasing blood glucose levels
glucocorticoids
hormones produced by the zona fasciculata of the adrenal cortex that influence glucose metabolism
glucokinase
cellular enzyme, found in the liver, which converts glucose into glucose-6-phosphate upon uptake into the cell
gluconeogenesis
process of glucose synthesis from pyruvate or other molecules
glucose-6-phosphate
phosphorylated glucose produced in the first step of glycolysis
gluteal group
muscle group that extends, flexes, rotates, adducts, and abducts the femur
gluteal tuberosity
roughened area on the posterior side of the proximal femur, extending inferiorly from the base of the greater trochanter
gluteus maximus
largest of the gluteus muscles that extends the femur
gluteus medius
muscle deep to the gluteus maximus that abducts the femur at the hip
gluteus minimus
smallest of the gluteal muscles and deep to the gluteus medius
glycocalyx
coating of sugar molecules that surrounds the cell membrane
glycogen
form that glucose assumes when it is stored
glycolysis
series of anaerobic, metabolic reactions that breaks down glucose into pyruvate and produces ATP
glycoprotein
protein that has one or more carbohydrates attached
glycosuria
presence of glucose in the urine; caused by high blood glucose levels that exceed the ability of the kidneys to reabsorb the glucose; usually the result of untreated or poorly controlled diabetes mellitus
gnosis
in a neurological exam, intuitive experiential knowledge tested by interacting with common objects or symbols
goblet cell
unicellular gland found in columnar epithelium that secretes mucous
goiter
enlargement of the thyroid gland either as a result of iodine deficiency or hyperthyroidism
Golgi apparatus
cellular organelle formed by a series of flattened, membrane-bound sacs that functions in protein modification, tagging, packaging, and transport
golgi tendon organ
located in tendon; the specific sensory receptors responsible for providing information about tendon length or the rate of change of the length; a mechanoreceptor & proprioceptor; involved in tendon reflex
golgi tendon reflex
an innate, polysynaptic reflex; tendon stretch causes the muscle pulling the tendon to relax (ipsilateral)
gomphosis
type of fibrous joint in which the root of a tooth is anchored into its bony jaw socket by strong periodontal ligaments
gonadal artery
branch of the abdominal aorta; supplies blood to the gonads or reproductive organs; also described as ovarian arteries or testicular arteries, depending upon the sex of the individual
gonadal vein
generic term for a vein draining a reproductive organ; may be either an ovarian vein or a testicular vein, depending on the sex of the individual
gonadotropin-releasing hormone (GnRH)
hormone released by the hypothalamus that regulates the production of follicle-stimulating hormone and luteinizing hormone from the pituitary gland
gonadotropins
hormones that regulate the function of the gonads
gonads
reproductive organs (testes in men and ovaries in women) that produce gametes and reproductive hormones
gracilis
muscle that adducts the thigh and flexes the leg at the knee
graded muscle response
modification of contraction strength
graded potential
change in the membrane potential that varies in size, depending on the size of the stimulus that elicits it
graft-versus-host disease
in bone marrow transplants; occurs when the transplanted cells mount an immune response against the recipient
granular leukocytes
leukocytes with abundant granules in their cytoplasm; specifically, neutrophils, eosinophils, and basophils
granulosa cells
supportive cells in the ovarian follicle that produce estrogen
granzyme
apoptosis-inducing substance contained in granules of NK cells and cytotoxic T cells
graphesthesia
perception of symbols, such as letters or numbers, traced in the palm of the hand
gray matter
regions of the nervous system containing cell bodies of neurons with few or no myelinated axons; actually may be more pink or tan in color, but called gray in contrast to white matter
gray rami communicantes
(singular = ramus communicans) unmyelinated structures that provide a short connection from a sympathetic chain ganglion to the spinal nerve that contains the postganglionic sympathetic fiber
great cardiac vein
vessel that follows the interventricular sulcus on the anterior surface of the heart and flows along the coronary sulcus into the coronary sinus on the posterior surface; parallels the anterior interventricular artery and drains the areas supplied by this vessel
great cerebral vein
receives most of the smaller vessels from the inferior cerebral veins and leads to the straight sinus
great saphenous vein
prominent surface vessel located on the medial surface of the leg and thigh; drains the superficial portions of these areas and leads to the femoral vein
greater pelvis
(also, greater pelvic cavity or false pelvis) broad space above the pelvic brim defined laterally by the fan-like portion of the upper ilium
greater sciatic foramen
pelvic opening formed by the greater sciatic notch of the hip bone, the sacrum, and the sacrospinous ligament
greater sciatic notch
large, U-shaped indentation located on the posterior margin of the ilium, superior to the ischial spine
greater splanchnic nerve
nerve that contains fibers of the central sympathetic neurons that do not synapse in the chain ganglia but project onto the celiac ganglion
greater trochanter
large, bony expansion of the femur that projects superiorly from the base of the femoral neck
greater tubercle
enlarged prominence located on the lateral side of the proximal humerus
greater wings of the sphenoid bone
lateral projections of the sphenoid bone that form the anterior wall of the middle cranial fossa and an area of the lateral skull
gross anatomy
study of the larger structures of the body, typically with the unaided eye; also referred to as macroscopic anatomy
ground substance
fluid or semi-fluid portion of the matrix
growth hormone (GH)
anterior pituitary hormone that promotes tissue building and influences nutrient metabolism (also called somatotropin)
gustation
sense of taste
gustatory receptor cells
sensory cells in the taste bud that transduce the chemical stimuli of gustation
gyrus
ridge formed by convolutions on the surface of the cerebrum or cerebellum

H

hair
keratinous filament growing out of the epidermis
hair bulb
structure at the base of the hair root that surrounds the dermal papilla
hair cells
mechanoreceptor cells found in the inner ear that transduce stimuli for the senses of hearing and balance
hair follicle
cavity or sac from which hair originates
hair matrix
layer of basal cells from which a strand of hair grows
hair papilla
mass of connective tissue, blood capillaries, and nerve endings at the base of the hair follicle
hair root
part of hair that is below the epidermis anchored to the follicle
hair shaft
part of hair that is above the epidermis but is not anchored to the follicle
Haldane effect
relationship between the partial pressure of oxygen and the affinity of hemoglobin for carbon dioxide
hallux
big toe; digit 1 of the foot
hamate
from the lateral side, the fourth of the four distal carpal bones; articulates with the lunate and triquetrum proximally, the fourth and fifth metacarpals distally, and the capitate laterally
hamstring group
three long muscles on the back of the leg
hand
region of the upper limb distal to the wrist joint
hard palate
bony structure that forms the roof of the mouth and floor of the nasal cavity, formed by the palatine process of the maxillary bones and the horizontal plate of the palatine bones
haustral contraction
slow segmentation in the large intestine
haustrum
small pouch in the colon created by tonic contractions of teniae coli
head of the femur
rounded, proximal end of the femur that articulates with the acetabulum of the hip bone to form the hip joint
head of the fibula
small, knob-like, proximal end of the fibula; articulates with the inferior aspect of the lateral condyle of the tibia
head of the humerus
smooth, rounded region on the medial side of the proximal humerus; articulates with the glenoid fossa of the scapula to form the glenohumeral (shoulder) joint
head of the metatarsal bone
expanded, distal end of each metatarsal bone
head of the radius
disc-shaped structure that forms the proximal end of the radius; articulates with the capitulum of the humerus as part of the elbow joint, and with the radial notch of the ulna as part of the proximal radioulnar joint
head of the rib
posterior end of a rib that articulates with the bodies of thoracic vertebrae
head of the ulna
small, rounded distal end of the ulna; articulates with the ulnar notch of the distal radius, forming the distal radioulnar joint
heart block
interruption in the normal conduction pathway
heart bulge
prominent feature on the anterior surface of the heart, reflecting early cardiac development
heart rate (HR)
number of times the heart contracts (beats) per minute
heart sounds
sounds heard via auscultation with a stethoscope of the closing of the atrioventricular valves (“lub”) and semilunar valves (“dub”)
heavy chain
larger protein chain of an antibody
helicase
enzyme that functions to separate the two DNA strands of a double helix during DNA replication
helper T cells (Th)
T cells that secrete cytokines to enhance other immune responses, involved in activation of both B and T cell lymphocytes
hemangioblasts
embryonic stem cells that appear in the mesoderm and give rise to both angioblasts and pluripotent stem cells
hematocrit
(also, packed cell volume) volume percentage of erythrocytes in a sample of centrifuged blood
hematopoiesis
production of blood cells, which occurs in the red marrow of the bones
heme
red, iron-containing pigment to which oxygen binds in hemoglobin
hemiazygos vein
smaller vein complementary to the azygos vein; drains the esophageal veins from the esophagus and the left intercostal veins, and leads to the brachiocephalic vein via the superior intercostal vein
hemisection
cut through half of a structure, such as the spinal cord
hemocytoblast
hemopoietic stem cell that gives rise to the formed elements of blood
hemoglobin
oxygen-carrying compound in erythrocytes
hemolysis
destruction (lysis) of erythrocytes and the release of their hemoglobin into circulation
hemolytic disease of the newborn (HDN)
(also, erythroblastosis fetalis) disorder causing agglutination and hemolysis in an Rh+ fetus or newborn of an Rh− mother
hemophilia
genetic disorder characterized by inadequate synthesis of clotting factors
hemopoiesis
production of the formed elements of blood
hemopoietic growth factors
chemical signals including erythropoietin, thrombopoietin, colony-stimulating factors, and interleukins that regulate the differentiation and proliferation of particular blood progenitor cells
hemopoietic stem cell
type of pluripotent stem cell that gives rise to the formed elements of blood (hemocytoblast)
hemorrhage
excessive bleeding
hemorrhagic stroke
disruption of blood flow to the brain caused by bleeding within the cranial vault
hemosiderin
protein-containing storage form of iron found in the bone marrow, liver, and spleen
hemostasis
physiological process by which bleeding ceases
Henry’s law
statement of the principle that the concentration of gas in a liquid is directly proportional to the solubility and partial pressure of that gas
heparin
short-acting anticoagulant stored in mast cells and released when tissues are injured, opposes prothrombin
hepatic artery
artery that supplies oxygenated blood to the liver
hepatic artery proper
branch of the common hepatic artery; supplies systemic blood to the liver
hepatic lobule
hexagonal-shaped structure composed of hepatocytes that radiate outward from a central vein
hepatic portal system
specialized circulatory pathway that carries blood from digestive organs to the liver for processing before being sent to the systemic circulation
hepatic portal vein
vein that supplies deoxygenated nutrient-rich blood to the liver
hepatic sinusoid
blood capillaries between rows of hepatocytes that receive blood from the hepatic portal vein and the branches of the hepatic artery
hepatic vein
vein that drains blood from the liver into the inferior vena cava
hepatocyte
major functional cells of the liver
hepatopancreatic ampulla
(also, ampulla of Vater) bulb-like point in the wall of the duodenum where the bile duct and main pancreatic duct unite
hepatopancreatic sphincter
(also, sphincter of Oddi) sphincter regulating the flow of bile and pancreatic juice into the duodenum
heterozygous
having two different alleles for a given gene
hexokinase
cellular enzyme, found in most tissues, that converts glucose into glucose-6-phosphate upon uptake into the cell
high endothelial venules
vessels containing unique endothelial cells specialized to allow migration of lymphocytes from the blood to the lymph node
hilum
concave structure on the mediastinal surface of the lungs where blood vessels, lymphatic vessels, nerves, and a bronchus enter the lung
hindbrain
posterior region of the adult brain that develops from the rhombencephalon and includes the pons, medulla oblongata, and cerebellum
hindmilk
opaque, creamy breast milk delivered toward the end of a feeding; rich in fat; satisfies the infant’s appetite
hinge joint
synovial joint at which the convex surface of one bone articulates with the concave surface of a second bone; includes the elbow, knee, ankle, and interphalangeal joints; functionally classified as a uniaxial joint
hip bone
coxal bone; single bone that forms the pelvic girdle; consists of three areas, the ilium, ischium, and pubis
hip joint
joint located at the proximal end of the lower limb; formed by the articulation between the acetabulum of the hip bone and the head of the femur
hippocampus
gray matter deep in the temporal lobe that is very important for long-term memory formation
histamine
vasoactive mediator in granules of mast cells released in response to injury that causes vasodilation, endothelium permeability, and is the primary cause of allergies and anaphylactic shock
histology
microscopic study of tissue architecture, organization, and function
histone
family of proteins that associate with DNA in the nucleus to form chromatin
hole
opening or depression in a bone
holocrine secretion
release of a substance caused by the rupture of a gland cell, which becomes part of the secretion
homeostasis
steady state of body systems that living organisms maintain
homologous
describes two copies of the same chromosome (not identical), one inherited from each parent
homozygous
having two identical alleles for a given gene
hook of the hamate bone
bony extension located on the anterior side of the hamate carpal bone
horizontal plate
medial extension from the palatine bone that forms the posterior quarter of the hard palate
hormone
secretion of an endocrine organ that travels via the bloodstream or lymphatics to induce a response in target cells or tissues in another part of the body
hormone receptor
protein within a cell or on the cell membrane that binds a hormone, initiating the target cell response
human chorionic gonadotropin (hCG)
hormone that directs the corpus luteum to survive, enlarge, and continue producing progesterone and estrogen to suppress menses and secure an environment suitable for the developing embryo
humeroradial joint
articulation between the capitulum of the humerus and head of the radius
humeroulnar joint
articulation between the trochlea of humerus and the trochlear notch of the ulna; uniaxial hinge joint that allows for flexion/extension of the forearm
humerus
single bone of the upper arm
hyaline cartilage
most common type of cartilage, smooth and made of short collagen fibers embedded in a chondroitin sulfate ground substance
hydrochloric acid (HCl)
digestive acid secreted by parietal cells in the stomach
hydrogen bond
dipole-dipole bond in which a hydrogen atom covalently bonded to an electronegative atom is weakly attracted to a second electronegative atom
hydrophilic
describes a substance or structure attracted to water
hydrophobic
describes a substance or structure repelled by water
hydrostatic pressure
pressure exerted by a fluid against a wall, caused by its own weight or pumping force
hydroxymethylglutaryl CoA (HMG CoA)
molecule created in the first step of the creation of ketone bodies from acetyl CoA
hymen
membrane that covers part of the opening of the vagina
hyoglossus
muscle that originates on the hyoid bone to move the tongue downward and flatten it
hyoid bone
small, U-shaped bone located in upper neck that does not contact any other bone
hypercalcemia
condition characterized by abnormally high levels of calcium
hypercapnia
abnormally elevated blood levels of CO2
hyperchloremia
higher-than-normal blood chloride levels
hyperextension
excessive extension of joint, beyond the normal range of movement
hyperflexia
overly flexed joints
hyperflexion
excessive flexion of joint, beyond the normal range of movement
hyperglycemia
abnormally high blood glucose levels
Hyperkalemia
higher-than-normal blood potassium levels
hypernatremia
abnormal increase in blood sodium levels
hyperparathyroidism
disorder caused by overproduction of PTH that results in abnormally elevated blood calcium
hyperphosphatemia
abnormally increased blood phosphate levels
hyperplasia
process in which one cell splits to produce new cells
hyperpnea
increased rate and depth of ventilation due to an increase in oxygen demand that does not significantly alter blood oxygen or carbon dioxide levels
hypertension
chronic and persistent blood pressure measurements of 140/90 mm Hg or above
hyperthyroidism
clinically abnormal, elevated level of thyroid hormone in the blood; characterized by an increased metabolic rate, excess body heat, sweating, diarrhea, weight loss, and increased heart rate
hypertonia
abnormally high muscle tone
hypertonic
describes a solution concentration that is higher than a reference concentration
hypertrophic cardiomyopathy
pathological enlargement of the heart, generally for no known reason
hypertrophy
addition of structural proteins to muscle fibers
hyperventilation
increased ventilation rate that leads to abnormally low blood carbon dioxide levels and high (alkaline) blood pH
hypervolemia
abnormally high levels of fluid and blood within the body
hypoblast
lower layer of cells of the embryonic disc that extend into the blastocoel to form the yolk sac
hypocalcemia
condition characterized by abnormally low levels of calcium
Hypocapnia
abnormally low blood levels of CO2
hypochloremia
lower-than-normal blood chloride levels
hypodermis
connective tissue connecting the integument to the underlying bone and muscle
hypoglossal nerve
twelfth cranial nerve; responsible for contraction of muscles of the tongue
Hypokalemia
abnormally decreased blood levels of potassium
hyponatremia
lower-than-normal levels of sodium in the blood
hyponychium
thickened layer of stratum corneum that lies below the free edge of the nail
hypoparathyroidism
disorder caused by underproduction of PTH that results in abnormally low blood calcium
hypophosphatemia
abnormally low blood phosphate levels
hypophyseal (pituitary) fossa
shallow depression on top of the sella turcica that houses the pituitary (hypophyseal) gland
hypophyseal portal system
network of blood vessels that enables hypothalamic hormones to travel into the anterior lobe of the pituitary without entering the systemic circulation
hypothalamus
major region of the diencephalon inferior to the thalamus and responsible for coordinating autonomic and endocrine control of homeostasis
hypothenar
group of muscles on the medial aspect of the palm
hypothenar eminence
rounded contour of muscle at the base of the little finger
hypothyroidism
clinically abnormal, low level of thyroid hormone in the blood; characterized by low metabolic rate, weight gain, cold extremities, constipation, and reduced mental activity
hypotonia
abnormally low muscle tone caused by the absence of low-level contractions
hypotonic
describes a solution concentration that is lower than a reference concentration
hypotonicity
low muscle tone, a sign of LMN disease
hypovolemia
abnormally low levels of fluid and blood within the body
hypovolemic shock
type of circulatory shock caused by excessive loss of blood volume due to hemorrhage or possibly dehydration
hypoxemia
below-normal level of oxygen saturation of blood (typically <95 percent)
hypoxia
lack of oxygen supply to the tissues

I

IgA
antibody whose dimer is secreted by exocrine glands, is especially effective against digestive and respiratory pathogens, and can pass immunity to an infant through breastfeeding
IgD
class of antibody whose only known function is as a receptor on naive B cells; important in B cell activation
IgE
antibody that binds to mast cells and causes antigen-specific degranulation during an allergic response
IgG
main blood antibody of late primary and early secondary responses; passed from mother to unborn child via placenta
IgM
antibody whose monomer is a surface receptor of naive B cells; the pentamer is the first antibody made blood plasma during primary responses
ileocecal sphincter
sphincter located where the small intestine joins with the large intestine
ileum
end of the small intestine between the jejunum and the large intestine
iliac crest
curved, superior margin of the ilium
iliac fossa
shallow depression found on the anterior and medial surfaces of the upper ilium
iliacus
muscle that, along with the psoas major, makes up the iliopsoas
iliococcygeus
muscle that makes up the levator ani along with the pubococcygeus
iliocostalis cervicis
muscle of the iliocostalis group associated with the cervical region
iliocostalis group
laterally placed muscles of the erector spinae
iliocostalis lumborum
muscle of the iliocostalis group associated with the lumbar region
iliocostalis thoracis
muscle of the iliocostalis group associated with the thoracic region
iliofemoral ligament
intrinsic ligament spanning from the ilium of the hip bone to the femur, on the superior-anterior aspect of the hip joint
iliopsoas group
muscle group consisting of iliacus and psoas major muscles, that flexes the thigh at the hip, rotates it laterally, and flexes the trunk of the body onto the hip
iliotibial tract
muscle that inserts onto the tibia; made up of the gluteus maximus and connective tissues of the tensor fasciae latae
ilium
superior portion of the hip bone
immediate hypersensitivity
(type I) IgE-mediated mast cell degranulation caused by crosslinking of surface IgE by antigen
immune system
series of barriers, cells, and soluble mediators that combine to response to infections of the body with pathogenic organisms
immunoglobulin
protein antibody; occurs as one of five main classes
immunoglobulins
(also, antibodies or gamma globulins) antigen-specific proteins produced by specialized B lymphocytes that protect the body by binding to foreign objects such as bacteria and viruses
immunological memory
ability of the adaptive immune response to mount a stronger and faster immune response upon re-exposure to a pathogen
implantation
process by which a blastocyst embeds itself in the uterine endometrium
inactivation gate
part of a voltage-gated Na+ channel that closes when the membrane potential reaches +30 mV
inactive proenzymes
forms in which proteases are stored and released to prevent the inappropriate digestion of the native proteins of the stomach, pancreas, and small intestine
incisor
midline, chisel-shaped tooth used for cutting into food
incomplete dominance
pattern of inheritance in which a heterozygous genotype expresses a phenotype intermediate between dominant and recessive phenotypes
incus
(also, anvil) ossicle of the middle ear that connects the malleus to the stapes
indirect pathway
connections within the basal nuclei from the striatum through the globus pallidus external segment and subthalamic nucleus to the globus pallidus internal segment/substantia nigra pars compacta that result in inhibition of the thalamus to decrease cortical control of movement
Inferior
describes a position below or lower than another part of the body proper; near or toward the tail (in humans, the coccyx, or lowest part of the spinal column); also referred to as caudal
inferior angle of the scapula
inferior corner of the scapula located where the medial and lateral borders meet
inferior articular process
bony process that extends downward from the vertebral arch of a vertebra that articulates with the superior articular process of the next lower vertebra
inferior cerebellar peduncle (ICP)
input to the cerebellum, largely from the inferior olive, that represents sensory feedback from the periphery
inferior colliculus
last structure in the auditory brainstem pathway that projects to the thalamus and superior colliculus
inferior extensor retinaculum
cruciate ligament of the ankle
inferior gemellus
muscle deep to the gluteus maximus on the lateral surface of the thigh that laterally rotates the femur at the hip
inferior mesenteric artery
branch of the abdominal aorta; supplies blood to the distal segment of the large intestine and rectum
inferior mesenteric ganglion
one of the collateral ganglia of the sympathetic system that projects to the digestive system
inferior nasal concha
one of the paired bones that project from the lateral walls of the nasal cavity to form the largest and most inferior of the nasal conchae
inferior oblique
extraocular muscle responsible for lateral rotation of the eye
inferior olive
nucleus in the medulla that is involved in processing information related to motor control
inferior phrenic artery
branch of the abdominal aorta; supplies blood to the inferior surface of the diaphragm
inferior pubic ramus
narrow segment of bone that passes inferiorly and laterally from the pubic body; joins with the ischial ramus to form the ischiopubic ramus
inferior rectus
extraocular muscle responsible for looking down
inferior rotation
movement of the scapula during upper limb adduction in which the glenoid cavity of the scapula moves in a downward direction as the medial end of the scapular spine moves in an upward direction
inferior vena cava
large systemic vein that returns blood to the heart from areas inferior to the diaphragm
inflammation
basic innate immune response of tissue to injury, characterized by heat, redness, pain, and swelling
infraglenoid tubercle
small bump or roughened area located on the lateral border of the scapula, near the inferior margin of the glenoid cavity
infrahyoid muscles
anterior neck muscles that are attached to, and inferior to the hyoid bone
infraorbital foramen
opening located on anterior skull, below the orbit
infraspinatus
muscle that laterally rotates the arm
infraspinous fossa
broad depression located on the posterior scapula, inferior to the spine
infundibulum of the brain
stalk containing vasculature and neural tissue that connects the pituitary gland to the hypothalamus (also called the pituitary stalk)
infundibulum of the uterine tube
wide, distal portion of the uterine tube terminating in fimbriae
ingestion
taking food into the GI tract through the mouth
inguinal canal
opening in abdominal wall that connects the testes to the abdominal cavity
inhibin
hormone secreted by the male and female gonads that inhibits FSH production by the anterior pituitary
inhibitory postsynaptic potential (IPSP)
graded potential in the postsynaptic membrane that is the result of hyperpolarization and makes an action potential less likely to occur
initial segment
first part of axon where the electrical signals known as action potentials are generated.
innate immune response
rapid but relatively nonspecific immune response
inner cell mass
cluster of cells within the blastocyst that is fated to become the embryo
inner ear
structure within the temporal bone that contains the sensory apparati of hearing and balance
inner segment
in the eye, the section of a photoreceptor that contains the nucleus and other major organelles for normal cellular functions
inner synaptic layer
layer in the retina where bipolar cells connect to RGCs
innermost intercostal
the deepest intercostal muscles that draw the ribs together
inorganic compound
substance that does not contain both carbon and hydrogen
inositol triphosphate (IP3)
molecule that initiates the release of calcium ions from intracellular stores
insertion
end of a skeletal muscle that is attached to the structure (usually a bone) that is moved when the muscle contracts
inspiration
(also, inhalation) process that causes air to enter the lungs
Inspiratory capacity (IC)
sum of the TV and IRV, which is the amount of air that can maximally be inhaled past a tidal expiration
inspiratory reserve volume (IRV)
amount of air that enters the lungs due to deep inhalation past the tidal volume
insulin
hormone secreted by the pancreas that stimulates the cellular uptake and utilization of glucose, thereby decreasing blood glucose levels
insulin-like growth factors (IGF)
protein that enhances cellular proliferation, inhibits apoptosis, and stimulates the cellular uptake of amino acids for protein synthesis
integral protein
membrane-associated protein that spans the entire width of the lipid bilayer
integration
nervous system function that processes sensory perceptions and produce a response
integration center
the site of communication between sensory and motor neurons
integumentary system
skin and its accessory structures
interatrial band
(also, Bachmann’s bundle) group of specialized conducting cells that transmit the impulse directly from the SA node in the right atrium to the left atrium
interatrial septum
cardiac septum located between the two atria; contains the fossa ovalis after birth
interaural intensity difference
cue used to aid sound localization in the horizontal plane that compares the relative loudness of sounds at the two ears, because the ear closer to the sound source will hear a slightly more intense sound
interaural time difference
cue used to help with sound localization in the horizontal plane that compares the relative time of arrival of sounds at the two ears, because the ear closer to the sound source will receive the stimulus microseconds before the other ear
intercalated cell
specialized cell of the collecting ducts that secrete or absorb acid or bicarbonate; important in acid–base balance
intercalated disc
physical junction between adjacent cardiac muscle cells; consisting of desmosomes, specialized linking proteoglycans, and gap junctions that allow passage of ions between the two cells
intercondylar eminence
irregular elevation on the superior end of the tibia, between the articulating surfaces of the medial and lateral condyles
intercondylar fossa
deep depression on the posterior side of the distal femur that separates the medial and lateral condyles
intercostal artery
branch of the thoracic aorta; supplies blood to the muscles of the thoracic cavity and vertebral column
intercostal muscles
muscles that span the spaces between the ribs
intercostal nerve
systemic nerve in the thoracic cavity that is found between two ribs
intercostal vein
drains the muscles of the thoracic wall and leads to the azygos vein
interferons
early induced proteins made in virally infected cells that cause nearby cells to make antiviral proteins
interleukins
signaling molecules that may function in hemopoiesis, inflammation, and specific immune responses
intermediate
group of midpalmar muscles
intermediate cuneiform
middle of the three cuneiform tarsal bones; articulates posteriorly with the navicular bone, medially with the medial cuneiform bone, laterally with the lateral cuneiform bone, and anteriorly with the second metatarsal bone
intermediate filament
type of cytoskeletal filament made of keratin, characterized by an intermediate thickness, and playing a role in resisting cellular tension
internal acoustic meatus
opening into petrous ridge, located on the lateral wall of the posterior cranial fossa
internal anal sphincter
involuntary smooth muscle sphincter in the anal canal
internal callus
fibrocartilaginous matrix, in the endosteal region, between the two ends of a broken bone
internal capsule
segment of the descending motor pathway that passes between the caudate nucleus and the putamen
internal carotid artery
branch from the common carotid artery that enters the cranium and supplies blood to the brain
internal elastic membrane
membrane composed of elastic fibers that separates the tunica intima from the tunica media; seen in larger arteries
internal iliac artery
branch from the common iliac arteries; supplies blood to the urinary bladder, walls of the pelvis, external genitalia, and the medial portion of the femoral region; in females, also provide blood to the uterus and vagina
internal iliac vein
drains the pelvic organs and integument; formed from several smaller veins in the region; leads to the common iliac vein
internal intercostal
muscles the intermediate intercostal muscles that draw the ribs together
internal jugular vein
one of a pair of major veins located in the neck region that passes through the jugular foramen and canal, flows parallel to the common carotid artery that is more or less its counterpart; primarily drains blood from the brain, receives the superficial facial vein, and empties into the subclavian vein
internal oblique
flat, intermediate abdominal muscle with fascicles that run perpendicular to those of the external oblique
internal respiration
gas exchange that occurs at the level of body tissues
internal root sheath
innermost layer of keratinocytes in the hair follicle that surround the hair root up to the hair shaft
internal thoracic artery
(also, mammary artery) arises from the subclavian artery; supplies blood to the thymus, pericardium of the heart, and the anterior chest wall
internal thoracic vein
(also, mammary artery) arises from the subclavian artery; supplies blood to the thymus, pericardium of the heart, and the anterior chest wall
internal urinary sphincter
smooth muscle at the juncture of the bladder and urethra; relaxes as the bladder fills to allow urine into the urethra
internodal pathways
specialized conductile cells within the atria that transmit the impulse from the SA node throughout the myocardial cells of the atrium and to the AV node
internuclear ophthalmoplegia
deficit of conjugate lateral gaze because the lateral rectus muscle of one eye does not contract resulting from damage to the abducens nerve or the MLF
interoceptor
sensory receptor that is positioned to interpret stimuli from internal organs, such as stretch receptors in the wall of blood vessels
interosseous border of the fibula
small ridge running down the medial side of the fibular shaft; for attachment of the interosseous membrane between the fibula and tibia
interosseous border of the radius
narrow ridge located on the medial side of the radial shaft; for attachment of the interosseous membrane between the ulna and radius bones
interosseous border of the tibia
small ridge running down the lateral side of the tibial shaft; for attachment of the interosseous membrane between the tibia and fibula
interosseous border of the ulna
narrow ridge located on the lateral side of the ulnar shaft; for attachment of the interosseous membrane between the ulna and radius
interosseous membrane
wide sheet of fibrous connective tissue that fills the gap between two parallel bones, forming a syndesmosis; found between the radius and ulna of the forearm and between the tibia and fibula of the leg
interosseous membrane of the forearm
sheet of dense connective tissue that unites the radius and ulna bones
interosseous membrane of the leg
sheet of dense connective tissue that unites the shafts of the tibia and fibula bones
interphalangeal joint
articulation between adjacent phalanx bones of the hand or foot digits
interphase
entire life cycle of a cell, excluding mitosis
interstitial fluid (IF)
fluid in the small spaces between cells not contained within blood vessels
interstitial fluid colloidal osmotic pressure (IFCOP)
pressure exerted by the colloids within the interstitial fluid
interstitial fluid hydrostatic pressure (IFHP)
force exerted by the fluid in the tissue spaces
interstitial growth
growth by adding within the interior of a structure, occurs by hyaline cartilage at epiphyseal plate
intertrochanteric crest
short, prominent ridge running between the greater and lesser trochanters on the posterior side of the proximal femur
intertrochanteric line
small ridge running between the greater and lesser trochanters on the anterior side of the proximal femur
intertubercular groove (sulcus)
bicipital groove; narrow groove located between the greater and lesser tubercles of the humerus
interventricular foramina
openings between the lateral ventricles and third ventricle allowing for the passage of CSF
interventricular septum
cardiac septum located between the two ventricles
intervertebral disc
structure located between the bodies of adjacent vertebrae that strongly joins the vertebrae; provides padding, weight bearing ability, and enables vertebral column movements
intervertebral foramen
opening located between adjacent vertebrae for exit of a spinal nerve
intestinal gland
(also, crypt of Lieberkühn) gland in the small intestinal mucosa that secretes intestinal juice
intestinal juice
mixture of water and mucus that helps absorb nutrients from chyme
intestinal phase
phase of gastric secretion that begins when chyme enters the intestine
intorsion
medial rotation of the eye around its axis
intra-alveolar pressure
(intrapulmonary pressure) pressure of the air within the alveoli
intracapsular ligament
ligament that is located within the articular capsule of a synovial joint
intracellular fluid (ICF)
fluid in the cytosol of cells
intramembranous ossification
process by which bone forms directly from mesenchymal tissue
intramural ganglia
terminal ganglia of the parasympathetic system that are found within the walls of the target effector
intrapleural pressure
pressure within the pleural cavity due to the fluid bond between the visceral and parietal pleura and the parietal pleura’s adhesion to the body wall and diaphragm
intrinsic factor
glycoprotein required for vitamin B12 absorption in the small intestine
intrinsic ligament
ligament that is fused to or incorporated into the wall of the articular capsule of a synovial joint
intrinsic muscles of the hand
muscles that move the wrists, hands, and fingers and originate in the palm
intrinsic muscles of the tongue
muscles that originate out of, and insert into, other tissues within the tongue and control the shape of the tongue
intrinsic pathway
initial coagulation pathway that begins with vascular damage or contact with foreign substances, and results in the activation of the common pathway
intron
non-coding regions of a pre-mRNA transcript that may be removed during splicing
inversion
foot movement involving the intertarsal joints of the foot in which the bottom of the foot is turned toward the midline
involution
postpartum shrinkage of the uterus back to its pre-pregnancy volume
ion
atom with an overall positive or negative charge
ionic bond
attraction between an anion and a cation
Ionotropic receptors
neurotransmitter receptor that acts as an ion channel gate, and opens by the binding of the neurotransmitter
ipsilateral
word meaning on the same side, as in axons that do not cross the midline in a fiber tract
iris
colored portion of the anterior eye that surrounds the pupil
irregular bone
bone of complex shape; protects internal organs from compressive forces
ischemia
insufficient blood flow to the tissues
ischemic stroke
disruption of blood flow to the brain because blood cannot flow through blood vessels as a result of a blockage or narrowing of the vessel
ischial ramus
bony extension projecting anteriorly and superiorly from the ischial tuberosity; joins with the inferior pubic ramus to form the ischiopubic ramus
ischial spine
pointed, bony projection from the posterior margin of the ischium that separates the greater sciatic notch and lesser sciatic notch
ischial tuberosity
large, roughened protuberance that forms the posteroinferior portion of the hip bone; weight-bearing region of the pelvis when sitting
ischiococcygeus
muscle that assists the levator ani and pulls the coccyx anteriorly
ischiofemoral ligament
intrinsic ligament spanning from the ischium of the hip bone to the femur, on the posterior aspect of the hip joint
ischiopubic ramus
narrow extension of bone that connects the ischial tuberosity to the pubic body; formed by the junction of the ischial ramus and inferior pubic ramus
ischium
posteroinferior portion of the hip bone
isometric contraction
muscle contraction that occurs with no change in muscle length
isotonic
describes a solution concentration that is the same as a reference concentration
isotonic contraction
muscle contraction that involves changes in muscle length
isotope
one of the variations of an element in which the number of neutrons differ from each other
isovolumic contraction
(also, isovolumetric contraction) initial phase of ventricular contraction in which tension and pressure in the ventricle increase, but no blood is pumped or ejected from the heart
isovolumic ventricular relaxation phase
initial phase of the ventricular diastole when pressure in the ventricles drops below pressure in the two major arteries, the pulmonary trunk, and the aorta, and blood attempts to flow back into the ventricles, producing the dicrotic notch of the ECG and closing the two semilunar valves
isthmus
narrow, medial portion of the uterine tube that joins the uterus

J

jaw-jerk reflex
stretch reflex of the masseter muscle
jejunum
middle part of the small intestine between the duodenum and the ileum
joint
site at which two or more bones or bone and cartilage come together (articulate)
joint cavity
space enclosed by the articular capsule of a synovial joint that is filled with synovial fluid and contains the articulating surfaces of the adjacent bones
joint interzone
site within a growing embryonic limb bud that will become a synovial joint
jugular (suprasternal) notch
shallow notch located on superior surface of sternal manubrium
jugular foramen
irregularly shaped opening located in the lateral floor of the posterior cranial cavity
jugular veins
blood vessels that return “used” blood from the head and neck
junctional rhythm
the electrical impulse of the heart originates at the AV node, rather than the SA node
juxtaglomerular apparatus (JGA)
located at the juncture of the DCT and the afferent and efferent arterioles of the glomerulus; plays a role in the regulation of renal blood flow and GFR
juxtaglomerular cell
modified smooth muscle cells of the afferent arteriole; secretes renin in response to a drop in blood pressure
juxtamedullary nephrons
nephrons adjacent to the border of the cortex and medulla with loops of Henle that extend into the renal medulla

K

karyotype
systematic arrangement of images of chromosomes into homologous pairs
keloid
type of scar that has layers raised above the skin surface
keratin
type of structural protein that gives skin, hair, and nails its hard, water-resistant properties
keratinocyte
cell that produces keratin and is the most predominant type of cell found in the epidermis
keratohyalin
granulated protein found in the stratum granulosum
ketone bodies
alternative source of energy when glucose is limited, created when too much acetyl CoA is created during fatty acid oxidation
kinesthesia
general sensory perception of movement of the body
kinetic energy
energy that matter possesses because of its motion
kinetochore
region of a centromere where microtubules attach to a pair of sister chromatids
knee joint
joint that separates the thigh and leg portions of the lower limb; formed by the articulations between the medial and lateral condyles of the femur, and the medial and lateral condyles of the tibia
Korotkoff sounds
noises created by turbulent blood flow through the vessels
Krebs cycle
also called the citric acid cycle or the tricarboxylic acid cycle, converts pyruvate into CO2 and high-energy FADH2, NADH, and ATP molecules
kyphosis
(also, humpback or hunchback) excessive posterior curvature of the thoracic vertebral column region

L

labia majora
hair-covered folds of skin located behind the mons pubis
labia minora
thin, pigmented, hairless flaps of skin located medial and deep to the labia majora
labial frenulum
midline mucous membrane fold that attaches the inner surface of the lips to the gums
labium
lip
lacrimal bone
paired bones that contribute to the anterior-medial wall of each orbit
lacrimal duct
duct in the medial corner of the orbit that drains tears into the nasal cavity
lacrimal fossa
shallow depression in the anterior-medial wall of the orbit, formed by the lacrimal bone that gives rise to the nasolacrimal canal
lacrimal gland
gland lateral to the orbit that produces tears to wash across the surface of the eye
lactase
brush border enzyme that breaks down lactose into glucose and galactose
lactate
product of anaerobic glycolysis
lactation
process by which milk is synthesized and secreted from the mammary glands of the postpartum female breast in response to sucking at the nipple
lacteal
lymphatic capillary in the villi
lactiferous ducts
ducts that connect the mammary glands to the nipple and allow for the transport of milk
lactiferous sinus
area of milk collection between alveoli and lactiferous duct
lacunae
(singular = lacuna) small spaces in bone or cartilage tissue that cells occupy
lacunae (of the bones)
(singular = lacuna) spaces in a bone that house an osteocyte
lambdoid suture
inverted V-shaped joint that unites the occipital bone to the right and left parietal bones on the posterior skull
lamina
portion of the vertebral arch on each vertebra that extends between the transverse and spinous process
lamina propria
areolar connective tissue underlying a mucous membrane
Langerhans cell
specialized dendritic cell found in the stratum spinosum that functions as a macrophage
lanugo
silk-like hairs that coat the fetus; shed later in fetal development
large intestine
terminal portion of the alimentary canal
laryngeal prominence
region where the two lamina of the thyroid cartilage join, forming a protrusion known as “Adam’s apple”
laryngopharynx
region of the pharynx bordered by the oropharynx and esophagus and trachea that serves as a route for both air and food
laryngotracheal
bud forms from the lung bud, has a tracheal end and bulbous bronchial buds at the distal end
larynx
cartilaginous structure that produces the voice, prevents food and beverages from entering the trachea, and regulates the volume of air that enters and leaves the lungs
latch-bridges
subset of a cross-bridge in which actin and myosin remain locked together
latent period
the time when a twitch does not produce contraction
lateral
describes the side or direction toward the side of the body
lateral (external) rotation
movement of the arm at the shoulder joint or the thigh at the hip joint that moves the anterior surface of the limb away from the midline of the body
lateral apertures
pair of openings from the fourth ventricle to the subarachnoid space on either side and between the medulla and cerebellum
lateral border of the scapula
diagonally oriented lateral margin of the scapula
lateral circumflex artery
branch of the deep femoral artery; supplies blood to the deep muscles of the thigh and the ventral and lateral regions of the integument
lateral column
white matter of the spinal cord between the posterior horn on one side and the axons from the anterior horn on the same side; composed of many different groups of axons, of both ascending and descending tracts, carrying motor commands to and from the brain
lateral compartment of the leg
region that includes the fibularis (peroneus) longus and the fibularis (peroneus) brevis and their associated blood vessels and nerves
lateral condyle of the femur
smooth, articulating surface that forms the distal and posterior sides of the lateral expansion of the distal femur
lateral condyle of the tibia
lateral, expanded region of the proximal tibia that includes the smooth surface that articulates with the lateral condyle of the femur as part of the knee joint
lateral corticospinal tract
division of the corticospinal pathway that travels through the lateral column of the spinal cord and controls appendicular musculature through the lateral motor neurons in the ventral (anterior) horn
lateral cuneiform
most lateral of the three cuneiform tarsal bones; articulates posteriorly with the navicular bone, medially with the intermediate cuneiform bone, laterally with the cuboid bone, and anteriorly with the third metatarsal bone
lateral epicondyle of the femur
roughened area of the femur located on the lateral side of the lateral condyle
lateral epicondyle of the humerus
small projection located on the lateral side of the distal humerus
lateral excursion
side-to-side movement of the mandible away from the midline, toward either the right or left side
lateral flexion
bending of the neck or body toward the right or left side
lateral geniculate nucleus
thalamic target of the RGCs that projects to the visual cortex
lateral horn
region of the spinal cord gray matter in the thoracic, upper lumbar, and sacral regions that is the central component of the sympathetic division of the autonomic nervous system
lateral malleolus
expanded distal end of the fibula
lateral meniscus
C-shaped fibrocartilage articular disc located at the knee, between the lateral condyle of the femur and the lateral condyle of the tibia
lateral plantar artery
arises from the bifurcation of the posterior tibial arteries; supplies blood to the lateral plantar surfaces of the foot
lateral pterygoid
muscle that moves the mandible from side to side
lateral pterygoid plate
paired, flattened bony projections of the sphenoid bone located on the inferior skull, lateral to the medial pterygoid plate
lateral rectus
extraocular muscle responsible for abduction of the eye
lateral sacral crest
paired irregular ridges running down the lateral sides of the posterior sacrum that was formed by the fusion of the transverse processes from the five sacral vertebrae
lateral sulcus
surface landmark of the cerebral cortex that marks the boundary between the temporal lobe and the frontal and parietal lobes
lateral supracondylar ridge
narrow, bony ridge located along the lateral side of the distal humerus, superior to the lateral epicondyle
lateral tibiofemoral joint
portion of the knee consisting of the articulation between the lateral condyle of the tibia and the lateral condyle of the femur; allows for flexion/extension at the knee
lateral ventricles
portions of the ventricular system that are in the region of the cerebrum
lateralis
to the outside
latissimus dorsi
broad, triangular axial muscle located on the inferior part of the back
leakage channel
ion channel that opens randomly and is not gated to a specific event, also known as a non-gated channel
leaky tight junctions
tight junctions in which the sealing strands of proteins between the membranes of adjacent cells are fewer in number and incomplete; allows limited intercellular movement of solvent and solutes
left atrioventricular valve
(also, mitral valve or bicuspid valve) valve located between the left atrium and ventricle; consists of two flaps of tissue
left colic flexure
(also, splenic flexure) point where the transverse colon curves below the inferior end of the spleen
left gastric artery
branch of the celiac trunk; supplies blood to the stomach
leg
portion of the lower limb located between the knee and ankle joints
lens
component of the eye that focuses light on the retina
leptin
protein hormone secreted by adipose tissues in response to food consumption that promotes satiety
lesser pelvis
(also, lesser pelvic cavity or true pelvis) narrow space located within the pelvis, defined superiorly by the pelvic brim (pelvic inlet) and inferiorly by the pelvic outlet
lesser sciatic foramen
pelvic opening formed by the lesser sciatic notch of the hip bone, the sacrospinous ligament, and the sacrotuberous ligament
lesser sciatic notch
shallow indentation along the posterior margin of the ischium, inferior to the ischial spine
lesser splanchnic nerve
nerve that contains fibers of the central sympathetic neurons that do not synapse in the chain ganglia but project onto the inferior mesenteric ganglion
lesser trochanter
small, bony projection on the medial side of the proximal femur, at the base of the femoral neck
lesser tubercle
small, bony prominence located on anterior side of the proximal humerus
lesser wings of the sphenoid bone
lateral extensions of the sphenoid bone that form the bony lip separating the anterior and middle cranial fossae
let-down reflex
release of milk from the alveoli triggered by infant suckling
leukemia
cancer involving leukocytes
leukocyte
(also, white blood cell) colorless, nucleated blood cell, the chief function of which is to protect the body from disease
leukocytosis
excessive leukocyte proliferation
leukopenia
below-normal production of leukocytes
levator ani
pelvic muscle that resists intra-abdominal pressure and supports the pelvic viscera
levator palpebrae superioris
muscle that causes elevation of the upper eyelid, controlled by fibers in the oculomotor nerve
lever arm
a rigid bar, like a bone
Leydig cells
cells between the seminiferous tubules of the testes that produce testosterone; a type of interstitial cell
ligament
a strong band of dense connective tissue that connects one bone to another bone
ligament of the head of the femur
intracapsular ligament that runs from the acetabulum of the hip bone to the fovea capitis of the femural head
ligamentum flavum
series of short ligaments that unite the lamina of adjacent vertebrae
ligand-gated cation channel
ion channel, such as the nicotinic receptor, that is specific to positively charged ions and opens when a molecule such as a neurotransmitter binds to it
ligand-gated channel
another name for an ionotropic receptor for which a neurotransmitter is the ligand
light chain
small protein chain of an antibody
lightening
descent of the fetus lower into the pelvis in late pregnancy; also called “dropping”
limb bud
small elevation that appears on the lateral side of the embryo during the fourth or fifth week of development, which gives rise to an upper or lower limb
limbic cortex
collection of structures of the cerebral cortex that are involved in emotion, memory, and behavior and are part of the larger limbic system
limbic lobe
structures arranged around the edges of the cerebrum that are involved in memory and emotion
limbic system
structures at the edge (limit) of the boundary between the forebrain and hindbrain that are most associated with emotional behavior and memory formation
linea alba
white, fibrous band that runs along the midline of the trunk
linea aspera
longitudinally running bony ridge located in the middle third of the posterior femur
lingual frenulum
mucous membrane fold that attaches the bottom of the tongue to the floor of the mouth
lingual lipase
digestive enzyme from glands in the tongue that acts on triglycerides
lingual tonsil
lymphoid tissue located at the base of the tongue
lingula
small flap of bone located on the inner (medial) surface of mandibular ramus, next to the mandibular foramen
lipid
class of nonpolar organic compounds built from hydrocarbons and distinguished by the fact that they are not soluble in water
lipogenesis
synthesis of lipids that occurs in the liver or adipose tissues
lipolysis
breakdown of triglycerides into glycerol and fatty acids
lipoprotein lipase
enzyme that breaks down triglycerides in chylomicrons into fatty acids and monoglycerides
liver
largest gland in the body whose main digestive function is the production of bile
load
the resistance to the force, due to gravity or the mass of an object
load arm
the distance between the fulcrum (joint) and the load (center of mass)
lochia
postpartum vaginal discharge that begins as blood and ends as a whitish discharge; the end of lochia signals that the site of placental attachment has healed
long bone
cylinder-shaped bone that is longer than it is wide; functions as a lever
long reflex
reflex arc that includes the central nervous system
longissimus capitis
muscle of the longissimus group associated with the head region
longissimus cervicis
muscle of the longissimus group associated with the cervical region
longissimus group
intermediately placed muscles of the erector spinae
longissimus thoracis
muscle of the longissimus group associated with the thoracic region
longitudinal fissure
large separation along the midline between the two cerebral hemispheres
longus
long
loop of Henle
descending and ascending portions between the proximal and distal convoluted tubules; those of cortical nephrons do not extend into the medulla, whereas those of juxtamedullary nephrons do extend into the medulla
loose connective tissue
(also, areolar tissue) type of connective tissue proper that shows little specialization with cells dispersed in the matrix
lordosis
(also, swayback) excessive anterior curvature of the lumbar vertebral column region
lower esophageal sphincter
smooth muscle sphincter that regulates food movement from the esophagus to the stomach
lower motor neuron
second neuron in the motor command pathway that is directly connected to the skeletal muscle
lumbar arteries
branches of the abdominal aorta; supply blood to the lumbar region, the abdominal wall, and spinal cord
lumbar curvature
posteriorly concave curvature of the lumbar vertebral column region; a secondary curve of the vertebral column
lumbar enlargement
region of the ventral (anterior) horn of the spinal cord that has a larger population of motor neurons for the greater number of muscles of the lower limb
lumbar plexus
nerve plexus associated with the lumbar spinal nerves
lumbar puncture
procedure used to withdraw CSF from the lower lumbar region of the vertebral column that avoids the risk of damaging CNS tissue because the spinal cord ends at the upper lumbar vertebrae
lumbar veins
drain the lumbar portion of the abdominal wall and spinal cord; the superior lumbar veins drain into the azygos vein on the right or the hemiazygos vein on the left; blood from these vessels is returned to the superior vena cava rather than the inferior vena cava
lumbar vertebrae
five vertebrae numbered as L1–L5 that are located in lumbar region (lower back) of the vertebral column
lumbrical
muscle that flexes each finger at the metacarpophalangeal joints and extend each finger at the interphalangeal joints
lumen
interior of a tubular structure such as a blood vessel or a portion of the alimentary canal through which blood, chyme, or other substances travel
lunate
from the lateral side, the second of the four proximal carpal bones; articulates with the radius proximally, the capitate and hamate distally, the scaphoid laterally, and the triquetrum medially
lung
organ of the respiratory system that performs gas exchange
lung bud
median dome that forms from the endoderm of the foregut
lunula
basal part of the nail body that consists of a crescent-shaped layer of thick epithelium
luteinizing hormone (LH)
anterior pituitary hormone that triggers ovulation and the production of ovarian hormones in females, and the production of testosterone in males
lymph
fluid contained within the lymphatic system
lymph node
one of the bean-shaped organs found associated with the lymphatic vessels
lymphatic capillaries
smallest of the lymphatic vessels and the origin of lymph flow
lymphatic system
network of lymphatic vessels, lymph nodes, and ducts that carries lymph from the tissues and back to the bloodstream.
lymphatic trunks
large lymphatics that collect lymph from smaller lymphatic vessels and empties into the blood via lymphatic ducts
lymphocytes
agranular leukocytes of the lymphoid lineage characterized by a large nucleus and small rim of cytoplasm, many of which function in specific immunity
lymphoid nodules
unencapsulated patches of lymphoid tissue found throughout the body
lymphoid stem cells
type of hemopoietic stem cells that gives rise to lymphocytes, including various T cells, B cells, and NK cells, all of which function in immunity
lymphoma
form of cancer in which masses of malignant T and/or B lymphocytes collect in lymph nodes, the spleen, the liver, and other tissues
lysosome
membrane-bound cellular organelle originating from the Golgi apparatus and containing digestive enzymes
lysozyme
digestive enzyme with bactericidal properties

M

macromolecule
large molecule formed by covalent bonding
macrophage
ameboid phagocytic cell of the myeloid lineage found in several tissues throughout the body; a matured monocyte
macrophage oxidative metabolism
metabolism turned on in macrophages by T cell signals that help destroy intracellular bacteria
macula
enlargement at the base of a semicircular canal at which transduction of equilibrium stimuli takes place within the ampulla
macula densa
cells found in the part of the DCT forming the JGA; sense Na+ concentration in the forming urine
magnetic resonance imaging (MRI)
medical imaging technique in which a device generates a magnetic field to obtain detailed sectional images of the internal structures of the body
main pancreatic duct
(also, duct of Wirsung) duct through which pancreatic juice drains from the pancreas
major duodenal papilla
point at which the hepatopancreatic ampulla opens into the duodenum
major histocompatibility complex (MHC)
gene cluster whose proteins present antigens to T cells
malleus
(also, hammer) ossicle that is directly attached to the tympanic membrane
maltase
brush border enzyme that breaks down maltose and maltotriose into two and three molecules of glucose, respectively
mammary glands
glands inside the breast that secrete milk
mandible
unpaired bone that forms the lower jaw bone; the only moveable bone of the skull
mandibular foramen
opening located on the inner (medial) surface of the mandibular ramus
mandibular fossa
oval depression located on the inferior surface of the skull
mandibular notch
large U-shaped notch located between the condylar process and coronoid process of the mandible
manubrium
expanded, superior portion of the sternum
marginal arteries
branches of the right coronary artery that supply blood to the superficial portions of the right ventricle
mass movement
long, slow, peristaltic wave in the large intestine
mass number
sum of the number of protons and neutrons in the nucleus of an atom
masseter
main muscle for chewing that elevates the mandible to close the mouth
mast cell
cell found in the skin and the lining of body cells that contains cytoplasmic granules with vasoactive mediators such as histamine
mastication
chewing
mastoid process
large bony prominence on the inferior, lateral skull, just behind the earlobe
matter
physical substance; that which occupies space and has mass
maxillary bone
(also, maxilla) paired bones that form the upper jaw and anterior portion of the hard palate
maxillary sinus
air-filled space located with each maxillary bone; largest of the paranasal sinuses
maxillary vein
drains blood from the maxillary region and leads to the external jugular vein
maximus
largest
mean arterial pressure (MAP)
average driving force of blood to the tissues; approximated by taking diastolic pressure and adding 1/3 of pulse pressure
meatuses
one of three recesses (superior, middle, and inferior) in the nasal cavity attached to the conchae that increase the surface area of the nasal cavity
mechanical digestion
chewing, mixing, and segmentation that prepares food for chemical digestion
mechanically gated channel
ion channel that opens when a physical event directly affects the structure of the protein
mechanoreceptor
receptor cell that senses pain stimuli
meconium
fetal wastes consisting of ingested amniotic fluid, cellular debris, mucus, and bile
medial
describes the middle or direction toward the middle of the body
medial (internal) rotation
movement of the arm at the shoulder joint or the thigh at the hip joint that brings the anterior surface of the limb toward the midline of the body
medial border of the scapula
elongated, medial margin of the scapula
medial compartment of the thigh
a region that includes the adductor longus, adductor brevis, adductor magnus, pectineus, gracilis, and their associated blood vessels and nerves
medial condyle of the femur
smooth, articulating surface that forms the distal and posterior sides of the medial expansion of the distal femur
medial condyle of the tibia
medial, expanded region of the proximal tibia that includes the smooth surface that articulates with the medial condyle of the femur as part of the knee joint
medial cuneiform
most medial of the three cuneiform tarsal bones; articulates posteriorly with the navicular bone, laterally with the intermediate cuneiform bone, and anteriorly with the first and second metatarsal bones
medial epicondyle of the femur
roughened area of the distal femur located on the medial side of the medial condyle
medial epicondyle of the humerus
enlarged projection located on the medial side of the distal humerus
medial excursion
side-to-side movement that returns the mandible to the midline
medial forebrain bundle
fiber pathway that extends anteriorly into the basal forebrain, passes through the hypothalamus, and extends into the brain stem and spinal cord
medial geniculate nucleus
thalamic target of the auditory brain stem that projects to the auditory cortex
medial lemniscus
fiber tract of the dorsal column system that extends from the nuclei gracilis and cuneatus to the thalamus, and decussates
medial longitudinal fasciculus (MLF)
fiber pathway that connects structures involved in the control of eye and head position, from the superior colliculus to the vestibular nuclei and cerebellum
medial malleolus
bony expansion located on the medial side of the distal tibia
medial meniscus
C-shaped fibrocartilage articular disc located at the knee, between the medial condyle of the femur and medial condyle of the tibia
medial plantar artery
arises from the bifurcation of the posterior tibial arteries; supplies blood to the medial plantar surfaces of the foot
medial pterygoid
muscle that moves the mandible from side to side
medial pterygoid plate
paired, flattened bony projections of the sphenoid bone located on the inferior skull medial to the lateral pterygoid plate; form the posterior portion of the nasal cavity lateral wall
medial rectus
extraocular muscle responsible for adduction of the eye
medial tibiofemoral joint
portion of the knee consisting of the articulation between the medial condyle of the tibia and the medial condyle of the femur; allows for flexion/extension at the knee
medialis
to the inside
median antebrachial vein
vein that parallels the ulnar vein but is more medial in location; intertwines with the palmar venous arches
median aperture
singular opening from the fourth ventricle into the subarachnoid space at the midline between the medulla and cerebellum
median cubital vein
superficial vessel located in the antecubital region that links the cephalic vein to the basilic vein in the form of a v; a frequent site for a blood draw
median nerve
systemic nerve of the arm, located between the ulnar and radial nerves
median sacral artery
continuation of the aorta into the sacrum
median sacral crest
irregular ridge running down the midline of the posterior sacrum that was formed from the fusion of the spinous processes of the five sacral vertebrae
mediastinal artery
branch of the thoracic aorta; supplies blood to the mediastinum
medius
medium
medulla of hair
in hair, the innermost layer of keratinocytes originating from the hair matrix
medullary cavity
hollow region of the diaphysis; filled with yellow marrow
megakaryocyte
bone marrow cell that produces platelets
Meissner corpuscle
(also, tactile corpuscle) receptor in the skin that responds to light touch
melanin
pigment that determines the color of hair and skin
melanocyte
cell found in the stratum basale of the epidermis that produces the pigment melanin
melanoma
type of skin cancer that originates from the melanocytes of the skin
melanosome
intercellular vesicle that transfers melanin from melanocytes into keratinocytes of the epidermis
melatonin
amino acid–derived hormone that is secreted in response to low light and causes drowsiness
membrane potential
distribution of charge across the cell membrane, based on the charges of ions
memory cell
type of B or T lymphocyte that forms after exposure to a pathogen
memory T cells
long-lived immune cell reserved for future exposure to an pathogen
menarche
first menstruation in a pubertal female
meninges
protective outer coverings of the CNS composed of connective tissue
meniscus
articular disc
menses
shedding of the inner portion of the endometrium out though the vagina; also referred to as menstruation
menses phase
phase of the menstrual cycle in which the endometrial lining is shed
menstrual cycle
approximately 28-day cycle of changes in the uterus consisting of a menses phase, a proliferative phase, and a secretory phase
mental foramen
opening located on the anterior-lateral side of the mandibular body
mental protuberance
inferior margin of anterior mandible that forms the chin
Merkel cell
receptor cell in the stratum basale of the epidermis that responds to the sense of touch
merocrine secretion
release of a substance from a gland via exocytosis
mesangial
contractile cells found in the glomerulus; can contract or relax to regulate filtration rate
mesencephalic nucleus
component of the trigeminal nuclei that is found in the midbrain
mesencephalon
primary vesicle of the embryonic brain that does not significantly change through the rest of embryonic development and becomes the midbrain
mesenchymal cell
adult stem cell from which most connective tissue cells are derived
mesenchyme
embryonic tissue from which connective tissue cells derive
mesenteric plexus
nervous tissue within the wall of the digestive tract that contains neurons that are the targets of autonomic preganglionic fibers and that project to the smooth muscle and glandular tissues in the digestive organ
mesoappendix
mesentery of the appendix
mesoderm
the middle of three embryonic germ layers from which connective tissue, muscle tissue, and some epithelial tissue form
mesothelium
simple squamous epithelial portion of serous membranes, such as the superficial portion of the epicardium (the visceral pericardium) and the deepest portion of the pericardium (the parietal pericardium)
messenger RNA (mRNA)
nucleotide molecule that serves as an intermediate in the genetic code between DNA and protein
metabolic acidosis
condition wherein a deficiency of bicarbonate causes the blood to be overly acidic
metabolic alkalosis
condition wherein an excess of bicarbonate causes the blood to be overly alkaline
metabolic rate
amount of energy consumed minus the amount of energy expended by the body
metabolism
sum of all catabolic and anabolic reactions that take place in the body
metabotropic receptor
neurotransmitter receptor that involves a complex of proteins that cause metabolic changes in a cell
metacarpal bone
one of the five long bones that form the palm of the hand; numbered 1–5, starting on the lateral (thumb) side of the hand
metacarpophalangeal joint
articulation between the distal end of a metacarpal bone of the hand and a proximal phalanx bone of the thumb or a finger
metaphase
second stage of mitosis (and meiosis), characterized by the linear alignment of sister chromatids in the center of the cell
metaphase plate
linear alignment of sister chromatids in the center of the cell, which takes place during metaphase
metarteriole
short vessel arising from a terminal arteriole that branches to supply a capillary bed
metastasis
spread of cancer cells from a source to other parts of the body
metatarsal bone
one of the five elongated bones that forms the anterior half of the foot; numbered 1–5, starting on the medial side of the foot
metatarsophalangeal joint
articulation between a metatarsal bone of the foot and the proximal phalanx bone of a toe
metencephalon
secondary vesicle of the embryonic brain that develops into the pons and the cerebellum
MHC class I
found on most cells of the body, it binds to the CD8 molecule on T cells
MHC class II
found on macrophages, dendritic cells, and B cells, it binds to CD4 molecules on T cells
MHC polygeny
multiple MHC genes and their proteins found in body cells
MHC polymorphism
multiple alleles for each individual MHC locus
micelle
tiny lipid-transport compound composed of bile salts and phospholipids with a fatty acid and monoacylglyceride core
microcirculation
blood flow through the capillaries
microfilament
the thinnest of the cytoskeletal filaments; composed of actin subunits that function in muscle contraction and cellular structural support
microglia
glial cell type in the CNS that serves as the resident component of the immune system
microscopic anatomy
study of very small structures of the body using magnification
microscopy
study of very small structures of the body using magnification
microtubule
the thickest of the cytoskeletal filaments, composed of tubulin subunits that function in cellular movement and structural support
microvillus
small projection of the plasma membrane of the absorptive cells of the small intestinal mucosa
micturition
also called urination or voiding
midbrain
middle region of the adult brain that develops from the mesencephalon
midcarpal joint
articulation between the proximal and distal rows of the carpal bones; contributes to movements of the hand at the wrist
middle cardiac vein
vessel that parallels and drains the areas supplied by the posterior interventricular artery; drains into the great cardiac vein
middle cerebellar peduncle (MCP)
large, white-matter bridge from the pons that constitutes the major input to the cerebellar cortex
middle cerebral artery
another branch of the internal carotid artery; supplies blood to the temporal and parietal lobes of the cerebrum
middle cranial fossa
centrally located cranial fossa that extends from the lesser wings of the sphenoid bone to the petrous ridge
middle ear
space within the temporal bone between the ear canal and bony labyrinth where the ossicles amplify sound waves from the tympanic membrane to the oval window
middle nasal concha
nasal concha formed by the ethmoid bone that is located between the superior and inferior conchae
middle sacral vein
drains the sacral region and leads to the left common iliac vein
middle scalene
longest scalene muscle, located between the anterior and posterior scalenes
migrating motility complex
form of peristalsis in the small intestine
mineralocorticoids
hormones produced by the zona glomerulosa cells of the adrenal cortex that influence fluid and electrolyte balance
minerals
inorganic compounds required by the body to ensure proper function of the body
minimus
smallest
mitochondrion
one of the cellular organelles bound by a double lipid bilayer that function primarily in the production of cellular energy (ATP)
mitosis
division of genetic material, during which the cell nucleus breaks down and two new, fully functional, nuclei are formed
mitotic phase
phase of the cell cycle in which a cell undergoes mitosis
mitotic spindle
network of microtubules, originating from centrioles, that arranges and pulls apart chromosomes during mitosis
mitral valve
(also, left atrioventricular valve or bicuspid valve) valve located between the left atrium and ventricle; consists of two flaps of tissue
mixing wave
unique type of peristalsis that occurs in the stomach
moderator band
band of myocardium covered by endocardium that arises from the inferior portion of the interventricular septum in the right ventricle and crosses to the anterior papillary muscle; contains conductile fibers that carry electrical signals followed by contraction of the heart
molar
tooth used for crushing and grinding food
molecule
two or more atoms covalently bonded together
monocyte
precursor to macrophages and dendritic cells seen in the blood
monocytes
agranular leukocytes of the myeloid stem cell line that circulate in the bloodstream; tissue monocytes are macrophages
monoglyceride molecules
lipid consisting of a single fatty acid chain attached to a glycerol backbone
monosaccharide
monomer of carbohydrate; also known as a simple sugar
monosynaptic reflex
a reflex arc in which the sensory neuron synapses directly with the motor neuron (does not involve an interneuron)
mons pubis
mound of fatty tissue located at the front of the vulva
morula
tightly packed sphere of blastomeres that has reached the uterus but has not yet implanted itself
motilin
hormone that initiates migrating motility complexes
motility
movement of food through the GI tract
motor end-plate
sarcolemma of muscle fiber at the neuromuscular junction, with receptors for the neurotransmitter acetylcholine
motor unit
motor neuron and the group of muscle fibers it innervates
mucosa
innermost lining of the alimentary canal
Mucosa-associated lymphoid tissue (MALT)
lymphoid nodule associated with the mucosa
mucosal barrier
protective barrier that prevents gastric juice from destroying the stomach itself
mucous connective tissue
specialized loose connective tissue present in the umbilical cord
mucous gland
group of cells that secrete mucous, a thick, slippery substance that keeps tissues moist and acts as a lubricant
mucous membrane
tissue membrane that is covered by protective mucous and lines tissue exposed to the outside environment
mucous neck cell
gastric gland cell that secretes a uniquely acidic mucus
Müllerian duct
duct system present in the embryo that will eventually form the internal female reproductive structures
multiaxial joint
type of diarthrosis; a joint that allows for movements within three planes (three axes)
multifidus
muscle of the lumbar region that helps extend and laterally flex the vertebral column
multimodal integration area
region of the cerebral cortex in which information from more than one sensory modality is processed to arrive at higher level cortical functions such as memory, learning, or cognition
multipennate
pennate muscle that has a tendon branching within it
multipolar
shape of a neuron that has multiple processes—the axon and two or more dendrites
multipotent
describes the condition of being able to differentiate into different types of cells within a given cell lineage or small number of lineages, such as a red blood cell or white blood cell
murmur
unusual heart sound detected by auscultation; typically related to septal or valve defects
muscalaris
muscle (skeletal or smooth) layer of the alimentary canal wall
muscarinic receptor
type of acetylcholine receptor protein that is characterized by also binding to muscarine and is a metabotropic receptor
muscle spindle
located in muscle; the specific sensory receptors responsible for providing information about muscle length or the rate of change of the length; a mechanoreceptor & proprioceptor; involved in stretch reflex
muscle tension
force generated by the contraction of the muscle; tension generated during isotonic contractions and isometric contractions
muscle tissue
type of tissue that is capable of contracting and generating tension in response to stimulation; produces movement.
muscle tone
low levels of muscle contraction that occur when a muscle is not producing movement
muscular artery
(also, distributing artery) artery with abundant smooth muscle in the tunica media that branches to distribute blood to the arteriole network
mutation
change in the nucleotide sequence in a gene within a cell’s DNA
mydriasis
dilation of the pupil; typically the result of disease, trauma, or drugs
myelencephalon
secondary vesicle of the embryonic brain that develops into the medulla
myelin
lipid-rich insulating substance surrounding the axons of many neurons, allowing for faster transmission of electrical signals
myelin sheath
lipid-rich layer of insulation that surrounds an axon, formed by oligodendrocytes in the CNS and Schwann cells in the PNS; facilitates the transmission of electrical signals
myeloid stem cells
type of hemopoietic stem cell that gives rise to some formed elements, including erythrocytes, megakaryocytes that produce platelets, and a myeloblast lineage that gives rise to monocytes and three forms of granular leukocytes (neutrophils, eosinophils, and basophils)
myenteric plexus
(plexus of Auerbach) major nerve supply to alimentary canal wall; controls motility
mylohyoid
muscle that lifts the hyoid bone and helps press the tongue to the top of the mouth
mylohyoid line
bony ridge located along the inner (medial) surface of the mandibular body
myoblast
muscle-forming stem cell
myocardial conducting cells
specialized cells that transmit electrical impulses throughout the heart and trigger contraction by the myocardial contractile cells
myocardial contractile cells
bulk of the cardiac muscle cells in the atria and ventricles that conduct impulses and contract to propel blood
myocardium
thickest layer of the heart composed of cardiac muscle cells built upon a framework of primarily collagenous fibers and blood vessels that supply it and the nervous fibers that help to regulate it
myofibril
long, cylindrical organelle that runs parallel within the muscle fiber and contains the sarcomeres
myogenic mechanism
mechanism by which smooth muscle responds to stretch by contracting; an increase in blood pressure causes vasoconstriction and a decrease in blood pressure causes vasodilation so that blood flow downstream remains steady
myogenic response
constriction or dilation in the walls of arterioles in response to pressures related to blood flow; reduces high blood flow or increases low blood flow to help maintain consistent flow to the capillary network
myogram
instrument used to measure twitch tension
myometrium
smooth muscle layer of uterus that allows for uterine contractions during labor and expulsion of menstrual blood
myosin
protein that makes up most of the thick cylindrical myofilament within a sarcomere muscle fiber
myotube
fusion of many myoblast cells

N

NADH
high-energy molecule needed for glycolysis
nail bed
layer of epidermis upon which the nail body forms
nail body
main keratinous plate that forms the nail
nail cuticle
fold of epithelium that extends over the nail bed, also called the eponychium
nail fold
fold of epithelium at that extend over the sides of the nail body, holding it in place
nail root
part of the nail that is lodged deep in the epidermis from which the nail grows
naïve lymphocyte
mature B or T cell that has not yet encountered antigen for the first time
naris
(plural = nares) opening of the nostrils
nasal bone
paired bones that form the base of the nose and are connected to the frontal and maxillary bones
nasal cavity
opening through skull for passage of air
nasal conchae
curved bony plates that project from the lateral walls of the nasal cavity; include the superior and middle nasal conchae, which are parts of the ethmoid bone, and the independent inferior nasal conchae bone
nasal septum
flat, midline wall that divides the left and right nasal cavities, formed by the perpendicular plate of the ethmoid bone, vomer bone, and septal cartilage
nasolacrimal canal
passage for drainage of tears that extends downward from the medial-anterior orbit to the nasal cavity, terminating behind the inferior nasal conchae
nasopharynx
region of the pharynx flanked by the conchae and oropharynx that serves as a passageway for air only
natural killer (NK) cells
cytotoxic lymphocytes capable of recognizing cells that do not express “self” proteins on their plasma membrane or that contain foreign or abnormal markers; provide generalized, nonspecific immunity
natural killer cell (NK)
cytotoxic lymphocyte of innate immune response
navicular
tarsal bone that articulates posteriorly with the talus bone, laterally with the cuboid bone, and anteriorly with the medial, intermediate, and lateral cuneiform bones
neck of the femur
narrowed region located inferior to the head of the femur
neck of the radius
narrowed region immediately distal to the head of the radius
neck of the rib
narrowed region of a rib, next to the rib head
necrosis
accidental death of cells and tissues
negative chronotropic factors
factors that reduce heart rate
negative feedback
homeostatic mechanism that tends to stabilize an upset in the body’s physiological condition by preventing an excessive response to a stimulus, typically as the stimulus is removed
negative inotropic factors
factors that negatively impact or lower heart contractility
negative selection
selection against thymocytes in the thymus that react with self-antigen
neonatal hypothyroidism
condition characterized by cognitive deficits, short stature, and other signs and symptoms in people born to women who were iodine-deficient during pregnancy
nephrons
functional units of the kidney that carry out all filtration and modification to produce urine; consist of renal corpuscles, proximal and distal convoluted tubules, and descending and ascending loops of Henle; drain into collecting ducts
nerve
cord-like bundle of axons located in the peripheral nervous system that transmits sensory input and response output to and from the central nervous system
nerve plexus
network of nerves without neuronal cell bodies included
nervi vasorum
small nerve fibers found in arteries and veins that trigger contraction of the smooth muscle in their walls
nervous tissue
type of tissue that is capable of sending and receiving impulses through electrochemical signals.
net filtration pressure (NFP)
pressure of the force driving out of the capillary and into the tissue spaces; calculated by taking the hydrostatic pressure of the capillary and subtracting the colloid osmotic pressure of the blood; when calculated by the glomerulus, the hydrostatic pressure of Bowman’s capsule is also subtracted
neural crest
tissue that detaches from the edges of the neural groove and migrates through the embryo to develop into peripheral structures of both nervous and non-nervous tissues
neural fold
elevated edge of the neural groove
neural groove
region of the neural plate that folds into the dorsal surface of the embryo and closes off to become the neural tube
neural plate
thickened layer of neuroepithelium that runs longitudinally along the dorsal surface of an embryo and gives rise to nervous system tissue
neural tube
precursor to structures of the central nervous system, formed by the invagination and separation of neuroepithelium
neural tunic
layer of the eye that contains nervous tissue, namely the retina
neuraxis
central axis to the nervous system, from the posterior to anterior ends of the neural tube; the inferior tip of the spinal cord to the anterior surface of the cerebrum
neurogenic shock
type of shock that occurs with cranial or high spinal injuries that damage the cardiovascular centers in the medulla oblongata or the nervous fibers originating from this region
neuroglia
supportive neural cells
neuromuscular junction (NMJ)
synapse between the axon terminal of a motor neuron and the section of the membrane of a muscle fiber with receptors for the acetylcholine released by the terminal
neuron
excitable neural tissue cell that generates and transfers electrical signals into, within, and out of the nervous system
neuropeptide
neurotransmitter type that includes protein molecules and shorter chains of amino acids
neurotransmitter
chemical signal that is released from the synaptic end bulb of a neuron to cause a change in the target cell
neurotransmitter system
the group of neurons that send signals using a specific neurotransmitter and the receptors that bind that neurotransmitter; example: the cholinergic system includes neurons that release acetylcholine which then binds to cholinergic receptors on the next cell
neurulation
embryonic process that establishes the central nervous system
neutralization
inactivation of a virus by the binding of specific antibody
neutron
heavy subatomic particle having no electrical charge and found in the atom’s nucleus
neutrophil
phagocytic white blood cell recruited from the bloodstream to the site of infection via the bloodstream
neutrophils
granulocytes that stain with a neutral dye and are the most numerous of the leukocytes; especially active against bacteria
nicotinamide adenine dinucleotide (NAD)
coenzyme used to produce NADH
nicotinic receptor
type of acetylcholine receptor protein that is characterized by also binding to nicotine and is an ionotropic receptor
nociceptor
sensory receptor cell that is sensitive to chemical stimuli, such as in taste, smell, or pain
node of Ranvier
gap between two myelinated regions of an axon, allowing for strengthening of the electrical signal as it propagates down the axon
nonshivering thermogenesis
process of breaking down brown adipose tissue to produce heat in the absence of a shivering response
nonspecific channel
channel that is not specific to one ion over another, such as a nonspecific cation channel that allows any positively charged ion across the membrane
norepinephrine
(also, noradrenaline), secondary catecholamine hormone released as a neurotransmitter by postganglionic sympathetic fibers as part of the sympathetic response, or as a hormone into the bloodstream from the adrenal medulla
notochord
rod-shaped, mesoderm-derived structure that provides support along the dorsal side of the early embryo and largely disappears during later development; contributes to formation of the intervertebral discs
nuchal ligament
expanded portion of the supraspinous ligament within the posterior neck; interconnects the spinous processes of the cervical vertebrae and attaches to the base of the skull
nuclear envelope
membrane that surrounds the nucleus; consisting of a double lipid-bilayer
nuclear pore
one of the small, protein-lined openings found scattered throughout the nuclear envelope
nucleolus
small region of the nucleus that functions in ribosome synthesis
nucleosidase
brush border enzyme that digests nucleotides
nucleosome
unit of chromatin consisting of a DNA strand wrapped around histone proteins
nucleotide
class of organic compounds composed of one or more phosphate groups, a pentose sugar, and a base
nucleus
cell’s central organelle; contains the cell’s DNA
nucleus ambiguus
brain-stem nucleus that contains neurons that project through the vagus nerve to terminal ganglia in the thoracic cavity; specifically associated with the heart
nucleus cuneatus
medullary nucleus at which first-order neurons of the dorsal column system synapse specifically from the upper body and arms
nucleus gracilis
medullary nucleus at which first-order neurons of the dorsal column system synapse specifically from the lower body and legs
nucleus of the nervous system
in the nervous system, a localized collection of neuron cell bodies that are functionally related; a “center” of neural function
nucleus pulposus
gel-like central region of an intervertebral disc; provides for padding, weight-bearing, and movement between adjacent vertebrae
nutrient foramen
small opening in the middle of the external surface of the diaphysis, through which an artery enters the bone to provide nourishment

O

oblique
at an angle
obstructive shock
type of shock that occurs when a significant portion of the vascular system is blocked
obturator externus
muscle deep to the gluteus maximus on the lateral surface of the thigh that laterally rotates the femur at the hip
obturator foramen
large opening located in the anterior hip bone, between the pubis and ischium regions
obturator internus
muscle deep to the gluteus maximus on the lateral surface of the thigh that laterally rotates the femur at the hip
occipital bone
unpaired bone that forms the posterior portions of the brain case and base of the skull
occipital condyle
paired, oval-shaped bony knobs located on the inferior skull, to either side of the foramen magnum
occipital lobe
region of the cerebral cortex directly beneath the occipital bone of the cranium
occipital sinus
enlarged vein that drains the occipital region near the falx cerebelli and flows into the left and right transverse sinuses, and also into the vertebral veins
occipital sinuses
dural sinuses along the edge of the occipital lobes of the cerebrum
occipitalis
posterior part of the occipitofrontalis muscle
occipitofrontalis
muscle that makes up the scalp with a frontal belly and an occipital belly
oculomotor nerve
first cranial nerve; responsible for the sense of smell
odorant molecules
volatile chemicals that bind to receptor proteins in olfactory neurons to stimulate the sense of smell
olecranon fossa
large depression located on the posterior side of the distal humerus; this space receives the olecranon process of the ulna when the elbow is fully extended
olecranon process
expanded posterior and superior portions of the proximal ulna; forms the bony tip of the elbow
olfaction
sense of smell, which has a unique, direct connection to the limbic system
olfactory bulb
central target of the first cranial nerve; located on the ventral surface of the frontal lobe in the cerebrum
olfactory epithelium
region of the nasal epithelium where olfactory neurons are located
olfactory nerve
systemic nerve of the arm that arises from the brachial plexus
olfactory pit
invaginated ectodermal tissue in the anterior portion of the head region of an embryo that will form the nasal cavity
olfactory sensory neuron
receptor cell of the olfactory system, sensitive to the chemical stimuli of smell, the axons of which compose the first cranial nerve
oligodendrocyte
glial cell type in the CNS that provides the myelin insulation for axons in tracts
oligopotent
describes the condition of being more specialized than multipotency; the condition of being able to differentiate into one of a few possible cell types
omohyoid
muscle that has superior and inferior bellies and depresses the hyoid bone
oocyte
cell that results from the division of the oogonium and undergoes meiosis I at the LH surge and meiosis II at fertilization to become a haploid ovum
oogenesis
process by which oogonia divide by mitosis to primary oocytes, which undergo meiosis to produce the secondary oocyte and, upon fertilization, the ovum
oogonia
ovarian stem cells that undergo mitosis during female fetal development to form primary oocytes
open reduction
surgical exposure of a bone to reset a fracture
ophthalmic artery
branch of the internal carotid artery; supplies blood to the eyes
opponens digiti minimi
muscle that brings the little finger across the palm to meet the thumb
opponens pollicis
muscle that moves the thumb across the palm to meet another finger
opposition
thumb movement that brings the tip of the thumb in contact with the tip of a finger
opsin
protein that contains the photosensitive cofactor retinal for phototransduction
opsonization
enhancement of phagocytosis by the binding of antibody or antimicrobial protein
optic canal
opening spanning between middle cranial fossa and posterior orbit
optic chiasm
decussation point in the visual system at which medial retina fibers cross to the other side of the brain
optic disc
spot on the retina at which RGC axons leave the eye and blood vessels of the inner retina pass
optic nerve
second cranial nerve; responsible for visual sensation
optic tract
name for the fiber structure containing axons from the retina posterior to the optic chiasm representing their CNS location
oral cavity
(also, buccal cavity) mouth
oral vestibule
part of the mouth bounded externally by the cheeks and lips, and internally by the gums and teeth
orbicularis oculi
circular muscle that closes the eye
orbicularis oris
circular muscle that moves the lips
orbit
bony socket that contains the eyeball and associated muscles
organ
functionally distinct structure composed of two or more types of tissues
organ system
group of organs that work together to carry out a particular function
organelle
any of several different types of membrane-enclosed specialized structures in the cell that perform specific functions for the cell
organelles
any of several different types of membrane-enclosed specialized structures in the cell that perform specific functions for the cell
organic compound
substance that contains both carbon and hydrogen
organogenesis
development of the rudimentary structures of all of an embryo’s organs from the germ layers
organs of Corti
structure in the cochlea in which hair cells transduce movements from sound waves into electrochemical signals
origin
end of a skeletal muscle that is attached to another structure (usually a bone) in a fixed position
oropharynx
region of the pharynx flanked by the nasopharynx, oral cavity, and laryngopharynx that serves as a passageway for both air and food
orthopedist
doctor who specializes in diagnosing and treating musculoskeletal disorders and injuries
orthostatic reflex
sympathetic function that maintains blood pressure when standing to offset the increased effect of gravity
osmoreceptor
receptor cell that senses differences in the concentrations of bodily fluids on the basis of osmotic pressure
osmosis
diffusion of water molecules down their concentration gradient across a selectively permeable membrane
ossicles
three small bones in the middle ear
ossification
(also, osteogenesis) bone formation
ossification center
cluster of osteoblasts found in the early stages of intramembranous ossification
osteoblast
cell responsible for forming new bone
osteoclast
cell responsible for resorbing bone
osteocyte
primary cell in mature bone; responsible for maintaining the matrix
osteogenic cell
undifferentiated cell with high mitotic activity; the only bone cells that divide; they differentiate and develop into osteoblasts
osteoid
uncalcified bone matrix secreted by osteoblasts, contains collagen and collagen pre-cursors
osteomalacia
softening of bones due to a lack of mineralization with calcium and phosphate; most often due to lack of vitamin D; in children, osteomalacia is termed rickets; not to be confused with osteoporosis
osteon
(also, Haversian system) basic structural unit of compact bone; made of concentric layers of calcified matrix
osteoporosis
disease characterized by a decrease in bone mass; occurs when the rate of bone resorption exceeds the rate of bone formation, a common occurrence as the body ages
otolithic membrane
gelatinous substance in the utricle and saccule of the inner ear that contains calcium carbonate crystals and into which the stereocilia of hair cells are embedded
outer segment
in the eye, the section of a photoreceptor that contains opsin molecules that transduce light stimuli
outer synaptic layer
layer in the retina at which photoreceptors connect to bipolar cells
oval window
membrane at the base of the cochlea where the stapes attaches, marking the beginning of the scala vestibuli
ovarian artery
branch of the abdominal aorta; supplies blood to the ovary, uterine (Fallopian) tube, and uterus
ovarian cycle
approximately 28-day cycle of changes in the ovary consisting of a follicular phase and a luteal phase
ovarian vein
drains the ovary; the right ovarian vein leads to the inferior vena cava and the left ovarian vein leads to the left renal vein
ovaries
female gonads that produce oocytes and sex steroid hormones (notably estrogen and progesterone)
ovulation
release of a secondary oocyte and associated granulosa cells from an ovary
ovum
haploid female gamete resulting from completion of meiosis II at fertilization
oxidation
loss of an electron
oxidation-reduction reaction
(also, redox reaction) pair of reactions in which an electron is passed from one molecule to another, oxidizing one and reducing the other
oxidative phosphorylation
process that converts high-energy NADH and FADH2 into ATP
oxygen debt
amount of oxygen needed to compensate for ATP produced without oxygen during muscle contraction
oxygen deficit
The shortage of oxygen delivery to working muscles at the beginning of intense exercise
oxygen–hemoglobin dissociation curve
graph that describes the relationship of partial pressure to the binding and disassociation of oxygen to and from heme
oxyhemoglobin
(Hb–O2) molecule of hemoglobin to which oxygen is bound
oxytocin
hypothalamic hormone stored in the posterior pituitary gland and important in stimulating uterine contractions in labor, milk ejection during breastfeeding, and feelings of attachment (also produced in males)

P

P wave
component of the electrocardiogram that represents the depolarization of the atria
pacemaker
cluster of specialized myocardial cells known as the SA node that initiates the sinus rhythm
pacesetter cell
cell that triggers action potentials in smooth muscle
Pacinian corpuscle
(also, lamellated corpuscle) receptor in the skin that responds to vibration
packed cell volume (PCV)
(also, hematocrit) volume percentage of erythrocytes present in a sample of centrifuged blood
palatine bone
paired bones that form the posterior quarter of the hard palate and a small area in floor of the orbit
palatine process
medial projection from the maxilla bone that forms the anterior three quarters of the hard palate
palatine tonsil
one of the paired structures composed of lymphoid tissue located anterior to the uvula at the roof of isthmus of the fauces
palatoglossal arch
muscular fold that extends from the lateral side of the soft palate to the base of the tongue
palatoglossus
muscle that originates on the soft palate to elevate the back of the tongue
palatopharyngeal arch
muscular fold that extends from the lateral side of the soft palate to the side of the pharynx
palmar arches
superficial and deep arches formed from anastomoses of the radial and ulnar arteries; supply blood to the hand and digital arteries
palmar interossei
muscles that abduct and flex each finger at the metacarpophalangeal joints and extend each finger at the interphalangeal joints
palmar venous arches
drain the hand and digits, and feed into the radial and ulnar veins
palmaris longus
muscle that provides weak flexion of the hand at the wrist
palpebral conjunctiva
membrane attached to the inner surface of the eyelids that covers the anterior surface of the cornea
pancreas
organ with both exocrine and endocrine functions located posterior to the stomach; an important accessory digestive organ and regulator of blood glucose
pancreatic amylase
enzyme secreted by the pancreas that participates in nucleic acid digestion
pancreatic islets
specialized clusters of pancreatic cells that have endocrine functions; also called islets of Langerhans
pancreatic juice
secretion of the pancreas containing digestive enzymes and bicarbonate
pancreatic lipase
enzyme secreted by the pancreas that participates in lipid digestion
pancreatic lipases
enzymes released from the pancreas that digest lipids in the diet
pancreatic nuclease
enzyme secreted by the pancreas that participates in nucleic acid digestion
pancreatic polypeptide cell
minor cell type in the pancreas that secretes the hormone pancreatic polypeptide
papilla
for gustation, a bump-like projection on the surface of the tongue that contains taste buds
papillary layer
superficial layer of the dermis, made of loose, areolar connective tissue
papillary muscle
extension of the myocardium in the ventricles to which the chordae tendineae attach
paracrine
chemical signal that elicits a response in neighboring cells; also called paracrine factor
parallel
fascicles that extend in the same direction as the long axis of the muscle
paramedian pontine reticular formation (PPRF)
region of the brain stem adjacent to the motor nuclei for gaze control that coordinates rapid, conjugate eye movements
paranasal sinus
one of the cavities within the skull that is connected to the conchae that serve to warm and humidify incoming air, produce mucus, and lighten the weight of the skull; consists of frontal, maxillary, sphenoidal, and ethmoidal sinuses
paranasal sinuses
cavities within the skull that are connected to the conchae that serve to warm and humidify incoming air, produce mucus, and lighten the weight of the skull; consist of frontal, maxillary, sphenoidal, and ethmoidal sinuses
parasympathetic division
division of the autonomic nervous system responsible for restful and digestive functions
parasympathomimetic drugs
drugs that enhance or mimic the function of the parasympathetic system
parathyroid glands
small, round glands embedded in the posterior thyroid gland that produce parathyroid hormone (PTH)
parathyroid hormone (PTH)
peptide hormone produced and secreted by the parathyroid glands in response to low blood calcium levels
paravertebral ganglia
autonomic ganglia superior to the sympathetic chain ganglia
parenchyma
functional cells of a gland or organ, in contrast with the supportive or connective tissue of a gland or organ
paresis
partial loss of, or impaired, voluntary muscle control
parietal bone
paired bones that form the upper, lateral sides of the skull
parietal branches
(also, somatic branches) group of arterial branches of the thoracic aorta; includes those that supply blood to the thoracic cavity, vertebral column, and the superior surface of the diaphragm
parietal cell
gastric gland cell that secretes hydrochloric acid and intrinsic factor
parietal lobe
region of the cerebral cortex directly beneath the parietal bone of the cranium
parietal pleura
outermost layer of the pleura that connects to the thoracic wall, mediastinum, and diaphragm
parieto-occipital sulcus
groove in the cerebral cortex representing the border between the parietal and occipital cortices
parotid gland
one of a pair of major salivary glands located inferior and anterior to the ears
partial pressure
force exerted by each gas in a mixture of gases
parturition
childbirth
passive immunity
transfer of immunity to a pathogen to an individual that lacks immunity to this pathogen usually by the injection of antibodies
patella
kneecap; the largest sesamoid bone of the body; articulates with the distal femur
patellar ligament
ligament spanning from the patella to the anterior tibia; extension of the quadriceps tendon which serves as the distal attachment for the muscles of the quadriceps femoris
patellar surface
smooth groove located on the anterior side of the distal femur, between the medial and lateral condyles; site of articulation for the patella
pattern recognition receptor (PRR)
leukocyte receptor that binds to specific cell wall components of different bacterial species
pectinate line
horizontal line that runs like a ring, perpendicular to the inferior margins of the anal sinuses
pectinate muscles
muscular ridges seen on the anterior surface of the right atrium
pectineal line
narrow ridge located on the superior surface of the superior pubic ramus
pectineus
muscle that abducts and flexes the femur at the hip
pectoral girdle
(also, shoulder girdle) the set of bones, consisting of the scapula and clavicle, which attaches an upper limb to the axial skeleton at the sternum
pectoralis major
thick, fan-shaped axial muscle that covers much of the superior thorax
pectoralis minor
muscle that moves the scapula and assists in inhalation
pedicels
finger-like projections of podocytes surrounding glomerular capillaries; interdigitate to form a filtration membrane
pedicle
portion of the vertebral arch that extends from the vertebral body to the transverse process
pelvic brim
pelvic inlet; the dividing line between the greater and lesser pelvic regions; formed by the superior margin of the pubic symphysis, the pectineal lines of each pubis, the arcuate lines of each ilium, and the sacral promontory
pelvic diaphragm
muscular sheet that comprises the levator ani and the ischiococcygeus
pelvic girdle
(also, hip girdle) consists of a single hip bone, which attaches a lower limb to the axial skeleton at the sacrum
pelvic inlet
pelvic brim
pelvic outlet
inferior opening of the lesser pelvis; formed by the inferior margin of the pubic symphysis, right and left ischiopubic rami and sacrotuberous ligaments, and the tip of the coccyx
pelvis
ring of bone consisting of the right and left hip bones, the sacrum, and the coccyx
penis
male organ of copulation
pennate
fascicles that are arranged differently based on their angles to the tendon
pepsin
enzyme that begins to break down proteins in the stomach
pepsinogen
inactive form of pepsin
peptide bond
covalent bond formed by dehydration synthesis between two amino acids
perforating canal
(also, Volkmann’s canal) channel that branches off from the central canal and houses vessels and nerves that extend to the periosteum and endosteum
perforin
molecule in NK cell and cytotoxic T cell granules that form pores in the membrane of a target cell
perfusion
distribution of blood into the capillaries so the tissues can be supplied
pericardial artery
branch of the thoracic aorta; supplies blood to the pericardium
pericardial cavity
cavity surrounding the heart filled with a lubricating serous fluid that reduces friction as the heart contracts
pericardial sac
(also, pericardium) membrane that separates the heart from other mediastinal structures; consists of two distinct, fused sublayers: the fibrous pericardium and the parietal pericardium
pericardium
(also, pericardial sac) membrane that separates the heart from other mediastinal structures; consists of two distinct, fused sublayers: the fibrous pericardium and the parietal pericardium
perichondrium
membrane that covers cartilage
pericyte
stem cell that regenerates smooth muscle cells
perimetrium
outer epithelial layer of uterine wall
perimysium
connective tissue that bundles skeletal muscle fibers into fascicles within a skeletal muscle
perineum
diamond-shaped region between the pubic symphysis, coccyx, and ischial tuberosities
perineurium
layer of connective tissue surrounding fascicles within a nerve
periodic table of the elements
arrangement of the elements in a table according to their atomic number; elements having similar properties because of their electron arrangements compose columns in the table, while elements having the same number of valence shells compose rows in the table
periodontal ligament
band of dense connective tissue that anchors the root of a tooth into the bony jaw socket
periosteum
fibrous membrane covering the outer surface of bone and continuous with ligaments
peripheral chemoreceptor
one of the specialized receptors located in the aortic arch and carotid arteries that sense changes in pH, carbon dioxide, or oxygen blood levels
peripheral nervous system (PNS)
anatomical division of the nervous system that extends from the brain and spinal cord to the rest of the body
peripheral tolerance
mature B cell made tolerant by lack of T cell help
peristalsis
muscular contractions and relaxations that propel food through the GI tract
peritubular capillaries
second capillary bed of the renal portal system; surround the proximal and distal convoluted tubules; associated with the vasa recta
permanent tooth
one of 32 adult teeth
peroxisome
membrane-bound organelle that contains enzymes primarily responsible for detoxifying harmful substances
perpendicular plate of the ethmoid bone
downward, midline extension of the ethmoid bone that forms the superior portion of the nasal septum
petrosal sinus
enlarged vein that receives blood from the cavernous sinus and flows into the internal jugular vein
petrous ridge
petrous portion of the temporal bone that forms a large, triangular ridge in the floor of the cranial cavity, separating the middle and posterior cranial fossae; houses the middle and inner ear structures
pH
negative logarithm of the hydrogen ion (H+) concentration of a solution
phagocytosis
endocytosis of large particles via vesicles made from invaginations of the plasma membrane
phalanx bone of the foot
(plural = phalanges) one of the 14 bones that form the toes; these include the proximal and distal phalanges of the big toe, and the proximal, middle, and distal phalanx bones of toes two through five
phalanx bone of the hand
(plural = phalanges) one of the 14 bones that form the thumb and fingers; these include the proximal and distal phalanges of the thumb, and the proximal, middle, and distal phalanx bones of the fingers two through five
pharyngeal tonsil
structure composed of lymphoid tissue located in the nasopharynx
pharynx
tube of skeletal muscle located between the nasal conchae and the esophagus and trachea
phenotype
physical or biochemical manifestation of the genotype; expression of the alleles
philtrum
concave surface of the face that connects the apex of the nose to the top lip
phosphatase
brush border enzyme that digests nucleotides
phosphodiesterase (PDE)
cytosolic enzyme that deactivates and degrades cAMP
phospholipid
a lipid compound in which a phosphate group is combined with a diglyceride
phosphorylation
addition of one or more phosphate groups to an organic compound
phosphorylation cascade
signaling event in which multiple protein kinases phosphorylate the next protein substrate by transferring a phosphate group from ATP to the protein
photoisomerization
chemical change in the retinal molecule that alters the bonding so that it switches from the 11-cis-retinal isomer to the all-trans-retinal isomer
photon
individual “packet” of light
photoreceptor
receptor cell specialized to respond to light stimuli
phrenic nerve
systemic nerve from the cervical plexus that innervates the diaphragm
phrenic vein
drains the diaphragm; the right phrenic vein flows into the inferior vena cava and the left phrenic vein leads to the left renal vein
physiological sphincter
sphincter consisting of circular smooth muscle indistinguishable from adjacent muscle but possessing differential innervations, permitting its function as a sphincter; structurally weak
physiology
science that studies the chemistry, biochemistry, and physics of the body’s functions
pia mater
thin, innermost membrane of the meninges that directly covers the surface of the CNS
pineal gland
endocrine gland that secretes melatonin, which is important in regulating the sleep-wake cycle
pinealocyte
cell of the pineal gland that produces and secretes the hormone melatonin
pinocytosis
endocytosis of fluid
piriformis
muscle deep to the gluteus maximus on the lateral surface of the thigh that laterally rotates the femur at the hip
pisiform
from the lateral side, the fourth of the four proximal carpal bones; articulates with the anterior surface of the triquetrum
pituitary dwarfism
disorder in children caused when abnormally low levels of GH result in growth retardation
pituitary gland
bean-sized organ suspended from the hypothalamus that produces, stores, and secretes hormones in response to hypothalamic stimulation (also called hypophysis)
pivot joint
synovial joint at which the rounded portion of a bone rotates within a ring formed by a ligament and an articulating bone; functionally classified as uniaxial joint
placenta
organ that forms during pregnancy to nourish the developing fetus; also regulates waste and gas exchange between mother and fetus
placenta previa
low placement of fetus within uterus causes placenta to partially or completely cover the opening of the cervix as it grows
placentation
formation of the placenta; complete by weeks 14–16 of pregnancy
plane
imaginary two-dimensional surface that passes through the body
plane joint
synovial joint formed between the flattened articulating surfaces of adjacent bones; functionally classified as a multiaxial joint
plantar aponeurosis
muscle that supports the longitudinal arch of the foot
plantar arch
formed from the anastomosis of the dorsalis pedis artery and medial and plantar arteries; branches supply the distal portions of the foot and digits
plantar flexion
foot movement at the ankle in which the heel is lifted off of the ground
plantar group
four-layered group of intrinsic foot muscles
plantar reflex
superficial reflex initiated by gentle stimulation of the sole of the foot
plantar veins
drain the foot and lead to the plantar venous arch
plantar venous arches
drain the hand and digits, and feed into the radial and ulnar veins
plantaris
muscle that runs obliquely between the gastrocnemius and the soleus
plasma
in blood, the liquid extracellular matrix composed mostly of water that circulates the formed elements and dissolved materials throughout the cardiovascular system
plasma cell
differentiated B cell that is actively secreting antibody
plasma osmolality
ratio of solutes to a volume of solvent in the plasma; plasma osmolality reflects a person’s state of hydration
plasmin
blood protein active in fibrinolysis
platelet plug
accumulation and adhesion of platelets at the site of blood vessel injury
platelets
(also, thrombocytes) one of the formed elements of blood that consists of cell fragments broken off from megakaryocytes
pleural cavity
space between the visceral and parietal pleurae
pleural fluid
substance that acts as a lubricant for the visceral and parietal layers of the pleura during the movement of breathing
plexus
network of nerves or nervous tissue
pluripotent
describes the condition of being able to differentiate into a large variety of cell types
pluripotent stem cell
stem cell that derives from totipotent stem cells and is capable of differentiating into many, but not all, cell types
pneumotaxic center
network of neurons within the pons that inhibit the activity of the neurons in the dorsal respiratory group; controls rate of breathing
podocytes
cells forming finger-like processes; form the visceral layer of Bowman’s capsule; pedicels of the podocytes interdigitate to form a filtration membrane
polar body
smaller cell produced during the process of meiosis in oogenesis
polar molecule
molecule with regions that have opposite charges resulting from uneven numbers of electrons in the nuclei of the atoms participating in the covalent bond
pollex
(also, thumb) digit 1 of the hand
polyclonal response
response by multiple clones to a complex antigen with many determinants
polycythemia
elevated level of hemoglobin, whether adaptive or pathological
polymorphonuclear
having a lobed nucleus, as seen in some leukocytes
polysaccharide
complex carbohydrates consisting of more than two carbohydrate monomers (monosaccharides) bonded by dehydration synthesis via glycosidic bonds
polyspermy
penetration of an oocyte by more than one sperm
polysynaptic reflex
a reflex that uses one or more interneuron and involves more than one synapse between the sensory neuron and motor neuron
popliteal artery
continuation of the femoral artery posterior to the knee; branches into the anterior and posterior tibial arteries
popliteal fossa
diamond-shaped space at the back of the knee
popliteal vein
continuation of the femoral vein behind the knee; drains the region behind the knee and forms from the fusion of the fibular and anterior and posterior tibial veins
popliteus
muscle that flexes the leg at the knee and creates the floor of the popliteal fossa
porta hepatis
“gateway to the liver” where the hepatic artery and hepatic portal vein enter the liver
portal triad
bile duct, hepatic artery branch, and hepatic portal vein branch
positive chemotaxis
process in which a cell is attracted to move in the direction of chemical stimuli
positive chronotropic factors
factors that increase heart rate
positive feedback
mechanism that intensifies a change in the body’s physiological condition in response to a stimulus
positive inotropic factors
factors that positively impact or increase heart contractility
positive selection
selection of thymocytes within the thymus that interact with self, but not non-self, MHC molecules
positron emission tomography (PET)
medical imaging technique in which radiopharmaceuticals are traced to reveal metabolic and physiological functions in tissues
postabsorptive state
also called the fasting state; the metabolic state occurring after digestion when food is no longer the body’s source of energy and it must rely on stored glycogen
postcentral gyrus
ridge just posterior to the central sulcus, in the parietal lobe, where somatosensory processing initially takes place in the cerebrum
posterior
describes the back or direction toward the back of the body; also referred to as dorsal
posterior (dorsal) sacral foramen
one of the series of paired openings located on the posterior (dorsal) side of the sacrum
posterior arch
posterior portion of the ring-like C1 (atlas) vertebra
posterior cardiac vein
vessel that parallels and drains the areas supplied by the marginal artery branch of the circumflex artery; drains into the great cardiac vein
posterior cerebral artery
branch of the basilar artery that forms a portion of the posterior segment of the arterial circle; supplies blood to the posterior portion of the cerebrum and brain stem
posterior columns
white matter of the spinal cord that lies between the posterior horns of the gray matter, sometimes referred to as the dorsal column; composed of axons of ascending tracts that carry sensory information up to the brain
posterior communicating artery
branch of the posterior cerebral artery that forms part of the posterior portion of the arterial circle; supplies blood to the brain
posterior compartment of the leg
region that includes the superficial gastrocnemius, soleus, and plantaris, and the deep popliteus, flexor digitorum longus, flexor hallucis longus, and tibialis posterior
posterior compartment of the thigh
region that includes muscles that flex the leg and extend the thigh
posterior cranial fossa
deepest and most posterior cranial fossa; extends from the petrous ridge to the occipital bone
posterior cruciate ligament
intracapsular ligament of the knee; extends from the posterior, superior surface of the tibia to the inner aspect of the medial condyle of the femur; prevents anterior displacement of the femur when the knee is flexed and weight bearing
posterior horn
gray matter region of the spinal cord in which sensory input arrives, sometimes referred to as the dorsal horn
posterior inferior iliac spine
small, bony projection located at the inferior margin of the auricular surface on the posterior ilium
posterior interventricular artery
(also, posterior descending artery) branch of the right coronary artery that runs along the posterior portion of the interventricular sulcus toward the apex of the heart and gives rise to branches that supply the interventricular septum and portions of both ventricles
posterior interventricular sulcus
sulcus located between the left and right ventricles on the anterior surface of the heart
posterior longitudinal ligament
ligament that runs the length of the vertebral column, uniting the posterior sides of the vertebral bodies
posterior median sulcus
midline feature of the posterior spinal cord, marking the separation between right and left sides of the cord
posterior sacroiliac ligament
strong ligament spanning the sacrum and ilium of the hip bone that supports the posterior side of the sacroiliac joint
posterior scalene
smallest scalene muscle, located posterior to the middle scalene
posterior superior iliac spine
rounded, posterior end of the iliac crest
posterior talofibular ligament
intrinsic ligament located on the lateral side of the ankle joint, between the talus bone and lateral malleolus of the fibula; supports the talus at the talocrural joint and resists excess inversion of the foot
posterior tibial artery
branch from the popliteal artery that gives rise to the fibular or peroneal artery; supplies blood to the posterior tibial region
posterior tibial vein
forms from the dorsal venous arch; drains the area near the posterior surface of the tibia and leads to the popliteal vein
posterolateral sulcus
feature of the posterior spinal cord marking the entry of posterior nerve roots and the separation between the posterior and lateral columns of the white matter
postganglionic fiber
axon from a ganglionic neuron in the autonomic nervous system that projects to and synapses with the target effector; sometimes referred to as a postganglionic neuron
postsynaptic potential (PSP)
graded potential in the postsynaptic membrane caused by the binding of neurotransmitter to protein receptors
potential energy
stored energy matter possesses because of the positioning or structure of its components
power lever
the effort arm is longer than the load arm which allows a lever system to move a large load across a small distance
power stroke
action of myosin pulling actin inward (toward the M line)
praxis
in a neurological exam, the act of doing something using ready knowledge or skills in response to verbal instruction
precapillary sphincters
circular rings of smooth muscle that surround the entrance to a capillary and regulate blood flow into that capillary
precentral gyrus
primary motor cortex located in the frontal lobe of the cerebral cortex
precentral gyrus of the frontal cortex
region of the cerebral cortex responsible for generating motor commands, where the upper motor neuron cell body is located
prefrontal lobe
specific region of the frontal lobe anterior to the more specific motor function areas, which can be related to the early planning of movements and intentions to the point of being personality-type functions
preganglionic fiber
axon from a central neuron in the autonomic nervous system that projects to and synapses with a ganglionic neuron; sometimes referred to as a preganglionic neuron
preload
(also, end diastolic volume) amount of blood in the ventricles at the end of atrial systole just prior to ventricular contraction
premolar
(also, bicuspid) transitional tooth used for mastication, crushing, and grinding food
premotor area
region of the frontal lobe responsible for planning movements that will be executed through the primary motor cortex
premotor cortex
cortical area anterior to the primary motor cortex that is responsible for planning movements
prepotential depolarization
(also, spontaneous depolarization) mechanism that accounts for the autorhythmic property of cardiac muscle; the membrane potential increases as sodium ions diffuse through the always-open sodium ion channels and causes the electrical potential to rise
prepuce
(also, foreskin) flap of skin that forms a collar around, and thus protects and lubricates, the glans penis; also referred as the foreskin
prevertebral ganglia
autonomic ganglia that are anterior to the vertebral column and functionally related to the sympathetic chain ganglia
primary adaptive response
immune system’s response to the first exposure to a pathogen
primary curvature
anteriorly concave curvatures of the thoracic and sacrococcygeal regions that are retained from the original fetal curvature of the vertebral column
primary follicles
ovarian follicles with a primary oocyte and one layer of cuboidal granulosa cells
primary lymphoid organ
site where lymphocytes mature and proliferate; red bone marrow and thymus gland
primary ossification center
region, deep in the diaphysis, where bone development starts during endochondral ossification
primary sensory cortex
region of the cerebral cortex that initially receives sensory input from an ascending pathway from the thalamus and begins the processing that will result in conscious perception of that modality
primary union
condition of a wound where the wound edges are close enough to be brought together and fastened if necessary, allowing quicker and more thorough healing
primary vesicle
initial enlargements of the anterior neural tube during embryonic development that develop into the forebrain, midbrain, and hindbrain
prime mover
(also, agonist) principle muscle involved in an action
primitive atrium
portion of the primitive heart tube that eventually becomes the anterior portions of both the right and left atria, and the two auricles
primitive heart tube
singular tubular structure that forms from the fusion of the two endocardial tubes
primitive streak
indentation along the dorsal surface of the epiblast through which cells migrate to form the endoderm and mesoderm during gastrulation
primitive ventricle
portion of the primitive heart tube that eventually forms the left ventricle
primordial follicles
least developed ovarian follicles that consist of a single oocyte and a single layer of flat (squamous) granulosa cells
principal cell
found in collecting ducts and possess channels for the recovery or loss of sodium and potassium; under the control of aldosterone; also have aquaporin channels under ADH control to regulate recovery of water
procedural memory
memory of how to perform a specific task
product
one or more substances produced by a chemical reaction
progesterone
predominantly female sex hormone important in regulating the female reproductive cycle and the maintenance of pregnancy
projection
bone markings where part of the surface sticks out above the rest of the surface, where tendons and ligaments attach
prolactin
pituitary hormone that establishes and maintains the supply of breast milk; also important for the mobilization of maternal micronutrients for breast milk
prolactin (PRL)
anterior pituitary hormone that promotes development of the mammary glands and the production of breast milk
proliferative phase
phase of the menstrual cycle in which the endometrium proliferates
proliferative zone
region of the epiphyseal plate that makes new chondrocytes to replace those that die at the diaphyseal end of the plate and contributes to longitudinal growth of the epiphyseal plate
pronated position
forearm position in which the palm faces backward
pronation
forearm motion that moves the palm of the hand from the palm forward to the palm backward position
pronator drift
sign of contralateral corticospinal lesion when the one arm will drift into a pronated position when held straight out with the palms facing upward
pronator quadratus
pronator that originates on the ulna and inserts on the radius
pronator teres
pronator that originates on the humerus and inserts on the radius
prone
face down
propagation
movement of an action potential along the length of an axon
prophase
first stage of mitosis (and meiosis), characterized by breakdown of the nuclear envelope and condensing of the chromatin to form chromosomes
proprioception
general sensory perceptions providing information about location and movement of body parts; the “sense of the self”
proprioceptor
receptor cell that senses changes in the position and kinesthetic aspects of the body
propulsion
voluntary process of swallowing and the involuntary process of peristalsis that moves food through the digestive tract
prosencephalon
primary vesicle of the embryonic brain that develops into the forebrain, which includes the cerebrum and diencephalon
prostaglandin
lipid compound derived from fatty acid chains and important in regulating several body processes
prostate gland
doughnut-shaped gland at the base of the bladder surrounding the urethra and contributing fluid to semen during ejaculation
protein
class of organic compounds that are composed of many amino acids linked together by peptide bonds
protein kinase
enzyme that initiates a phosphorylation cascade upon activation
proteolysis
process of breaking proteins into smaller peptides
proteome
full complement of proteins produced by a cell (determined by the cell’s specific gene expression)
proton
heavy subatomic particle having a positive charge and found in the atom’s nucleus
protraction
anterior motion of the scapula or mandible
proximal
describes a position nearer to the point of attachment or the trunk of the body
proximal convoluted tubules (PCTs)
tortuous tubules receiving filtrate from Bowman’s capsule; most active part of the nephron in reabsorption and secretion
proximal radioulnar joint
formed by the articulation between the head of the radius and the radial notch of the ulna; uniaxial pivot joint that allows for rotation of radius during pronation/supination of forearm
proximal tibiofibular joint
articulation between the head of the fibula and the inferior aspect of the lateral condyle of the tibia
pseudostratified columnar epithelium
tissue that consists of a single layer of irregularly shaped and sized cells that give the appearance of multiple layers; found in ducts of certain glands and the upper respiratory tract
psoas major
muscle that, along with the iliacus, makes up the iliopsoas
psychoneuroimmunology
study of the connections between the immune, nervous, and endocrine systems
pterion
H-shaped suture junction region that unites the frontal, parietal, temporal, and sphenoid bones on the lateral side of the skull
puberty
life stage during which a male or female adolescent becomes anatomically and physiologically capable of reproduction
pubic arch
bony structure formed by the pubic symphysis, and the bodies and inferior pubic rami of the right and left pubic bones
pubic body
enlarged, medial portion of the pubis region of the hip bone
pubic symphysis
joint formed by the articulation between the pubic bodies of the right and left hip bones
pubic tubercle
small bump located on the superior aspect of the pubic body
pubis
anterior portion of the hip bone
pubococcygeus
muscle that makes up the levator ani along with the iliococcygeus
pubofemoral ligament
intrinsic ligament spanning from the pubis of the hip bone to the femur, on the anterior-inferior aspect of the hip joint
pulmonary arteries
paired arteries formed by the division of pulmonary trunk carrying deoxygenated aterial blood to the lungs
pulmonary capillaries
capillaries surrounding the alveoli of the lungs where gas exchange occurs: carbon dioxide exits the blood and oxygen enters
pulmonary circuit
system of blood vessels that carries blood to the lungs for gas exchange to occur and then returns blood to the heart
pulmonary plexus
network of autonomic nervous system fibers found near the hilum of the lung
pulmonary surfactant
substance composed of phospholipids and proteins that reduces the surface tension of the alveoli; made by type II alveolar cells
pulmonary trunk
large arterial vessel that carries blood ejected from the right ventricle; divides into the left and right pulmonary arteries
pulmonary valve
(also, pulmonary semilunar valve, the pulmonic valve, or the right semilunar valve) valve at the base of the pulmonary trunk that prevents backflow of blood into the right ventricle; consists of three flaps
pulmonary veins
two sets of paired vessels, one pair on each side, formed from the small venules that carry highly oxygenated blood to the left atrium
pulmonary ventilation
exchange of gases between the lungs and the atmosphere; breathing
pulp cavity
deepest portion of a tooth, containing nerve endings and blood vessels
pulse
alternating expansion and recoil of an artery as blood moves through the vessel; an indicator of heart rate
pulse pressure
difference between the systolic and diastolic pressures
Punnett square
grid used to display all possible combinations of alleles transmitted by parents to offspring and predict the mathematical probability of offspring inheriting a given genotype
pupil
open hole at the center of the iris that light passes through into the eye
purine
nitrogen-containing base with a double ring structure; adenine and guanine
Purkinje fibers
specialized myocardial conduction fibers that arise from the bundle branches and spread the impulse to the myocardial contraction fibers of the ventricles
putamen
nucleus deep in the cerebrum that is part of the basal nuclei; along with the caudate, it is part of the striatum
pyloric antrum
wider, more superior part of the pylorus
pyloric canal
narrow, more inferior part of the pylorus
pyloric sphincter
sphincter that controls stomach emptying
pylorus
lower, funnel-shaped part of the stomach that is continuous with the duodenum
pyramidal decussation
location at which corticospinal tract fibers cross the midline and segregate into the anterior and lateral divisions of the pathway
pyramidine
nitrogen-containing base with a single ring structure; cytosine, thiamine, and uracil
pyramids
segment of the descending motor pathway that travels in the anterior position of the medulla
pyruvate
three-carbon end product of glycolysis that can be used in aerobic respiration or converted to lactate

Q

QRS complex
component of the electrocardiogram that represents the depolarization of the ventricles and includes, as a component, the repolarization of the atria
quadratus femoris
muscle deep to the gluteus maximus on the lateral surface of the thigh that laterally rotates the femur at the hip
quadratus lumborum
posterior part of the abdominal wall that helps with posture and stabilization of the body
quadriceps femoris group
four muscles, that extend and stabilize the knee
quadriceps tendon
(also, patellar tendon) tendon common to all four quadriceps muscles, inserts into the patella
quickening
fetal movements that are strong enough to be felt by the mother
quiet breathing

R

(also, eupnea) mode of breathing that occurs at rest and does not require the cognitive thought of the individual
radial artery
formed at the bifurcation of the brachial artery; parallels the radius; gives off smaller branches until it reaches the carpal region where it fuses with the ulnar artery to form the superficial and deep palmar arches; supplies blood to the lower arm and carpal region
radial collateral ligament
intrinsic ligament on the lateral side of the elbow joint; runs from the lateral epicondyle of humerus to merge with the annular ligament
radial fossa
small depression located on the anterior humerus above the capitulum; this space receives the head of the radius when the elbow is maximally flexed
radial nerve
systemic nerve of the arm, the distal component of which is located near the radial bone
radial notch of the ulna
small, smooth area on the lateral side of the proximal ulna; articulates with the head of the radius as part of the proximal radioulnar joint
radial tuberosity
oval-shaped, roughened protuberance located on the medial side of the proximal radius
radial vein
parallels the radius and radial artery; arises from the palmar venous arches and leads to the brachial vein
radiation
transfer of heat via infrared waves
radioactive isotope
unstable, heavy isotope that gives off subatomic particles, or electromagnetic energy, as it decays; also called radioisotopes
radiocarpal joint
wrist joint, located between the forearm and hand regions of the upper limb; articulation formed proximally by the distal end of the radius and the fibrocartilaginous pad that unites the distal radius and ulna bone, and distally by the scaphoid, lunate, and triquetrum carpal bones
radius
bone located on the lateral side of the forearm
ramus of the mandible
vertical portion of the mandible
reabsorption
in the cardiovascular system, the movement of material from the interstitial fluid into the capillaries
reactant
one or more substances that enter into the reaction
reactive oxygen species (ROS)
a group of extremely reactive peroxides and oxygen-containing radicals that may contribute to cellular damage
receptive aphasia
loss of the ability to understand received language, such as what is spoken to the subject or given in written form
receptor
protein molecule that contains a binding site for another specific molecule (called a ligand)
receptor cell
cell that transduces environmental stimuli into neural signals
receptor potential
graded potential in a specialized sensory cell that directly causes the release of neurotransmitter without an intervening action potential
receptor-mediated endocytosis
endocytosis of ligands attached to membrane-bound receptors
recessive
describes a trait that is only expressed in homozygous form and is masked in heterozygous form
recessive lethal
inheritance pattern in which individuals with two copies of a lethal allele do not survive in utero or have a shortened life span
reciprocal activation
when the primary response of a reflex inhibits a muscle, reciprocal activation refers to activation of the antagonist muscle which occurs synchronously to the primary inhibition
reciprocal inhibition
when the primary response of a reflex activates a muscle, reciprocal inhibition refers to inhibition of the antagonist muscle which occurs synchronously to the primary activation
recruitment
increase in the number of motor units involved in contraction
rectal valve
one of three transverse folds in the rectum where feces is separated from flatus
rectum
part of the large intestine between the sigmoid colon and anal canal
rectus
straight
rectus abdominis
long, linear muscle that extends along the middle of the trunk
rectus femoris
quadricep muscle on the anterior aspect of the thigh
rectus sheaths
tissue that makes up the linea alba
red blood cells (RBCs)
(also, erythrocytes) one of the formed elements of blood that transports oxygen
red bone marrow
connective tissue in the interior cavity of a bone where blood cell formation (hematopoiesis) takes place
red nucleus
midbrain nucleus that sends corrective commands to the spinal cord along the rubrospinal tract, based on disparity between an original command and the sensory feedback from movement
reduction
gaining of an electron
referred pain
the conscious perception of visceral sensation projected to a different region of the body, such as the left shoulder and arm pain as a sign for a heart attack
reflex
fast, automatic responses to stimuli that send information over a specific neural pathway
reflex arc
circuit of a reflex that involves a sensory input and motor output, or an afferent branch and an efferent branch, and an integrating center to connect the two branches
refractory period
time after the initiation of an action potential when another action potential cannot be generated
regional anatomy
study of the structures that contribute to specific body regions
Regulatory T cells (Treg)
(also, suppressor T cells) class of CD4 T cells that regulates other T cell responses
relative refractory period
time during the refractory period when a new action potential can only be initiated by a stronger stimulus than the current action potential because voltage-gated K+ channels are not closed
relaxation phase
period after twitch contraction when tension decreases
remodeling
process by which osteoclasts resorb old or damaged bone at the same time as and on the same surface where osteoblasts form new bone to replace that which is resorbed
renal artery
branch of the abdominal aorta; supplies each kidney
renal columns
extensions of the renal cortex into the renal medulla; separates the renal pyramids; contains blood vessels and connective tissues
renal corpuscle
consists of the glomerulus and Bowman’s capsule
renal cortex
outer part of kidney containing all of the nephrons; some nephrons have loops of Henle extending into the medulla
renal fat pad
adipose tissue between the renal fascia and the renal capsule that provides protective cushioning to the kidney
renal hilum
recessed medial area of the kidney through which the renal artery, renal vein, ureters, lymphatics, and nerves pass
renal medulla
inner region of kidney containing the renal pyramids
renal papillae
medullary area of the renal pyramids where collecting ducts empty urine into the minor calyces
renal pyramids
six to eight cone-shaped tissues in the medulla of the kidney containing collecting ducts and the loops of Henle of juxtamedullary nephrons
renal vein
largest vein entering the inferior vena cava; drains the kidneys and leads to the inferior vena cava
renin
enzyme produced by juxtaglomerular cells in response to decreased blood pressure or sympathetic nervous activity; catalyzes the conversion of angiotensinogen into angiotensin I
repolarization
return of the membrane potential to its normally negative voltage at the end of the action potential
reposition
movement of the thumb from opposition back to the anatomical position (next to index finger)
reserve zone
region of the epiphyseal plate that anchors the plate to the osseous tissue of the epiphysis
residual volume (RV)
amount of air that remains in the lungs after maximum exhalation
resistance (axons)
property of an axon that relates to the ability of particles to diffuse through the cytoplasm; this is inversely proportional to the fiber diameter
resistance (blood flow)
any condition or parameter that slows or counteracts the flow of blood
respiratory acidosis
condition wherein an excess of carbonic acid or CO2 causes the blood to be overly acidic
respiratory alkalosis
condition wherein a deficiency of carbonic acid/CO2 levels causes the blood to be overly alkaline
respiratory bronchiole
specific type of bronchiole that leads to alveolar sacs
respiratory cycle
one sequence of inspiration and expiration
respiratory epithelium
ciliated lining of much of the conducting zone that is specialized to remove debris and pathogens, and produce mucus
respiratory membrane
alveolar and capillary wall together, which form an air-blood barrier that facilitates the simple diffusion of gases
respiratory pump
increase in the volume of the thorax during inhalation that decreases air pressure, enabling venous blood to flow into the thoracic region, then exhalation increases pressure, moving blood into the atria
respiratory rate
total number of breaths taken each minute
respiratory volume
varying amounts of air within the lung at a given time
respiratory zone
includes structures of the respiratory system that are directly involved in gas exchange
response
nervous system function that causes a target tissue (muscle or gland) to produce an event as a consequence to stimuli
rest and digest
set of functions associated with the parasympathetic system that lead to restful actions and digestion
resting membrane potential
the difference in voltage measured across a cell membrane under steady-state conditions, typically -70 mV
reticular fiber
fine fibrous protein, made of collagen subunits, which cross-link to form supporting “nets” within connective tissue
reticular formation
diffuse region of gray matter throughout the brain stem that regulates sleep, wakefulness, and states of consciousness
reticular layer
deeper layer of the dermis; it has a reticulated appearance due to the presence of abundant collagen and elastin fibers
reticular tissue
type of loose connective tissue that provides a supportive framework to soft organs, such as lymphatic tissue, spleen, and the liver
reticulocyte
immature erythrocyte that may still contain fragments of organelles
reticuloendothelial cell
(also, Kupffer cell) phagocyte in hepatic sinusoids that filters out material from venous blood from the alimentary canal
reticulospinal tract
extrapyramidal connections between the brain stem and spinal cord that modulate movement, contribute to posture, and regulate muscle tone
retina
nervous tissue of the eye at which phototransduction takes place
retinacula
fibrous bands that sheath the tendons at the wrist
retinal
cofactor in an opsin molecule that undergoes a biochemical change when struck by a photon (pronounced with a stress on the last syllable)
retinal ganglion cell (RGC)
neuron of the retina that projects along the second cranial nerve
retraction
posterior motion of the scapula or mandible
retrograde amnesia
loss of memories before a particular event
retroperitoneal
located outside the peritoneal cavity, between the parietal peritoneum and the abdominal wall
Rh blood group
blood-type classification based on the presence or absence of the antigen Rh on the erythrocyte membrane surface
rhodopsin
photopigment molecule found in the rod photoreceptors
rhombencephalon
primary vesicle of the embryonic brain that develops into the hindbrain, which includes the pons, cerebellum, and medulla
rhomboid major
muscle that attaches the vertebral border of the scapula to the spinous process of the thoracic vertebrae
rhomboid minor
muscle that attaches the vertebral border of the scapula to the spinous process of the thoracic vertebrae
ribonuclease
pancreatic enzyme that digests RNA
ribonucleic acid (RNA)
ribose-containing nucleotide that helps manifest the genetic code as protein
ribosomal RNA (rRNA)
RNA that makes up the subunits of a ribosome
ribosome
cellular organelle that functions in protein synthesis
ribs
thin, curved bones of the chest wall
rickets
disease in children caused by vitamin D deficiency, which leads to the weakening of bones
right atrioventricular valve
(also, tricuspid valve) valve located between the right atrium and ventricle; consists of three flaps of tissue
right colic flexure
(also, hepatic flexure) point, at the inferior surface of the liver, where the ascending colon turns abruptly to the left
right gastric artery
branch of the common hepatic artery; supplies blood to the stomach
right lymphatic duct
drains lymph fluid from the upper right side of body into the right subclavian vein
Rinne test
use of a tuning fork to test conductive hearing loss versus sensorineural hearing loss
rod photoreceptor
one of the two types of retinal receptor cell that is specialized for low-light vision
Romberg test
test of equilibrium that requires the patient to maintain a straight, upright posture without visual feedback of position
root of the nose
region of the external nose between the eyebrows
root of the teeth
portion of a tooth embedded in the alveolar processes beneath the gum line
rotation
movement of a bone around a central axis (atlantoaxial joint) or around its long axis (proximal radioulnar joint; shoulder or hip joint); twisting of the vertebral column resulting from the summation of small motions between adjacent vertebrae
rotator cuff
strong connective tissue structure formed by the fusion of four rotator cuff muscle tendons to the articular capsule of the shoulder joint; surrounds and supports superior, anterior, lateral, and posterior sides of the humeral head
round window
membrane that marks the end of the scala tympani
rubrospinal tract
descending motor control pathway, originating in the red nucleus, that mediates control of the limbs on the basis of cerebellar processing
ruga
fold of alimentary canal mucosa and submucosa in the empty stomach and other organs
rugae
(of the vagina) folds of skin in the vagina that allow it to stretch during intercourse and childbirth

S

S phase
stage of the cell cycle during which DNA replication occurs
saccade
small, rapid movement of the eyes used to locate and direct the fovea onto visual stimuli
saccharolytic fermentation
anaerobic decomposition of carbohydrates
saccule
structure of the inner ear responsible for transducing linear acceleration in the vertical plane
sacral canal
bony tunnel that runs through the sacrum
sacral foramina
series of paired openings for nerve exit located on both the anterior (ventral) and posterior (dorsal) aspects of the sacrum
sacral hiatus
inferior opening and termination of the sacral canal
sacral micturition center
group of neurons in the sacral region of the spinal cord that controls urination; acts reflexively unless its action is modified by higher brain centers to allow voluntary urination
sacral plexus
nerve plexus associated with the lower lumbar and sacral spinal nerves
sacral promontory
anterior lip of the base (superior end) of the sacrum
sacrococcygeal curvature
anteriorly concave curvature formed by the sacrum and coccyx; a primary curve of the vertebral column
sacroiliac joint
joint formed by the articulation between the auricular surfaces of the sacrum and ilium
sacrospinous ligament
ligament that spans the sacrum to the ischial spine of the hip bone
sacrotuberous ligament
ligament that spans the sacrum to the ischial tuberosity of the hip bone
sacrum
single bone located near the inferior end of the adult vertebral column that is formed by the fusion of five sacral vertebrae; forms the posterior portion of the pelvis
saddle joint
synovial joint in which the articulating ends of both bones are convex and concave in shape, such as at the first carpometacarpal joint at the base of the thumb; functionally classified as a biaxial joint
sagittal plane
two-dimensional, vertical plane that divides the body or organ into right and left sides
sagittal suture
joint that unites the right and left parietal bones at the midline along the top of the skull
saliva
aqueous solution of proteins and ions secreted into the mouth by the salivary glands
salivary amylase
digestive enzyme found in the saliva which begins the digestion of complex carbohydrates in the mouth
salivary gland
an exocrine gland that secretes a digestive fluid called saliva
salivation
secretion of saliva
saltatory conduction
quick propagation of the action potential along a myelinated axon owing to voltage-gated Na+ channels being present only at the nodes of Ranvier
saphenous nerve
systemic nerve of the lower anterior leg that is a branch from the femoral nerve
sarcolemma
plasma membrane of a skeletal muscle fiber
sarcomere
longitudinally, repeating functional unit of skeletal muscle, with all of the contractile and associated proteins involved in contraction
sarcopenia
age-related muscle atrophy
sarcoplasm
cytoplasm of a muscle cell
sarcoplasmic reticulum (SR)
specialized smooth endoplasmic reticulum, which stores, releases, and retrieves Ca++
sartorius
band-like muscle that flexes, abducts, and laterally rotates the leg at the hip
satellite cell (stem cell)
stem cell that helps to repair muscle cells
satellite cell of the PNS
glial cell type in the PNS that provides support for neurons in the ganglia
scala tympani
portion of the cochlea that extends from the apex to the round window
scala vestibuli
portion of the cochlea that extends from the oval window to the apex
scalene muscles
flex, laterally flex, and rotate the head; contribute to deep inhalation
scaphoid
from the lateral side, the first of the four proximal carpal bones; articulates with the radius proximally, the trapezoid, trapezium, and capitate distally, and the lunate medially
scapula
shoulder blade bone located on the posterior side of the shoulder
scar
collagen-rich skin formed after the process of wound healing that is different from normal skin
Schwann cell
glial cell type in the PNS that provides the myelin insulation for axons in nerves
sciatic nerve
systemic nerve from the sacral plexus that is a combination of the tibial and fibular nerves and extends across the hip joint and gluteal region into the upper posterior leg
sciatica
painful condition resulting from inflammation or compression of the sciatic nerve or any of the spinal nerves that contribute to it
sclera
white of the eye
sclerotome
medial portion of a somite consisting of mesenchyme tissue that will give rise to bone, cartilage, and fibrous connective tissues
scoliosis
abnormal lateral curvature of the vertebral column
scrotum
external pouch of skin and muscle that houses the testes
sebaceous gland
type of oil gland found in the dermis all over the body and helps to lubricate and waterproof the skin and hair by secreting sebum
sebum
oily substance that is composed of a mixture of lipids that lubricates the skin and hair
second messenger
molecule that initiates a signaling cascade in response to hormone binding on a cell membrane receptor and activation of a G protein
second-degree burn
partial-thickness burn that injures the epidermis and a portion of the dermis
secondary adaptive response
immune response observed upon re-exposure to a pathogen, which is stronger and faster than a primary response
secondary curvature
posteriorly concave curvatures of the cervical and lumbar regions of the vertebral column that develop after the time of birth
secondary follicles
ovarian follicles with a primary oocyte and multiple layers of granulosa cells
secondary lymphoid organs
sites where lymphocytes mount adaptive immune responses; examples include lymph nodes and spleen
secondary ossification center
region of endochondral bone development in the epiphyses
secondary sex characteristics
physical characteristics that are influenced by sex steroid hormones and have supporting roles in reproductive function
secondary union
wound healing facilitated by wound contraction
secondary vesicle
five vesicles that develop from primary vesicles, continuing the process of differentiation of the embryonic brain
secretin
hormone released in the small intestine to aid in digestion
secretory phase
phase of the menstrual cycle in which the endometrium secretes a nutrient-rich fluid in preparation for implantation of an embryo
section
in anatomy, a single flat surface of a three-dimensional structure that has been cut through
segmental muscle group
interspinales and intertransversarii muscles that bring together the spinous and transverse processes of each consecutive vertebra
segmentation
alternating contractions and relaxations of non-adjacent segments of the intestine that move food forward and backward, breaking it apart and mixing it with digestive juices
selective permeability
feature of any barrier that allows certain substances to cross but excludes others
sella turcica
elevated area of sphenoid bone located at midline of the middle cranial fossa
semen
ejaculatory fluid composed of sperm and secretions from the seminal vesicles, prostate, and bulbourethral glands
semicircular canals
structures within the inner ear responsible for transducing rotational movement information
semilunar valves
valves located at the base of the pulmonary trunk and at the base of the aorta
semimembranosus
hamstring muscle
seminal vesicle
gland that produces seminal fluid, which contributes to semen
seminiferous tubules
tube structures within the testes where spermatogenesis occurs
semispinalis capitis
transversospinales muscle associated with the head region
semispinalis cervicis
transversospinales muscle associated with the cervical region
semispinalis thoracis
transversospinales muscle associated with the thoracic region
semitendinosus
hamstring muscle
sensation
nervous system function that receives information from the environment and translates it into the electrical signals of nervous tissue
sensitization
first exposure to an antigen
sensor
(also, receptor) reports a monitored physiological value to the control center
sensorineural hearing
hearing dependent on the transduction and propagation of auditory information through the neural components of the peripheral auditory structures
sensory homunculus
topographic representation of the body within the somatosensory cortex demonstrating the correspondence between neurons processing stimuli and sensitivity
sensory modality
a particular system for interpreting and perceiving environmental stimuli by the nervous system
sepsis
(also, septicemia) organismal-level inflammatory response to a massive infection
septal cartilage
flat cartilage structure that forms the anterior portion of the nasal septum
septic shock
(also, blood poisoning) type of shock that follows a massive infection resulting in organism-wide inflammation
septum
(plural = septa) walls or partitions that divide the heart into chambers
septum primum
flap of tissue in the fetus that covers the foramen ovale within a few seconds after birth
seroconversion
clearance of pathogen in the serum and the simultaneous rise of serum antibody
serosa
outermost layer of the alimentary canal wall present in regions within the abdominal cavity
serous gland
group of cells within the serous membrane that secrete a lubricating substance onto the surface
serous membrane
type of tissue membrane that lines body cavities and lubricates them with serous fluid
serratus anterior
large and flat muscle that originates on the ribs and inserts onto the scapula
Sertoli cells
cells that support germ cells through the process of spermatogenesis; a type of sustentacular cell
serum
blood plasma that does not contain clotting factors
sesamoid bone
small, round bone embedded in a tendon; protects the tendon from compressive forces
set point
ideal value for a physiological parameter; the level or small range within which a physiological parameter such as blood pressure is stable and optimally healthful, that is, within its parameters of homeostasis
severe combined immunodeficiency disease (SCID)
genetic mutation that affects both T cell and B cell arms of the immune response
sex chromosomes
pair of chromosomes involved in sex determination; in males, the XY chromosomes; in females, the XX chromosomes
shaft of the femur
cylindrically shaped region that forms the central portion of the femur
shaft of the fibula
elongated, slender portion located between the expanded ends of the fibula
shaft of the humerus
narrow, elongated, central region of the humerus
shaft of the radius
narrow, elongated, central region of the radius
shaft of the tibia
triangular-shaped, central portion of the tibia
shaft of the ulna
narrow, elongated, central region of the ulna
short bone
cube-shaped bone that is approximately equal in length, width, and thickness; provides limited motion
short reflex
reflex arc that does not include any components of the central nervous system
short-term memory
capacity to retain information actively in the brain for a brief period of time
shunt
circulatory shortcut that diverts the flow of blood from one region to another
sickle cell disease
(also, sickle cell anemia) inherited blood disorder in which hemoglobin molecules are malformed, leading to the breakdown of RBCs that take on a characteristic sickle shape
sigmoid colon
end portion of the colon, which terminates at the rectum
sigmoid sinuses
dural sinuses that drain blood from the transverse sinuses into the internal jugular vein
simple columnar epithelium
tissue that consists of a single layer of column-like cells; promotes secretion and absorption in tissues and organs
simple cuboidal epithelium
tissue that consists of a single layer of cube-shaped cells; promotes secretion and absorption in ducts and tubules
simple diffusion
mechanism of molecules moving across a cell membrane from the side where they are more concentrated to the side where they are less concentrated is a form of passive transport
simple squamous epithelium
tissue that consists of a single layer of flat scale-like cells; promotes diffusion and filtration across surface
sinoatrial (SA) node
known as the pacemaker, a specialized clump of myocardial conducting cells located in the superior portion of the right atrium that has the highest inherent rate of depolarization that then spreads throughout the heart
sinus rhythm
normal contractile pattern of the heart
sinus venosus
develops into the posterior portion of the right atrium, the SA node, and the coronary sinus
sinusoid capillary
rarest type of capillary, which has extremely large intercellular gaps in the basement membrane in addition to clefts and fenestrations; found in areas such as the bone marrow and liver where passage of large molecules occurs
sister chromatid
one of a pair of identical chromosomes, formed during DNA replication
skeletal muscle
striated, multinucleated muscle that requires signaling from the nervous system to trigger contraction; most skeletal muscles are referred to as voluntary muscles that move bones and produce movement
skeletal muscle pump
effect on increasing blood pressure within veins by compression of the vessel caused by the contraction of nearby skeletal muscle
skeletal system
organ system composed of bones, cartilage and ligaments that provides for movement, support, protection, mineral and fat storage, blood cells formation
skeleton
bones of the body
skull
bony structure that forms the head, face, and jaws, and protects the brain; consists of 22 bones
slow oxidative fiber
muscle fiber that primarily uses aerobic respiration
small cardiac vein
parallels the right coronary artery and drains blood from the posterior surfaces of the right atrium and ventricle; drains into the great cardiac vein
small intestine
section of the alimentary canal where most digestion and absorption occurs
small saphenous vein
located on the lateral surface of the leg; drains blood from the superficial regions of the lower leg and foot, and leads to the popliteal vein
smooth muscle
nonstriated, mononucleated muscle in the skin that is associated with hair follicles; assists in moving materials in the walls of internal organs, blood vessels, and internal passageways
Snellen chart
standardized arrangement of letters in decreasing size presented to a subject at a distance of 20 feet to test visual acuity
sodium bicarbonate
anion released into the small intestine to neutralize the pH of the food from the stomach
sodium-potassium pump
(also, Na+/K+ ATP-ase) membrane-embedded protein pump that uses ATP to move Na+ out of a cell and K+ into the cell
soft palate
posterior region of the bottom portion of the nasal cavity that consists of skeletal muscle
soleal line
small, diagonally running ridge located on the posterior side of the proximal tibia
soleus
wide, flat muscle deep to the gastrocnemius
solitary nucleus
medullar nucleus that receives taste information from the facial and glossopharyngeal nerves
solution
homogeneous liquid mixture in which a solute is dissolved into molecules within a solvent
soma (cell body)
in neurons, that portion of the cell that contains the nucleus
somatic cell
all cells of the body excluding gamete cells
somatic reflex
reflex involving skeletal muscle as the effector, under the control of the somatic nervous system
somatosensation
general senses related to the body, usually thought of as the senses of touch, which would include pain, temperature, and proprioception
somite
one of the paired, repeating blocks of tissue located on either side of the notochord in the early embryo
somites
blocks of paraxial mesoderm cells
spasticity
increased contraction of a muscle in response to resistance, often resulting in hyperflexia
spatial summation
combination of graded potentials across the neuronal cell membrane caused by signals from separate presynaptic elements that add up to initiate an action potential
special sense
any sensory system associated with a specific organ structure, namely smell, taste, sight, hearing, and balance
speed lever
the load arm is longer than the effort arm
sperm
(also, spermatozoon) male gamete
spermatic cord
bundle of nerves and blood vessels that supplies the testes; contains ductus deferens
spermatid
immature sperm cells produced by meiosis II of secondary spermatocytes
spermatocyte
cell that results from the division of spermatogonium and undergoes meiosis I and meiosis II to form spermatids
spermatogenesis
formation of new sperm, occurs in the seminiferous tubules of the testes
spermatogonia
(singular = spermatogonium) diploid precursor cells that become sperm
spermiogenesis
transformation of spermatids to spermatozoa during spermatogenesis
sphenoid bone
unpaired bone that forms the central base of skull
sphenoid sinus
air-filled space located within the sphenoid bone; most posterior of the paranasal sinuses
sphincter urethrovaginalis
deep perineal muscle in women
sphygmomanometer
blood pressure cuff attached to a device that measures blood pressure
spinal accessory nerve
eleventh cranial nerve; responsible for contraction of neck muscles
spinal cord
organ of the central nervous system found within the vertebral cavity and connected with the periphery through spinal nerves; mediates reflex behaviors
spinal nerve
one of 31 nerves connected to the spinal cord
spinal trigeminal nucleus
component of the trigeminal nuclei that is found in the medulla
spinalis capitis
muscle of the spinalis group associated with the head region
spinalis cervicis
muscle of the spinalis group associated with the cervical region
spinalis group
medially placed muscles of the erector spinae
spinalis thoracis
muscle of the spinalis group associated with the thoracic region
spine of the scapula
prominent ridge passing mediolaterally across the upper portion of the posterior scapular surface
spinocerebellar tract
ascending fibers that carry proprioceptive input to the cerebellum used in maintaining balance and coordinated movement
spinocerebellum
midline region of the cerebellum known as the vermis that receives proprioceptive input from the spinal cord
spinothalamic tract
ascending tract of the spinal cord associated with pain and temperature sensations
spinous process
unpaired bony process that extends posteriorly from the vertebral arch of a vertebra
spiral ganglia
location of neuronal cell bodies that transmit auditory information along the eighth cranial nerve
spleen
secondary lymphoid organ that filters pathogens from the blood (white pulp) and removes degenerating or damaged blood cells (red pulp)
splenic artery
branch of the celiac trunk; supplies blood to the spleen
splenius
posterior neck muscles; includes the splenius capitis and splenius cervicis
splenius capitis
neck muscle that inserts into the head region
splenius cervicis
neck muscle that inserts into the cervical region
spliceosome
complex of enzymes that serves to splice out the introns of a pre-mRNA transcript
splicing
the process of modifying a pre-mRNA transcript by removing certain, typically non-coding, regions
spongy bone
(also, cancellous bone) trabeculated osseous tissue that supports shifts in weight distribution
spontaneous depolarization
(also, prepotential depolarization) the mechanism that accounts for the autorhythmic property of cardiac muscle; the membrane potential increases as sodium ions diffuse through the always-open sodium ion channels and causes the electrical potential to rise
squamous cell carcinoma
type of skin cancer that originates from the stratum spinosum of the epidermis
squamous suture
joint that unites the parietal bone to the squamous portion of the temporal bone on the lateral side of the skull
stage of exhaustion
stage three of the general adaptation syndrome; the body’s long-term response to stress mediated by the hormones of the adrenal cortex
stage of resistance
stage two of the general adaptation syndrome; the body’s continued response to stress after stage one diminishes
stapes
(also, stirrup) ossicle of the middle ear that is attached to the inner ear
stem cell
cell that is oligo-, multi-, or pleuripotent that has the ability to produce additional stem cells rather than becoming further specialized
stereocilia
array of apical membrane extensions in a hair cell that transduce movements when they are bent
stereognosis
perception of common objects placed in the hand solely on the basis of manipulation of that object in the hand
sternal angle
junction line between manubrium and body of the sternum and the site for attachment of the second rib to the sternum
sternal end of the clavicle
medial end of the clavicle that articulates with the manubrium of the sternum
sternoclavicular joint
articulation between the manubrium of the sternum and the sternal end of the clavicle; forms the only bony attachment between the pectoral girdle of the upper limb and the axial skeleton
sternocleidomastoid
major muscle that laterally flexes and rotates the head
sternohyoid
muscle that depresses the hyoid bone
sternothyroid
muscle that depresses the larynx’s thyroid cartilage
sternum
flattened bone located at the center of the anterior chest
steroid
(also, sterol) lipid compound composed of four hydrocarbon rings bonded to a variety of other atoms and molecules
stimulus
an event in the external or internal environment that registers as activity in a sensory neuron
stomach
alimentary canal organ that contributes to chemical and mechanical digestion of food from the esophagus before releasing it, as chyme, to the small intestine
straight sinus
a dural sinus that drains blood from the deep center of the brain into the left or right transverse sinus
stratified columnar epithelium
tissue that consists of two or more layers of column-like cells, contains glands and is found in some ducts
stratified cuboidal epithelium
tissue that consists of two or more layers of cube-shaped cells, found in some ducts
stratified squamous epithelium
tissue that consists of multiple layers of cells with the most apical being flat scale-like cells; protects surfaces from abrasion
stratum basale
deepest layer of the epidermis, made of epidermal stem cells
stratum corneum
most superficial layer of the epidermis
stratum granulosum
layer of the epidermis superficial to the stratum spinosum
stratum lucidum
layer of the epidermis between the stratum granulosum and stratum corneum, found only in thick skin covering the palms, soles of the feet, and digits
stratum spinosum
layer of the epidermis superficial to the stratum basale, characterized by the presence of desmosomes
stretch mark
mark formed on the skin due to a sudden growth spurt and expansion of the dermis beyond its elastic limits
stretch reflex
response to activation of the muscle spindle stretch receptor that causes contraction of the muscle to maintain a constant length
striation
alignment of parallel actin and myosin filaments which form a banded pattern
striatum
the caudate and putamen collectively, as part of the basal nuclei, which receive input from the cerebral cortex
stroke
(also, cerebrovascular accident (CVA)) loss of neurological function caused by an interruption of blood flow to a region of the central nervous system
stroke volume
the volume of blood pumped by one ventricle
stroke volume (SV)
amount of blood pumped by each ventricle per contraction; also, the difference between EDV and ESV
styloglossus
muscle that originates on the styloid bone, and allows upward and backward motion of the tongue
stylohyoid
muscle that elevates the hyoid bone posteriorly
styloid process
downward projecting, elongated bony process located on the inferior aspect of the skull
styloid process of the radius
pointed projection located on the lateral end of the distal radius
styloid process of the ulna
short, bony projection located on the medial end of the distal ulna
stylomastoid foramen
opening located on inferior skull, between the styloid process and mastoid process
subacromial bursa
bursa that protects the supraspinatus muscle tendon and superior end of the humerus from rubbing against the acromion of the scapula
subarachnoid space
space between the arachnoid mater and pia mater that contains CSF and the fibrous connections of the arachnoid trabeculae
subclavian artery
right subclavian arises from the brachiocephalic artery, whereas the left subclavian artery arises from the aortic arch; gives rise to the internal thoracic, vertebral, and thyrocervical arteries; supplies blood to the arms, chest, shoulders, back, and central nervous system
subclavian vein
located deep in the thoracic cavity; becomes the axillary vein as it enters the axillary region; drains the axillary and smaller local veins near the scapular region; leads to the brachiocephalic vein
subclavius
muscle that stabilizes the clavicle during movement
subcortical nuclei
all the nuclei beneath the cerebral cortex, including the basal nuclei and the basal forebrain
subcutaneous bursa
bursa that prevents friction between skin and an underlying bone
sublingual gland
one of a pair of major salivary glands located beneath the tongue
submandibular gland
one of a pair of major salivary glands located in the floor of the mouth
submodality
specific sense within a broader major sense such as sweet as a part of the sense of taste, or color as a part of vision
submucosa
layer of dense connective tissue in the alimentary canal wall that binds the overlying mucosa to the underlying muscularis
submucosal plexus
(plexus of Meissner) nerve supply that regulates activity of glands and smooth muscle
submuscular bursa
bursa that prevents friction between bone and a muscle or between adjacent muscles
subpubic angle
inverted V-shape formed by the convergence of the right and left ischiopubic rami; this angle is greater than 80 degrees in females and less than 70 degrees in males
subscapular bursa
bursa that prevents rubbing of the subscapularis muscle tendon against the scapula
subscapular fossa
broad depression located on the anterior (deep) surface of the scapula
subscapular vein
drains blood from the subscapular region and leads to the axillary vein
subscapularis
muscle that originates on the anterior scapula and medially rotates the arm
substantia nigra pars compacta
nuclei within the basal nuclei that release dopamine to modulate the function of the striatum; part of the motor pathway
substantia nigra pars reticulata
nuclei within the basal nuclei that serve as an output center of the nuclei; part of the motor pathway
substrate
reactant in an enzymatic reaction
subtalar joint
articulation between the talus and calcaneus bones of the foot; allows motions that contribute to inversion/eversion of the foot
subtendinous bursa
bursa that prevents friction between bone and a muscle tendon
subthalamus
nucleus within the basal nuclei that is part of the indirect pathway
sucrase
brush border enzyme that breaks down sucrose into glucose and fructose
sudoriferous glands
sweat gland
sulcus of the cerebral cortex
groove formed by convolutions in the surface of the cerebral cortex
sulcus of the heart
(plural = sulci) fat-filled groove visible on the surface of the heart; coronary vessels are also located in these areas
summate
to add together, as in the cumulative change in postsynaptic potentials toward reaching threshold in the membrane, either across a span of the membrane or over a certain amount of time
superficial
describes a position nearer to the surface of the body
superficial anterior compartment of the forearm
flexor carpi radialis, palmaris longus, flexor carpi ulnaris, flexor digitorum superficialis, and their associated blood vessels and nerves
superficial posterior compartment of the forearm
extensor radialis longus, extensor carpi radialis brevis, extensor digitorum, extensor digiti minimi, extensor carpi ulnaris, and their associated blood vessels and nerves
superficial reflex
reflexive contraction initiated by gentle stimulation of the skin
superior
describes a position above or higher than another part of the body proper; also referred to as cranial
superior angle of the scapula
corner of the scapula between the superior and medial borders of the scapula
superior articular process
bony process that extends upward from the vertebral arch of a vertebra that articulates with the inferior articular process of the next higher vertebra
superior articular process of the sacrum
paired processes that extend upward from the sacrum to articulate (join) with the inferior articular processes from the L5 vertebra
superior border of the scapula
superior margin of the scapula
superior cerebellar peduncle (SCP)
white-matter tract representing output of the cerebellum to the red nucleus of the midbrain
superior cervical ganglion
one of the paravertebral ganglia of the sympathetic system that projects to the head
superior colliculus
structure in the midbrain that combines visual, auditory, and somatosensory input to coordinate spatial and topographic representations of the three sensory systems
superior extensor retinaculum
transverse ligament of the ankle
superior gemellus
muscle deep to the gluteus maximus on the lateral surface of the thigh that laterally rotates the femur at the hip
superior mesenteric artery
branch of the abdominal aorta; supplies blood to the small intestine (duodenum, jejunum, and ileum), the pancreas, and a majority of the large intestine
superior mesenteric ganglion
one of the collateral ganglia of the sympathetic system that projects to the digestive system
superior nasal concha
smallest and most superiorly located of the nasal conchae; formed by the ethmoid bone
superior nuchal line
paired bony lines on the posterior skull that extend laterally from the external occipital protuberance
superior oblique
extraocular muscle responsible for medial rotation of the eye
superior orbital fissure
irregularly shaped opening between the middle cranial fossa and the posterior orbit
superior phrenic artery
branch of the thoracic aorta; supplies blood to the superior surface of the diaphragm
superior pubic ramus
narrow segment of bone that passes laterally from the pubic body to join the ilium
superior rectus
extraocular muscle responsible for looking up
superior rotation
movement of the scapula during upper limb abduction in which the glenoid cavity of the scapula moves in an upward direction as the medial end of the scapular spine moves in a downward direction
superior sagittal sinus
a dural sinus located midsagittally between the meningeal and periosteal layers of the dura mater within the falx cerebri that drains blood from the majority of the outer cerebrum into the inferior jugular and vertebral veins.
superior vena cava
large systemic vein that returns blood to the heart from areas superior to the diaphragm
supinated position
forearm position in which the palm faces anteriorly (anatomical position)
supination
forearm motion that moves the palm of the hand from the palm backward to the palm forward position
supinator
muscle that moves the palm and forearm anteriorly
supplemental motor area
cortical area anterior to the primary motor cortex that is responsible for planning movements
supportive connective tissue
type of connective tissue that provides strength to the body and protects soft tissue
suprachiasmatic nucleus
hypothalamic target of the retina that helps to establish the circadian rhythm of the body on the basis of the presence or absence of daylight
supraglenoid tubercle
small bump located at the superior margin of the glenoid cavity
suprahyoid muscles
neck muscles that are superior to the hyoid bone
supraorbital foramen
opening located on anterior skull, at the superior margin of the orbit
supraorbital margin
superior margin of the orbit
suprascapular notch
small notch located along the superior border of the scapula, medial to the coracoid process
supraspinatus
muscle that abducts the arm
supraspinous fossa
narrow depression located on the posterior scapula, superior to the spine
supraspinous ligament
ligament that interconnects the spinous processes of the thoracic and lumbar vertebrae
surgical neck
region of the humerus where the expanded, proximal end joins with the narrower shaft
suspension
liquid mixture in which particles distributed in the liquid settle out over time
suspensory ligaments
bands of connective tissue that suspend the breast onto the chest wall by attachment to the overlying dermis
sustentaculum tali
bony ledge extending from the medial side of the calcaneus bone
suture
fibrous, synarthrotic joint that connects bones of the skull (except the mandible)
sympathetic chain ganglia
series of ganglia adjacent to the vertebral column that receive input from central sympathetic neurons
sympathetic division
division of the autonomic nervous system associated with the fight-or-flight response
sympatholytic drug
drug that interrupts, or “lyses,” the function of the sympathetic system
sympathomimetic drug
drug that enhances or mimics the function of the sympathetic system
symphysis
type of cartilaginous joint where the bones are joined by fibrocartilage
synapse
site of communication between a neuron and another cell
synaptic cleft
small gap between cells in a chemical synapse where neurotransmitter diffuses from the presynaptic cell to the postsynaptic cell
synaptic end bulb
swelling at the end of an axon where neurotransmitter molecules are released onto a target cell across a synapse
synarthrosis
immobile or nearly immobile joint
synchondrosis
type of cartilaginous joint where the bones are joined by hyaline cartilage
syncytiotrophoblast
superficial cells of the trophoblast that fuse to form a multinucleated body that digests endometrial cells to firmly secure the blastocyst to the uterine wall
syndesmosis
type of fibrous joint in which two separated, parallel bones are connected by an interosseous membrane
synergist
muscle whose contraction helps a prime mover in an action
synostosis
site at which adjacent bones or bony components have fused together
synovial fluid
thick, lubricating fluid that fills the interior of a synovial joint
synovial joint
joint at which the articulating surfaces of the bones are located within a joint cavity formed by an articular capsule
synovial membrane
thin layer of connective tissue membrane that lines the cavities of synovial joints, producing synovial fluid for lubrication
synthesis reaction
type of anabolic reaction in which two or more atoms or molecules bond, resulting in the formation of a larger molecule
systemic anatomy
study of the structures that contribute to specific body systems
systemic circuit
blood flow to and from virtually all of the tissues of the body
systemic nerve
nerve in the periphery distal to a nerve plexus or spinal nerve
systole
period of time when the heart muscle is contracting
systolic pressure
larger number recorded when measuring arterial blood pressure; represents the maximum value following ventricular contraction

T

T cell
lymphocyte that acts by secreting molecules that regulate the immune system or by causing the destruction of foreign cells, viruses, and cancer cells
T cell tolerance
process during T cell differentiation where most T cells that recognize antigens from one’s own body are destroyed
T cell-dependent antigen
antigen that binds to B cells, which requires signals from T cells to make antibody
T cell-independent antigen
binds to B cells, which do not require signals from T cells to make antibody
T lymphocytes
(also, T cells) lymphocytes that provide cellular-level immunity by physically attacking foreign or diseased cells
T wave
component of the electrocardiogram that represents the repolarization of the ventricles
T-tubule
projection of the sarcolemma into the interior of the cell
talocrural joint
ankle joint; articulation between the talus bone of the foot and medial malleolus of the tibia, distal tibia, and lateral malleolus of the fibula; a uniaxial hinge joint that allows only for dorsiflexion and plantar flexion of the foot
talus
tarsal bone that articulates superiorly with the tibia and fibula at the ankle joint; also articulates inferiorly with the calcaneus bone and anteriorly with the navicular bone
target effector
organ, tissue, or gland that will respond to the control of an autonomic or somatic or endocrine signal
target heart rate
range in which both the heart and lungs receive the maximum benefit from an aerobic workout
tarsal bone
one of the seven bones that make up the posterior foot; includes the calcaneus, talus, navicular, cuboid, medial cuneiform, intermediate cuneiform, and lateral cuneiform bones
taste buds
structures within a papilla on the tongue that contain gustatory receptor cells
tectorial membrane
component of the organ of Corti that lays over the hair cells, into which the stereocilia are embedded
tectospinal tract
extrapyramidal connections between the superior colliculus and spinal cord
tectum
region of the midbrain, thought of as the roof of the cerebral aqueduct, which is subdivided into the inferior and superior colliculi
tegmentum
region of the midbrain, thought of as the floor of the cerebral aqueduct, which continues into the pons and medulla as the floor of the fourth ventricle
telencephalon
secondary vesicle of the embryonic brain that develops into the cerebrum
telogen
resting phase of the hair growth cycle initiated with catagen and terminated by the beginning of a new anagen phase of hair growth
telophase
final stage of mitosis (and meiosis), preceding cytokinesis, characterized by the formation of two new daughter nuclei
temporal bone
paired bones that form the lateral, inferior portions of the skull, with squamous, mastoid, and petrous portions
temporal fossa
shallow space on the lateral side of the skull, above the level of the zygomatic arch
temporal lobe
region of the cerebral cortex directly beneath the temporal bone of the cranium
temporal process of the zygomatic bone
short extension from the zygomatic bone that forms the anterior portion of the zygomatic arch
temporal summation
combination of graded potentials at the same location on a neuron resulting in a strong signal from one input
temporal vein
drains blood from the temporal region and leads to the external jugular vein
temporalis
muscle that retracts the mandible
temporomandibular joint (TMJ)
articulation between the condyle of the mandible and the mandibular fossa and articular tubercle of the temporal bone of the skull; allows for depression/elevation (opening/closing of mouth), protraction/retraction, and side-to-side motions of the mandible
tendinous intersections
three transverse bands of collagen fibers that divide the rectus abdominis into segments
tendon
dense connective tissue structure that anchors a muscle to bone
tendon sheath
connective tissue that surrounds a tendon at places where the tendon crosses a joint; contains a lubricating fluid to prevent friction and allow smooth movements of the tendon
tendons
a dense connective tissue that connect bones to muscles
tenia coli
one of three smooth muscle bands that make up the longitudinal muscle layer of the muscularis in all of the large intestine except the terminal end
tensor fascia latae
muscle that flexes and abducts the thigh
teres major
muscle that extends the arm and assists in adduction and medial rotation of it
teres minor
muscle that laterally rotates and extends the arm
terminal electron acceptor
oxygen, the recipient of the free hydrogen at the end of the electron transport chain
terminal ganglia
ganglia of the parasympathetic division of the autonomic system, which are located near or within the target effector, the latter also known as intramural ganglia
tertiary follicles
(also, antral follicles) ovarian follicles with a primary or secondary oocyte, multiple layers of granulosa cells, and a fully formed antrum
testes
(singular = testis) male gonads
testicular artery
branch of the abdominal aorta; will ultimately travel outside the body cavity to the testes and form one component of the spermatic cord
testicular vein
drains the testes and forms part of the spermatic cord; the right testicular vein empties directly into the inferior vena cava and the left testicular vein empties into the left renal vein
testosterone
steroid hormone secreted by the male testes and important in the maturation of sperm cells, growth and development of the male reproductive system, and the development of male secondary sex characteristics
Th1 cells
cells that secrete cytokines that enhance the activity of macrophages and other cells
Th2 cells
cells that secrete cytokines that induce B cells to differentiate into antibody-secreting plasma cells
thalamus
major region of the diencephalon that is responsible for relaying sensory information between the cerebrum and the hindbrain, spinal cord, and periphery
thalassemia
inherited blood disorder in which maturation of RBCs does not proceed normally, leading to abnormal formation of hemoglobin and the destruction of RBCs
theca cells
estrogen-producing cells in a maturing ovarian follicle
thenar
group of muscles on the lateral aspect of the palm
thenar eminence
rounded contour of muscle at the base of the thumb
thermoneutral
external temperature at which the body does not expend any energy for thermoregulation, about 84 °F
thermoreceptor
type of sensory receptor stimulated by changes in temperature
thermoregulation
process of regulating the temperature of the body
thick filament
the thick myosin strands and their multiple heads projecting from the center of the sarcomere toward, but not all to way to, the Z-discs
thigh
portion of the lower limb located between the hip and knee joints
thin filament
thin strands of actin and its troponin-tropomyosin complex projecting from the Z-discs toward the center of the sarcomere
third ventricle
portion of the ventricular system that is in the region of the diencephalon
third-degree burn
burn that penetrates and destroys the full thickness of the skin (epidermis and dermis)
thoracic aorta
portion of the descending aorta superior to the aortic hiatus
thoracic cage
consists of 12 pairs of ribs and sternum
thoracic cavity
division of the anterior (ventral) cavity that houses the heart, lungs, esophagus, and trachea
thoracic curvature
anteriorly concave curvature of the thoracic vertebral column region; a primary curve of the vertebral column
thoracic duct
large duct that drains lymph from the lower limbs, left thorax, left upper limb, and the left side of the head
thoracic vertebrae
twelve vertebrae numbered as T1–T12 that are located in the thoracic region (upper back) of the vertebral column
thoracic wall compliance
ability of the thoracic wall to stretch while under pressure
thoracolumbar system
alternate name for the sympathetic division of the autonomic nervous system that is based on the anatomical location of central neurons in the lateral horn of the thoracic and upper lumbar spinal cord
thoroughfare channel
continuation of the metarteriole that enables blood to bypass a capillary bed and flow directly into a venule, creating a vascular shunt
threshold
membrane voltage at which an action potential is initiated
thrombin
enzyme essential for the final steps in formation of a fibrin clot
thrombocytes
platelets, one of the formed elements of blood that consists of cell fragments broken off from megakaryocytes
thrombocytopenia
condition in which there are too few platelets, resulting in abnormal bleeding (hemophilia)
thrombocytosis
condition in which there are too many platelets, resulting in abnormal clotting (thrombosis)
thrombopoietin
hormone secreted by the liver and kidneys that prompts the development of megakaryocytes into thrombocytes (platelets)
thrombosis
excessive clot formation
thrombus
aggregation of fibrin, platelets, and erythrocytes in an intact artery or vein
thymocyte
immature T cell found in the thymus
thymosins
hormones produced and secreted by the thymus that play an important role in the development and differentiation of T cells
thymus
primary lymphoid organ; involved in the development and maturation of T-cells (T lymphocytes) and is particularly active during infancy and childhood
thyrocervical artery
arises from the subclavian artery; supplies blood to the thyroid, the cervical region, the upper back, and shoulder
thyrohyoid
muscle that depresses the hyoid bone and elevates the larynx’s thyroid cartilage
thyroid cartilage
largest piece of cartilage that makes up the larynx and consists of two lamina
thyroid gland
large endocrine gland responsible for the synthesis of thyroid hormones
thyroid-stimulating hormone (TSH)
anterior pituitary hormone that triggers secretion of thyroid hormones by the thyroid gland (also called thyrotropin)
thyroxine
(also, tetraiodothyronine, T4) amino acid–derived thyroid hormone that is more abundant but less potent than T3 and often converted to T3 by target cells
tibia
shin bone; the large, weight-bearing bone located on the medial side of the leg
tibial collateral ligament
extrinsic ligament of knee joint that spans from the medial epicondyle of the femur to the medial tibia; resists hyperextension and rotation of extended knee
tibial nerve
systemic nerve of the posterior leg that begins as part of the sciatic nerve
tibial tuberosity
elevated area on the anterior surface of the proximal tibia
tibialis anterior
muscle located on the lateral surface of the tibia
tibialis posterior
muscle that plantar flexes and inverts the foot
Tidal volume (TV)
amount of air that normally enters the lungs during quiet breathing
tight junction
forms an impermeable barrier between cells
tissue
group of cells that are similar in form and perform related functions
tissue factor
protein thromboplastin, which initiates the extrinsic pathway when released in response to tissue damage
tissue membrane
thin layer or sheet of cells that covers the outside of the body, organs, and internal cavities
tissue typing
typing of MHC molecules between a recipient and donor for use in a potential transplantation procedure
tongue
accessory digestive organ of the mouth, the bulk of which is composed of skeletal muscle
tonsils
lymphoid nodules associated with the nasopharynx
total dead space
sum of the anatomical dead space and alveolar dead space
total lung capacity (TLC)
total amount of air that can be held in the lungs; sum of TV, ERV, IRV, and RV
total pressure
sum of all the partial pressures of a gaseous mixture
totipotent
embryonic cells that have the ability to differentiate into any type of cell and organ in the body
totipotent stem cell
embryonic stem cell that is capable of differentiating into any and all cells of the body; enabling the full development of an organism
trabeculae
(singular = trabecula) spikes or sections of the lattice-like matrix in spongy bone
trabeculae carneae
ridges of muscle covered by endocardium located in the ventricles
trachea
tube composed of cartilaginous rings and supporting tissue that connects the lung bronchi and the larynx; provides a route for air to enter and exit the lung
trachealis muscle
smooth muscle located in the fibroelastic membrane of the trachea
tract
bundle of axons in the central nervous system having the same function and point of origin
trait
variation of an expressed characteristic
transamination
transfer of an amine group from one molecule to another as a way to turn nitrogen waste into ammonia so that it can enter the urea cycle
transcription
process of producing an mRNA molecule that is complementary to a particular gene of DNA
transcription factors
one of the proteins that regulate the transcription of genes
transduction
process of changing an environmental stimulus into the electrochemical signals of the nervous system
transfer RNA (tRNA)
molecules of RNA that serve to bring amino acids to a growing polypeptide strand and properly place them into the sequence
transferrin
plasma protein that binds reversibly to iron and distributes it throughout the body
transient ischemic attack (TIA)
temporary loss of neurological function caused by a brief interruption in blood flow; also known as a mini-stroke
transitional epithelium
form of stratified epithelium found in the urinary tract, characterized by an apical layer of cells that change shape in response to the presence of urine
translation
process of producing a protein from the nucleotide sequence code of an mRNA transcript
transpulmonary pressure
pressure difference between the intrapleural and intra-alveolar pressures
transverse abdominis
deep layer of the abdomen that has fascicles arranged transversely around the abdomen
transverse colon
part of the colon between the ascending colon and the descending colon
transverse foramen
opening found only in the transverse processes of cervical vertebrae
transverse plane
two-dimensional, horizontal plane that divides the body or organ into superior and inferior portions
transverse process
paired bony processes that extends laterally from the vertebral arch of a vertebra
transverse sinuses
dural sinuses that drain blood from the occipital, the occipital–cerebellar space, sagittal, and straight sinuses into the sigmoid sinuses
transversospinales
muscles that originate at the transverse processes and insert at the spinous processes of the vertebrae
trapezium
from the lateral side, the first of the four distal carpal bones; articulates with the scaphoid proximally, the first and second metacarpals distally, and the trapezoid medially
trapezius
muscle that stabilizes the upper part of the back
trapezoid
from the lateral side, the second of the four distal carpal bones; articulates with the scaphoid proximally, the second metacarpal distally, the trapezium laterally, and the capitate medially
treppe
stepwise increase in contraction tension
tri
three
triad
the grouping of one T-tubule and two terminal cisternae
tricarboxylic acid cycle (TCA)
also called the Krebs cycle or the citric acid cycle; converts pyruvate into CO2 and high-energy FADH2, NADH, and ATP molecules
triceps brachii
three-headed muscle that extends the forearm
tricuspid valve
term used most often in clinical settings for the right atrioventricular valve
trigeminal ganglion
sensory ganglion that contributes sensory fibers to the trigeminal nerve
trigeminal nerve
fifth cranial nerve; responsible for cutaneous sensation of the face and contraction of the muscles of mastication
triglyceride
lipid compound composed of a glycerol molecule bonded with three fatty acid chains
triglycerides
lipids, or fats, consisting of three fatty acid chains attached to a glycerol backbone
trigone
area at the base of the bladder marked by the two ureters in the posterior–lateral aspect and the urethral orifice in the anterior aspect oriented like points on a triangle
triiodothyronine
(also, T3) amino acid–derived thyroid hormone that is less abundant but more potent than T4
trimester
division of the duration of a pregnancy into three 3-month terms
triplet
consecutive sequence of three nucleotides on a DNA molecule that, when transcribed into an mRNA codon, corresponds to a particular amino acid
triquetrum
from the lateral side, the third of the four proximal carpal bones; articulates with the lunate laterally, the hamate distally, and has a facet for the pisiform
trochlea of the eye
cartilaginous structure that acts like a pulley for the superior oblique muscle
trochlea of the humerus
pulley-shaped region located medially at the distal end of the humerus; articulates at the elbow with the trochlear notch of the ulna
trochlear nerve
fourth cranial nerve; responsible for contraction of one of the extraocular muscles
trochlear notch
large, C-shaped depression located on the anterior side of the proximal ulna; articulates at the elbow with the trochlea of the humerus
trophoblast
fluid-filled shell of squamous cells destined to become the chorionic villi, placenta, and associated fetal membranes
tropomyosin
regulatory protein that covers myosin-binding sites to prevent actin from binding to myosin
troponin
regulatory protein that binds to actin, tropomyosin, and calcium
true labor
regular contractions that immediately precede childbirth; they do not abate with hydration or rest, and they become more frequent and powerful with time
true ribs
vertebrosternal ribs 1–7 that attach via their costal cartilage directly to the sternum
true vocal cord
one of the pair of folded, white membranes that have a free inner edge that oscillates as air passes through to produce sound
truncus arteriosus
portion of the primitive heart that will eventually divide and give rise to the ascending aorta and pulmonary trunk
trunk
large vessel that gives rise to smaller vessels
trypsin
pancreatic enzyme that activates chymotrypsin and digests protein
trypsinogen
proenzyme form of trypsin
tubercle of the rib
small bump on the posterior side of a rib for articulation with the transverse process of a thoracic vertebra
tubuloglomerular feedback
feedback mechanism involving the JGA; macula densa cells monitor Na+ concentration in the terminal portion of the ascending loop of Henle and act to cause vasoconstriction or vasodilation of afferent and efferent arterioles to alter GFR
tunica externa
(also, tunica adventitia) outermost layer or tunic of a vessel (except capillaries)
tunica intima
(also, tunica interna) innermost lining or tunic of a vessel
tunica media
middle layer or tunic of a vessel (except capillaries)
twitch
single contraction produced by one action potential
tympanic membrane
ear drum
type I alveolar cell
squamous epithelial cells that are the major cell type in the alveolar wall; highly permeable to gases
type I hypersensitivity
immediate response mediated by mast cell degranulation caused by the crosslinking of the antigen-specific IgE molecules on the mast cell surface
type II alveolar cell
cuboidal epithelial cells that are the minor cell type in the alveolar wall; secrete pulmonary surfactant
type II hypersensitivity
cell damage caused by the binding of antibody and the activation of complement, usually against red blood cells
type III hypersensitivity
damage to tissues caused by the deposition of antibody-antigen (immune) complexes followed by the activation of complement

U

ulna
bone located on the medial side of the forearm
ulnar artery
formed at the bifurcation of the brachial artery; parallels the ulna; gives off smaller branches until it reaches the carpal region where it fuses with the radial artery to form the superficial and deep palmar arches; supplies blood to the lower arm and carpal region
ulnar collateral ligament
intrinsic ligament on the medial side of the elbow joint; spans from the medial epicondyle of the humerus to the medial ulna
ulnar nerve
systemic nerve of the arm located close to the ulna, a bone of the forearm
ulnar notch of the radius
shallow, smooth area located on the medial side of the distal radius; articulates with the head of the ulna at the distal radioulnar joint
ulnar tuberosity
roughened area located on the anterior, proximal ulna inferior to the coronoid process
ulnar vein
parallels the ulna and ulnar artery; arises from the palmar venous arches and leads to the brachial vein
ultrasonography
application of ultrasonic waves to visualize subcutaneous body structures such as tendons and organs
umami
taste submodality for sensitivity to the concentration of amino acids; also called the savory sense
umbilical arteries
pair of vessels that runs within the umbilical cord and carries fetal blood low in oxygen and high in waste to the placenta for exchange with maternal blood
umbilical cord
connection between the developing conceptus and the placenta; carries deoxygenated blood and wastes from the fetus and returns nutrients and oxygen from the mother
umbilical vein
single vessel that originates in the placenta and runs within the umbilical cord, carrying oxygen- and nutrient-rich blood to the fetal heart
uniaxial joint
type of diarthrosis; joint that allows for motion within only one plane (one axis)
unipennate
pennate muscle that has fascicles located on one side of the tendon
unipolar
shape of a neuron which has only one process that includes both the axon and dendrite
unipotent
describes the condition of being committed to a single specialized cell type
universal donor
individual with type O− blood
universal recipient
individual with type AB+ blood
upper esophageal sphincter
skeletal muscle sphincter that regulates food movement from the pharynx to the esophagus
upper motor neuron
first neuron in the motor command pathway with its cell body in the cerebral cortex that synapses on the lower motor neuron in the spinal cord
upregulation
increase in the number of hormone receptors, typically in response to chronically reduced levels of a hormone
urea cycle
process that converts potentially toxic nitrogen waste into urea that can be eliminated through the kidneys
urethra
transports urine from the bladder to the outside environment
urochrome
heme-derived pigment that imparts the typical yellow color of urine
urogenital triangle
anterior triangle of the perineum that includes the external genitals
uterine tubes
(also, fallopian tubes or oviducts) ducts that facilitate transport of an ovulated oocyte to the uterus
uterus
muscular hollow organ in which a fertilized egg develops into a fetus
utricle
structure of the inner ear responsible for transducing linear acceleration in the horizontal plane

V

vagina
tunnel-like organ that provides access to the uterus for the insertion of semen and from the uterus for the birth of a baby
vagus nerve
tenth cranial nerve; responsible for the autonomic control of organs in the thoracic and upper abdominal cavities
valence shell
outermost electron shell of an atom
Valsalva’s maneuver
voluntary contraction of the diaphragm and abdominal wall muscles and closing of the glottis, which increases intra-abdominal pressure and facilitates defecation
valve
in the cardiovascular system, a specialized structure located within the heart or vessels that ensures one-way flow of blood
variable region domain
part of a lymphocyte antigen receptor that varies considerably between different receptor types
varicosity
enlargement of neurons that release neurotransmitters into synaptic clefts
vasa recta
branches of the efferent arterioles that parallel the course of the loops of Henle and are continuous with the peritubular capillaries; with the glomerulus, form a portal system
vasa vasorum
small blood vessels located within the walls or tunics of larger vessels that supply nourishment to and remove wastes from the cells of the vessels
vascular shock
type of shock that occurs when arterioles lose their normal muscular tone and dilate dramatically
vascular shunt
continuation of the metarteriole and thoroughfare channel that allows blood to bypass the capillary beds to flow directly from the arterial to the venous circulation
vascular spasm
initial step in hemostasis, in which the smooth muscle in the walls of the ruptured or damaged blood vessel contracts
vascular tone
contractile state of smooth muscle in a blood vessel
vascular tubes
rudimentary blood vessels in a developing fetus
vascular tunic
middle layer of the eye primarily composed of connective tissue with a rich blood supply
vasoconstriction
constriction of the smooth muscle of a blood vessel, resulting in a decreased vascular diameter
vasodilation
relaxation of the smooth muscle in the wall of a blood vessel, resulting in an increased vascular diameter
vasomotion
irregular, pulsating flow of blood through capillaries and related structures
vasomotor nerves
preganglionic sympathetic fibers that cause the constriction of blood vessels in response to signals from the cardiovascular center
vastus intermedius
quadricep muscle that is between the vastus lateralis and vastus medialis and is deep to the rectus femoris
vastus lateralis
quadricep muscle on the lateral aspect of the thigh
vastus medialis
quadricep muscle on the medial aspect of the thigh
vein
blood vessel that conducts blood toward the heart
venous reserve
volume of blood contained within systemic veins in the integument, bone marrow, and liver that can be returned to the heart for circulation, if needed
ventilation
movement of air into and out of the lungs; consists of inspiration and expiration
ventral
describes the front or direction toward the front of the body; also referred to as anterior
ventral (anterior) nerve root
axons emerging from the anterior or lateral horns of the spinal cord
ventral posterior nucleus
nucleus in the thalamus that is the target of gustatory sensations and projects to the cerebral cortex
ventral respiratory group (VRG)
region of the medulla oblongata that stimulates the contraction of the accessory muscles involved in respiration to induce forced inspiration and expiration
ventral stream
connections between cortical areas from the occipital lobe to the temporal lobe that are responsible for identification of visual stimuli
ventricle of the brain
central cavity within the brain where CSF is produced and circulates
ventricle of the heart
one of the primary pumping chambers of the heart located in the lower portion of the heart; the left ventricle is the major pumping chamber on the lower left side of the heart that ejects blood into the systemic circuit via the aorta and receives blood from the left atrium; the right ventricle is the major pumping chamber on the lower right side of the heart that ejects blood into the pulmonary circuit via the pulmonary trunk and receives blood from the right atrium
ventricles
remnants of the hollow center of the neural tube that are spaces for cerebrospinal fluid to circulate through the brain
ventricular ejection phase
second phase of ventricular systole during which blood is pumped from the ventricle
venule
small vessel leading from the capillaries to veins
vermis
prominent ridge along the midline of the cerebellum that is referred to as the spinocerebellum
vernix caseosa
waxy, cheese-like substance that protects the delicate fetal skin until birth
vertebra
individual bone in the neck and back regions of the vertebral column
vertebral (spinal) canal
bony passageway within the vertebral column for the spinal cord that is formed by the series of individual vertebral foramina
vertebral arch
bony arch formed by the posterior portion of each vertebra that surrounds and protects the spinal cord
vertebral arteries
arteries that ascend along either side of the vertebral column through the transverse foramina of the cervical vertebrae and enter the cranium through the foramen magnum
vertebral artery
arises from the subclavian artery and passes through the vertebral foramen through the foramen magnum to the brain; joins with the internal carotid artery to form the arterial circle; supplies blood to the brain and spinal cord
vertebral column
entire sequence of bones that extend from the skull to the tailbone
vertebral foramen
opening associated with each vertebra defined by the vertebral arch that provides passage for the spinal cord
vertebral vein
arises from the base of the brain and the cervical region of the spinal cord; passes through the intervertebral foramina in the cervical vertebrae; drains smaller veins from the cranium, spinal cord, and vertebrae, and leads to the brachiocephalic vein; counterpart of the vertebral artery
vesicle
membrane-bound structure that contains materials within or outside of the cell
vestibular fold
part of the folded region of the glottis composed of mucous membrane; supports the epiglottis during swallowing
vestibular ganglion
location of neuronal cell bodies that transmit equilibrium information along the eighth cranial nerve
vestibular nuclei
targets of the vestibular component of the eighth cranial nerve
vestibule
in the ear, the portion of the inner ear responsible for the sense of equilibrium
vestibulo-ocular reflex (VOR)
reflex based on connections between the vestibular system and the cranial nerves of eye movements that ensures that images are stabilized on the retina as the head and body move
vestibulocerebellum
flocculonodular lobe of the cerebellum named for the vestibular input from the eighth cranial nerve
vestibulocochlear nerve
eighth cranial nerve; responsible for the sensations of hearing and balance
vestibulospinal tract
extrapyramidal connections between the vestibular nuclei in the brain stem and spinal cord that modulate movement and contribute to balance on the basis of the sense of equilibrium
villus
projection of the mucosa of the small intestine
visceral branches
branches of the descending aorta that supply blood to the viscera
visceral muscle
smooth muscle found in the walls of visceral organs
visceral pleura
innermost layer of the pleura that is superficial to the lungs and extends into the lung fissures
visceral reflex
reflex involving an internal organ as the effector, under the control of the autonomic nervous system
visceral sense
sense associated with the internal organs
vision
special sense of sight based on transduction of light stimuli
visual acuity
property of vision related to the sharpness of focus, which varies in relation to retinal position
Vital capacity (VC)
sum of TV, ERV, and IRV, which is all the volumes that participate in gas exchange
vitamin D
compound that aids absorption of calcium and phosphates in the intestine to improve bone health
vitamins
organic compounds required by the body to perform biochemical reactions like metabolism and bone, cell, and tissue growth
vitiligo
skin condition in which melanocytes in certain areas lose the ability to produce melanin, possibly due an autoimmune reaction that leads to loss of color in patches
vitreous humor
viscous fluid that fills the posterior chamber of the eye
voltage-gated channel
ion channel that opens because of a change in the charge distributed across the membrane where it is located
voltage-gated sodium channels
membrane proteins that open sodium channels in response to a sufficient voltage change, and initiate and transmit the action potential as Na+ enters through the channel
voluntary phase
initial phase of deglutition, in which the bolus moves from the mouth to the oropharynx
vomer bone
unpaired bone that forms the inferior and posterior portions of the nasal septum
vulva
external female genitalia

W

wave summation
addition of successive neural stimuli to produce greater contraction
Weber test
use of a tuning fork to test the laterality of hearing loss by placing it at several locations on the midline of the skull
Wernicke’s area
region at the posterior end of the lateral sulcus in which speech comprehension is localized
white blood cells (WBCs)
(also, leukocytes) one of the formed elements of blood that provides defense against disease agents and foreign materials
white matter
regions of the nervous system containing mostly myelinated axons, making the tissue appear white because of the high lipid content of myelin
white rami communicantes
(singular = ramus communicans) myelinated structures that provide a short connection from a sympathetic chain ganglion to the spinal nerve that contains the preganglionic sympathetic fiber
Wolffian duct
duct system present in the embryo that will eventually form the internal male reproductive structures
working memory
function of the prefrontal cortex to maintain a representation of information that is not in the immediate environment
wound contraction
process whereby the borders of a wound are physically drawn together

X

X-linked
pattern of inheritance in which an allele is carried on the X chromosome of the 23rd pair
X-linked dominant
pattern of dominant inheritance that corresponds to a gene on the X chromosome of the 23rd pair
X-linked recessive
pattern of recessive inheritance that corresponds to a gene on the X chromosome of the 23rd pair
x-ray
form of high energy electromagnetic radiation with a short wavelength capable of penetrating solids and ionizing gases; used in medicine as a diagnostic aid to visualize body structures such as bones
xiphoid process
small process that forms the inferior tip of the sternum

Y

yellow bone marrow
connective tissue in the interior cavity of a bone where fat is stored
yolk sac
membrane associated with primitive circulation to the developing embryo; source of the first blood cells and germ cells and contributes to the umbilical cord structure

Z

zona fasciculata
intermediate region of the adrenal cortex that produce hormones called glucocorticoids
zona glomerulosa
most superficial region of the adrenal cortex, which produces the hormones collectively referred to as mineralocorticoids
zona pellucida
thick, gel-like glycoprotein membrane that coats the oocyte and must be penetrated by sperm before fertilization can occur
zona reticularis
deepest region of the adrenal cortex, which produces the steroid sex hormones called androgens
zone of calcified matrix
region of the epiphyseal plate closest to the diaphyseal end; functions to connect the epiphyseal plate to the diaphysis
zone of maturation and hypertrophy
region of the epiphyseal plate where chondrocytes from the proliferative zone grow and mature and contribute to the longitudinal growth of the epiphyseal plate
zonule fibers
fibrous connections between the ciliary body and the lens
zygapophysial joints
facet joints; plane joints between the superior and inferior articular processes of adjacent vertebrae that provide for only limited motions between the vertebrae
zygomatic arch
elongated, free-standing arch on the lateral skull, formed anteriorly by the temporal process of the zygomatic bone and posteriorly by the zygomatic process of the temporal bone
zygomatic bone
cheekbone; paired bones that contribute to the lateral orbit and anterior zygomatic arch
zygomatic process of the temporal bone
extension from the temporal bone that forms the posterior portion of the zygomatic arch
zygote
fertilized egg; a diploid cell resulting from the fertilization of haploid gametes from the male and female lines

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Anatomy & Physiology 2e Copyright © 2025 by Lindsay M. Biga, Staci Bronson, Sierra Dawson, Amy Harwell, Robin Hopkins, Joel Kaufmann, Mike LeMaster, Philip Matern, Katie Morrison-Graham, Kristen Oja, Devon Quick, Jon Runyeon, and OpenStax is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License, except where otherwise noted.